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Items: 1 to 20 of 100

1.

Selective targeting of TGF-β activation to treat fibroinflammatory airway disease.

Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL.

Sci Transl Med. 2014 Jun 18;6(241):241ra79. doi: 10.1126/scitranslmed.3008074.

2.

Transforming Growth Factor-β and Interleukin-1β Signaling Pathways Converge on the Chemokine CCL20 Promoter.

Brand OJ, Somanath S, Moermans C, Yanagisawa H, Hashimoto M, Cambier S, Markovics J, Bondesson AJ, Hill A, Jablons D, Wolters P, Lou J, Marks JD, Baron JL, Nishimura SL.

J Biol Chem. 2015 Jun 5;290(23):14717-28. doi: 10.1074/jbc.M114.630368. Epub 2015 Apr 27.

3.

Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue.

Fjellbirkeland L, Cambier S, Broaddus VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL.

Am J Pathol. 2003 Aug;163(2):533-42.

4.

Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture.

Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL.

J Biol Chem. 2011 Oct 21;286(42):36864-74. doi: 10.1074/jbc.M111.276790. Epub 2011 Aug 30.

5.

Mesangial cell integrin αvβ8 provides glomerular endothelial cell cytoprotection by sequestering TGF-β and regulating PECAM-1.

Khan S, Lakhe-Reddy S, McCarty JH, Sorenson CM, Sheibani N, Reichardt LF, Kim JH, Wang B, Sedor JR, Schelling JR.

Am J Pathol. 2011 Feb;178(2):609-20. doi: 10.1016/j.ajpath.2010.10.031.

6.

Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin αvβ8-mediated activation of TGF-β.

Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL.

J Clin Invest. 2011 Jul;121(7):2863-75. doi: 10.1172/JCI45589. Epub 2011 Jun 6.

7.

TGF-β activation and lung fibrosis.

Tatler AL, Jenkins G.

Proc Am Thorac Soc. 2012 Jul;9(3):130-6. doi: 10.1513/pats.201201-003AW.

PMID:
22802287
8.

The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan.

Tsui P, Higazi DR, Wu Y, Dunmore R, Solier E, Kasali T, Bond NJ, Huntington C, Carruthers A, Hood J, Borrok MJ, Barnes A, Rickert K, Phipps S, Shirinian L, Zhu J, Bowen MA, Dall'Acqua W, Murray LA.

MAbs. 2017 Jan;9(1):104-113. doi: 10.1080/19420862.2016.1255390. Epub 2016 Nov 11.

PMID:
27834568
9.

TGF-β-Dependent Dendritic Cell Chemokinesis in Murine Models of Airway Disease.

Hashimoto M, Yanagisawa H, Minagawa S, Sen D, Ma R, Murray LA, Tsui P, Lou J, Marks JD, Baron JL, Krummel MF, Nishimura SL.

J Immunol. 2015 Aug 1;195(3):1182-90. doi: 10.4049/jimmunol.1500348. Epub 2015 Jun 24.

10.

Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma.

Tatler AL, John AE, Jolly L, Habgood A, Porte J, Brightling C, Knox AJ, Pang L, Sheppard D, Huang X, Jenkins G.

J Immunol. 2011 Dec 1;187(11):6094-107. doi: 10.4049/jimmunol.1003507. Epub 2011 Oct 24.

11.

Intestinal dendritic cells specialize to activate transforming growth factor-β and induce Foxp3+ regulatory T cells via integrin αvβ8.

Worthington JJ, Czajkowska BI, Melton AC, Travis MA.

Gastroenterology. 2011 Nov;141(5):1802-12. doi: 10.1053/j.gastro.2011.06.057. Epub 2011 Jun 30.

12.

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.

Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L726-35. doi: 10.1152/ajplung.00357.2013. Epub 2014 Feb 7.

13.

Inhibition of integrin alpha(v)beta6, an activator of latent transforming growth factor-beta, prevents radiation-induced lung fibrosis.

Puthawala K, Hadjiangelis N, Jacoby SC, Bayongan E, Zhao Z, Yang Z, Devitt ML, Horan GS, Weinreb PH, Lukashev ME, Violette SM, Grant KS, Colarossi C, Formenti SC, Munger JS.

Am J Respir Crit Care Med. 2008 Jan 1;177(1):82-90. Epub 2007 Oct 4.

14.

Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model.

Jaffer OA, Carter AB, Sanders PN, Dibbern ME, Winters CJ, Murthy S, Ryan AJ, Rokita AG, Prasad AM, Zabner J, Kline JN, Grumbach IM, Anderson ME.

Am J Respir Cell Mol Biol. 2015 Jan;52(1):106-15. doi: 10.1165/rcmb.2013-0519OC.

15.

Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure.

Neurohr C, Nishimura SL, Sheppard D.

Am J Respir Cell Mol Biol. 2006 Aug;35(2):252-9. Epub 2006 Mar 30.

16.

Interaction of tgf-beta with immune cells in airway disease.

Moore B, Murphy RF, Agrawal DK.

Curr Mol Med. 2008 Aug;8(5):427-36. Review.

PMID:
18691070
17.

The footprint of TGF-β in airway remodeling of the mustard lung.

Shahriary A, Seyedzadeh MH, Ahmadi A, Salimian J.

Inhal Toxicol. 2015;27(14):745-53. doi: 10.3109/08958378.2015.1116645. Epub 2015 Nov 26. Review.

PMID:
26606948
18.

Epithelial-mesenchymal interactions in fibrosis and repair. Transforming growth factor-β activation by epithelial cells and fibroblasts.

Sheppard D.

Ann Am Thorac Soc. 2015 Mar;12 Suppl 1:S21-3. doi: 10.1513/AnnalsATS.201406-245MG. Review.

19.

Molecular Basis of the Ligand Binding Specificity of αvβ8 Integrin.

Ozawa A, Sato Y, Imabayashi T, Uemura T, Takagi J, Sekiguchi K.

J Biol Chem. 2016 May 27;291(22):11551-65. doi: 10.1074/jbc.M116.719138. Epub 2016 Mar 31.

PMID:
27033701
20.

Mesangial cell αvβ8-integrin regulates glomerular capillary integrity and repair.

Lakhe-Reddy S, Li V, Arnold TD, Khan S, Schelling JR.

Am J Physiol Renal Physiol. 2014 Jun 15;306(12):F1400-9. doi: 10.1152/ajprenal.00624.2013. Epub 2014 Apr 16.

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