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RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex.

Shamanna RA, Singh DK, Lu H, Mirey G, Keijzers G, Salles B, Croteau DL, Bohr VA.

Carcinogenesis. 2014 Nov;35(11):2415-24. doi: 10.1093/carcin/bgu137. Epub 2014 Jun 18.


Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.

Parvathaneni S, Stortchevoi A, Sommers JA, Brosh RM Jr, Sharma S.

PLoS One. 2013 May 1;8(5):e62481. doi: 10.1371/journal.pone.0062481. Print 2013.


Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.

Choi YJ, Li H, Son MY, Wang XH, Fornsaglio JL, Sobol RW, Lee M, Vijg J, Imholz S, Dollé ME, van Steeg H, Reiling E, Hasty P.

PLoS One. 2014 Jan 23;9(1):e86358. doi: 10.1371/journal.pone.0086358. eCollection 2014.


KARP-1 works as a heterodimer with Ku70, but the function of KARP-1 cannot perfectly replace that of Ku80 in DSB repair.

Koike M, Yutoku Y, Koike A.

Exp Cell Res. 2011 Oct 1;317(16):2267-75. doi: 10.1016/j.yexcr.2011.06.015. Epub 2011 Jul 2.


RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance.

Ghosh AK, Rossi ML, Singh DK, Dunn C, Ramamoorthy M, Croteau DL, Liu Y, Bohr VA.

J Biol Chem. 2012 Jan 2;287(1):196-209. doi: 10.1074/jbc.M111.295063. Epub 2011 Oct 28.


A novel small molecule inhibitor of the DNA repair protein Ku70/80.

Weterings E, Gallegos AC, Dominick LN, Cooke LS, Bartels TN, Vagner J, Matsunaga TO, Mahadevan D.

DNA Repair (Amst). 2016 Jul;43:98-106. doi: 10.1016/j.dnarep.2016.03.014. Epub 2016 Apr 7.


PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways.

Beck C, Boehler C, Guirouilh Barbat J, Bonnet ME, Illuzzi G, Ronde P, Gauthier LR, Magroun N, Rajendran A, Lopez BS, Scully R, Boussin FD, Schreiber V, Dantzer F.

Nucleic Acids Res. 2014 May;42(9):5616-32. doi: 10.1093/nar/gku174. Epub 2014 Mar 5.


Biochemical evidence for Ku-independent backup pathways of NHEJ.

Wang H, Perrault AR, Takeda Y, Qin W, Wang H, Iliakis G.

Nucleic Acids Res. 2003 Sep 15;31(18):5377-88.


The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends.

Weterings E, Verkaik NS, Keijzers G, Florea BI, Wang SY, Ortega LG, Uematsu N, Chen DJ, van Gent DC.

Mol Cell Biol. 2009 Mar;29(5):1134-42. doi: 10.1128/MCB.00971-08. Epub 2008 Dec 22.


Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase.

Lee KJ, Saha J, Sun J, Fattah KR, Wang SC, Jakob B, Chi L, Wang SY, Taucher-Scholz G, Davis AJ, Chen DJ.

Nucleic Acids Res. 2016 Feb 29;44(4):1732-45. doi: 10.1093/nar/gkv1499. Epub 2015 Dec 27.


DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.

Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP.

DNA Repair (Amst). 2005 Aug 15;4(9):1006-18.


The involvement of human RECQL4 in DNA double-strand break repair.

Singh DK, Karmakar P, Aamann M, Schurman SH, May A, Croteau DL, Burks L, Plon SE, Bohr VA.

Aging Cell. 2010 Jun;9(3):358-71. doi: 10.1111/j.1474-9726.2010.00562.x. Epub 2010 Mar 6.


RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.

Yin J, Kwon YT, Varshavsky A, Wang W.

Hum Mol Genet. 2004 Oct 15;13(20):2421-30. Epub 2004 Aug 18.


Two-Stage Synapsis of DNA Ends during Non-homologous End Joining.

Graham TG, Walter JC, Loparo JJ.

Mol Cell. 2016 Mar 17;61(6):850-8. doi: 10.1016/j.molcel.2016.02.010.


The mutagenic potential of non-homologous end joining in the absence of the NHEJ core factors Ku70/80, DNA-PKcs and XRCC4-LigIV.

Kuhfittig-Kulle S, Feldmann E, Odersky A, Kuliczkowska A, Goedecke W, Eggert A, Pfeiffer P.

Mutagenesis. 2007 May;22(3):217-33. Epub 2007 Mar 7.


The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.

Shamanna RA, Hoque M, Lewis-Antes A, Azzam EI, Lagunoff D, Pe'ery T, Mathews MB.

Mol Cell Biol. 2011 Dec;31(23):4832-43. doi: 10.1128/MCB.05849-11. Epub 2011 Oct 3.


An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation.

Postow L, Funabiki H.

Cell Cycle. 2013 Feb 15;12(4):587-95. doi: 10.4161/cc.23408. Epub 2013 Jan 16.


Suppression of DNA-PKcs and Ku80 individually and in combination: Different effects of radiobiology in HeLa cells.

Zhuang L, Cao Y, Xiong H, Gao Q, Cao Z, Liu F, Qiu H, Yu S, Huang X.

Int J Oncol. 2011 Aug;39(2):443-51. doi: 10.3892/ijo.2011.1041. Epub 2011 May 13.


APLF promotes the assembly and activity of non-homologous end joining protein complexes.

Grundy GJ, Rulten SL, Zeng Z, Arribas-Bosacoma R, Iles N, Manley K, Oliver A, Caldecott KW.

EMBO J. 2013 Jan 9;32(1):112-25. doi: 10.1038/emboj.2012.304. Epub 2012 Nov 23.


Modeling damage complexity-dependent non-homologous end-joining repair pathway.

Li Y, Reynolds P, O'Neill P, Cucinotta FA.

PLoS One. 2014 Feb 10;9(2):e85816. doi: 10.1371/journal.pone.0085816. eCollection 2014.

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