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Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.

Lebrun-Julien F, Bachmann L, Norrmén C, Trötzmüller M, Köfeler H, Rüegg MA, Hall MN, Suter U.

J Neurosci. 2014 Jun 18;34(25):8432-48. doi: 10.1523/JNEUROSCI.1105-14.2014.


Conditional ablation of raptor or rictor has differential impact on oligodendrocyte differentiation and CNS myelination.

Bercury KK, Dai J, Sachs HH, Ahrendsen JT, Wood TL, Macklin WB.

J Neurosci. 2014 Mar 26;34(13):4466-80. doi: 10.1523/JNEUROSCI.4314-13.2014.


Loss of Tuberous Sclerosis Complex1 in Adult Oligodendrocyte Progenitor Cells Enhances Axon Remyelination and Increases Myelin Thickness after a Focal Demyelination.

McLane LE, Bourne JN, Evangelou AV, Khandker L, Macklin WB, Wood TL.

J Neurosci. 2017 Aug 2;37(31):7534-7546. doi: 10.1523/JNEUROSCI.3454-16.2017. Epub 2017 Jul 10.


Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2-MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner.

Furusho M, Ishii A, Bansal R.

J Neurosci. 2017 Mar 15;37(11):2931-2946. doi: 10.1523/JNEUROSCI.3316-16.2017. Epub 2017 Feb 13.


Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.

Narayanan SP, Flores AI, Wang F, Macklin WB.

J Neurosci. 2009 May 27;29(21):6860-70. doi: 10.1523/JNEUROSCI.0232-09.2009.


Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination.

Wahl SE, McLane LE, Bercury KK, Macklin WB, Wood TL.

J Neurosci. 2014 Mar 26;34(13):4453-65. doi: 10.1523/JNEUROSCI.4311-13.2014.


Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain.

Zou Y, Jiang W, Wang J, Li Z, Zhang J, Bu J, Zou J, Zhou L, Yu S, Cui Y, Yang W, Luo L, Lu QR, Liu Y, Chen M, Worley PF, Xiao B.

J Neurosci. 2014 Nov 19;34(47):15764-78. doi: 10.1523/JNEUROSCI.2267-14.2014.


mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.

Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U.

Cell Rep. 2014 Oct 23;9(2):646-60. doi: 10.1016/j.celrep.2014.09.001. Epub 2014 Oct 9.


Imbalanced mechanistic target of rapamycin C1 and C2 activity in the cerebellum of Angelman syndrome mice impairs motor function.

Sun J, Liu Y, Moreno S, Baudry M, Bi X.

J Neurosci. 2015 Mar 18;35(11):4706-18. doi: 10.1523/JNEUROSCI.4276-14.2015.


Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiation.

Tyler WA, Gangoli N, Gokina P, Kim HA, Covey M, Levison SW, Wood TL.

J Neurosci. 2009 May 13;29(19):6367-78. doi: 10.1523/JNEUROSCI.0234-09.2009.


Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complex.

Carson RP, Fu C, Winzenburger P, Ess KC.

Hum Mol Genet. 2013 Jan 1;22(1):140-52. doi: 10.1093/hmg/dds414. Epub 2012 Oct 9.


Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2.

Padovani-Claudio DA, Liu L, Ransohoff RM, Miller RH.

Glia. 2006 Oct;54(5):471-83.


Predominance of mTORC1 over mTORC2 in the regulation of proliferation of ovarian cancer cells: therapeutic implications.

Montero JC, Chen X, Ocaña A, Pandiella A.

Mol Cancer Ther. 2012 Jun;11(6):1342-52. doi: 10.1158/1535-7163.MCT-11-0723. Epub 2012 Apr 10.


A unique role for Fyn in CNS myelination.

Sperber BR, Boyle-Walsh EA, Engleka MJ, Gadue P, Peterson AC, Stein PL, Scherer SS, McMorris FA.

J Neurosci. 2001 Mar 15;21(6):2039-47.


Fisetin regulates obesity by targeting mTORC1 signaling.

Jung CH, Kim H, Ahn J, Jeon TI, Lee DH, Ha TY.

J Nutr Biochem. 2013 Aug;24(8):1547-54. doi: 10.1016/j.jnutbio.2013.01.003. Epub 2013 Mar 18.


LINGO-1 negatively regulates myelination by oligodendrocytes.

Mi S, Miller RH, Lee X, Scott ML, Shulag-Morskaya S, Shao Z, Chang J, Thill G, Levesque M, Zhang M, Hession C, Sah D, Trapp B, He Z, Jung V, McCoy JM, Pepinsky RB.

Nat Neurosci. 2005 Jun;8(6):745-51. Epub 2005 May 15.


Distribution and association of mTOR with its cofactors, raptor and rictor, in cumulus cells and oocytes during meiotic maturation in mice.

Kogasaka Y, Hoshino Y, Hiradate Y, Tanemura K, Sato E.

Mol Reprod Dev. 2013 Apr;80(4):334-48. doi: 10.1002/mrd.22166. Epub 2013 Mar 26.


mTORC1 and mTORC2 have largely distinct functions in Purkinje cells.

Angliker N, Burri M, Zaichuk M, Fritschy JM, Rüegg MA.

Eur J Neurosci. 2015 Oct;42(8):2595-612. doi: 10.1111/ejn.13051. Epub 2015 Sep 18.


Fetal brain mTOR signaling activation in tuberous sclerosis complex.

Tsai V, Parker WE, Orlova KA, Baybis M, Chi AW, Berg BD, Birnbaum JF, Estevez J, Okochi K, Sarnat HB, Flores-Sarnat L, Aronica E, Crino PB.

Cereb Cortex. 2014 Feb;24(2):315-27. doi: 10.1093/cercor/bhs310. Epub 2012 Oct 18.

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