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Items: 1 to 20 of 189

1.

Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau₄₅₋₂₃₀ transgenic mice.

Lang AE, Riherd Methner DN, Ferreira A.

Neuroscience. 2014 Sep 5;275:322-39. doi: 10.1016/j.neuroscience.2014.06.017. Epub 2014 Jun 18.

2.

Neurofibrillary tangle formation by introducing wild-type human tau into APP transgenic mice.

Umeda T, Maekawa S, Kimura T, Takashima A, Tomiyama T, Mori H.

Acta Neuropathol. 2014 May;127(5):685-98. doi: 10.1007/s00401-014-1259-1. Epub 2014 Feb 15.

PMID:
24531886
3.

Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice.

Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N.

Neurobiol Dis. 2011 Jun;42(3):404-14. doi: 10.1016/j.nbd.2011.02.002. Epub 2011 Feb 13.

PMID:
21324362
4.

Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease.

Saul A, Sprenger F, Bayer TA, Wirths O.

Neurobiol Aging. 2013 Nov;34(11):2564-73. doi: 10.1016/j.neurobiolaging.2013.05.003. Epub 2013 Jun 5.

PMID:
23747045
5.

Hippocampal tauopathy in tau transgenic mice coincides with impaired hippocampus-dependent learning and memory, and attenuated late-phase long-term depression of synaptic transmission.

Van der Jeugd A, Ahmed T, Burnouf S, Belarbi K, Hamdame M, Grosjean ME, Humez S, Balschun D, Blum D, Buée L, D'Hooge R.

Neurobiol Learn Mem. 2011 Mar;95(3):296-304. doi: 10.1016/j.nlm.2010.12.005. Epub 2010 Dec 16.

PMID:
21167950
6.

Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology.

Polydoro M, Acker CM, Duff K, Castillo PE, Davies P.

J Neurosci. 2009 Aug 26;29(34):10741-9. doi: 10.1523/JNEUROSCI.1065-09.2009.

7.
8.

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau.

Van der Jeugd A, Hochgräfe K, Ahmed T, Decker JM, Sydow A, Hofmann A, Wu D, Messing L, Balschun D, D'Hooge R, Mandelkow EM.

Acta Neuropathol. 2012 Jun;123(6):787-805. doi: 10.1007/s00401-012-0987-3. Epub 2012 Apr 25.

9.

Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.

Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, Decarr LB, Yang L, Liu V, Fessler C, Protassio J, Riff T, Turner H, Janus CG, Sankaranarayanan S, Polson C, Meredith JE, Gray G, Hanna A, Olson RE, Kim SH, Vite GD, Lee FY, Albright CF.

J Neurosci. 2012 May 23;32(21):7137-45. doi: 10.1523/JNEUROSCI.0188-12.2012.

10.

Tau-induced defects in synaptic plasticity, learning, and memory are reversible in transgenic mice after switching off the toxic Tau mutant.

Sydow A, Van der Jeugd A, Zheng F, Ahmed T, Balschun D, Petrova O, Drexler D, Zhou L, Rune G, Mandelkow E, D'Hooge R, Alzheimer C, Mandelkow EM.

J Neurosci. 2011 Feb 16;31(7):2511-25. doi: 10.1523/JNEUROSCI.5245-10.2011.

11.

A NH2 tau fragment targets neuronal mitochondria at AD synapses: possible implications for neurodegeneration.

Amadoro G, Corsetti V, Stringaro A, Colone M, D'Aguanno S, Meli G, Ciotti M, Sancesario G, Cattaneo A, Bussani R, Mercanti D, Calissano P.

J Alzheimers Dis. 2010;21(2):445-70. doi: 10.3233/JAD-2010-100120.

PMID:
20571215
12.

A novel triple repeat mutant tau transgenic model that mimics aspects of pick's disease and fronto-temporal tauopathies.

Rockenstein E, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Bisquert A, Trejo-Morales M, Spencer B, Masliah E.

PLoS One. 2015 Mar 24;10(3):e0121570. doi: 10.1371/journal.pone.0121570. eCollection 2015.

13.

Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies.

Ferreira A, Bigio EH.

Mol Med. 2011;17(7-8):676-85. doi: 10.2119/molmed.2010.00220. Epub 2011 Mar 21.

14.

Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau.

Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW.

J Neurocytol. 2003 Nov;32(9):1091-105.

PMID:
15044841
15.

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy.

Kraemer BC, Zhang B, Leverenz JB, Thomas JH, Trojanowski JQ, Schellenberg GD.

Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9980-5. Epub 2003 Jul 18.

16.

Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice.

Britschgi M, Takeda-Uchimura Y, Rockenstein E, Johns H, Masliah E, Wyss-Coray T.

J Neuroinflammation. 2012 Sep 18;9:220. doi: 10.1186/1742-2094-9-220.

17.

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice.

Stancu IC, Vasconcelos B, Ris L, Wang P, Villers A, Peeraer E, Buist A, Terwel D, Baatsen P, Oyelami T, Pierrot N, Casteels C, Bormans G, Kienlen-Campard P, Octave JN, Moechars D, Dewachter I.

Acta Neuropathol. 2015 Jun;129(6):875-94. doi: 10.1007/s00401-015-1413-4. Epub 2015 Apr 11.

18.

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.

Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E, Segal M, Ginzburg I, Abramsky O.

Exp Neurol. 2008 Jul;212(1):71-84. doi: 10.1016/j.expneurol.2008.03.007. Epub 2008 Mar 21.

PMID:
18490011
19.

Propagation of tau pathology in a model of early Alzheimer's disease.

de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT.

Neuron. 2012 Feb 23;73(4):685-97. doi: 10.1016/j.neuron.2011.11.033. Erratum in: Neuron. 2012 Oct 18;76(2):461.

20.

Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.

Ma QL, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M, Kiosea NC, Nazari S, Chen PP, Nothias F, Chan P, Teng E, Frautschy SA, Cole GM.

J Neurosci. 2014 May 21;34(21):7124-36. doi: 10.1523/JNEUROSCI.3439-13.2014.

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