Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 110


The CD2 isoform of protocadherin-15 is an essential component of the tip-link complex in mature auditory hair cells.

Pepermans E, Michel V, Goodyear R, Bonnet C, Abdi S, Dupont T, Gherbi S, Holder M, Makrelouf M, Hardelin JP, Marlin S, Zenati A, Richardson G, Avan P, Bahloul A, Petit C.

EMBO Mol Med. 2014 Jul;6(7):984-92. doi: 10.15252/emmm.201403976.


Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain.

Webb SW, Grillet N, Andrade LR, Xiong W, Swarthout L, Della Santina CC, Kachar B, Müller U.

Development. 2011 Apr;138(8):1607-17. doi: 10.1242/dev.060061.


Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.

Kazmierczak P, Sakaguchi H, Tokita J, Wilson-Kubalek EM, Milligan RA, Müller U, Kachar B.

Nature. 2007 Sep 6;449(7158):87-91.


Development and regeneration of sensory transduction in auditory hair cells requires functional interaction between cadherin-23 and protocadherin-15.

Lelli A, Kazmierczak P, Kawashima Y, Müller U, Holt JR.

J Neurosci. 2010 Aug 25;30(34):11259-69. doi: 10.1523/JNEUROSCI.1949-10.2010.


The tip-link molecular complex of the auditory mechano-electrical transduction machinery.

Pepermans E, Petit C.

Hear Res. 2015 Dec;330(Pt A):10-7. doi: 10.1016/j.heares.2015.05.005. Epub 2015 Jun 3. Review.


Mutations in protocadherin 15 and cadherin 23 affect tip links and mechanotransduction in mammalian sensory hair cells.

Alagramam KN, Goodyear RJ, Geng R, Furness DN, van Aken AF, Marcotti W, Kros CJ, Richardson GP.

PLoS One. 2011 Apr 21;6(4):e19183. doi: 10.1371/journal.pone.0019183.


Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.

Geng R, Sotomayor M, Kinder KJ, Gopal SR, Gerka-Stuyt J, Chen DH, Hardisty-Hughes RE, Ball G, Parker A, Gaudet R, Furness D, Brown SD, Corey DP, Alagramam KN.

J Neurosci. 2013 Mar 6;33(10):4395-404. doi: 10.1523/JNEUROSCI.4514-12.2013.


Molecular remodeling of tip links underlies mechanosensory regeneration in auditory hair cells.

Indzhykulian AA, Stepanyan R, Nelina A, Spinelli KJ, Ahmed ZM, Belyantseva IA, Friedman TB, Barr-Gillespie PG, Frolenkov GI.

PLoS Biol. 2013;11(6):e1001583. doi: 10.1371/journal.pbio.1001583. Epub 2013 Jun 11.


Cadherins and mechanotransduction by hair cells.

Müller U.

Curr Opin Cell Biol. 2008 Oct;20(5):557-66. doi: 10.1016/ Epub 2008 Jul 30. Review.


Functional Analysis of the Transmembrane and Cytoplasmic Domains of Pcdh15a in Zebrafish Hair Cells.

Maeda R, Pacentine IV, Erickson T, Nicolson T.

J Neurosci. 2017 Mar 22;37(12):3231-3245. doi: 10.1523/JNEUROSCI.2216-16.2017. Epub 2017 Feb 20.


The tip-link antigen, a protein associated with the transduction complex of sensory hair cells, is protocadherin-15.

Ahmed ZM, Goodyear R, Riazuddin S, Lagziel A, Legan PK, Behra M, Burgess SM, Lilley KS, Wilcox ER, Riazuddin S, Griffith AJ, Frolenkov GI, Belyantseva IA, Richardson GP, Friedman TB.

J Neurosci. 2006 Jun 28;26(26):7022-34.


Tip links in hair cells: molecular composition and role in hearing loss.

Sakaguchi H, Tokita J, Müller U, Kachar B.

Curr Opin Otolaryngol Head Neck Surg. 2009 Oct;17(5):388-93. doi: 10.1097/MOO.0b013e3283303472. Review.


Tip-link protein protocadherin 15 interacts with transmembrane channel-like proteins TMC1 and TMC2.

Maeda R, Kindt KS, Mo W, Morgan CP, Erickson T, Zhao H, Clemens-Grisham R, Barr-Gillespie PG, Nicolson T.

Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12907-12. doi: 10.1073/pnas.1402152111. Epub 2014 Aug 11.


Hair cells, plasma membrane Ca²⁺ ATPase and deafness.

Giacomello M, De Mario A, Primerano S, Brini M, Carafoli E.

Int J Biochem Cell Biol. 2012 May;44(5):679-83. doi: 10.1016/j.biocel.2012.02.006. Epub 2012 Feb 13. Review.


Spatiotemporal changes in the distribution of LHFPL5 in mice cochlear hair bundles during development and in the absence of PCDH15.

Mahendrasingam S, Fettiplace R, Alagramam KN, Cross E, Furness DN.

PLoS One. 2017 Oct 25;12(10):e0185285. doi: 10.1371/journal.pone.0185285. eCollection 2017.


Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts.

Haywood-Watson RJ 2nd, Ahmed ZM, Kjellstrom S, Bush RA, Takada Y, Hampton LL, Battey JF, Sieving PA, Friedman TB.

Invest Ophthalmol Vis Sci. 2006 Jul;47(7):3074-84.


Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia.

Caberlotto E, Michel V, Foucher I, Bahloul A, Goodyear RJ, Pepermans E, Michalski N, Perfettini I, Alegria-Prévot O, Chardenoux S, Do Cruzeiro M, Hardelin JP, Richardson GP, Avan P, Weil D, Petit C.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5825-30. doi: 10.1073/pnas.1017114108. Epub 2011 Mar 21.


Characterization of a new allele of Ames waltzer generated by ENU mutagenesis.

Washington JL 3rd, Pitts D, Wright CG, Erway LC, Davis RR, Alagramam K.

Hear Res. 2005 Apr;202(1-2):161-9.


Transduction without tip links in cochlear hair cells is mediated by ion channels with permeation properties distinct from those of the mechano-electrical transducer channel.

Marcotti W, Corns LF, Desmonds T, Kirkwood NK, Richardson GP, Kros CJ.

J Neurosci. 2014 Apr 16;34(16):5505-14. doi: 10.1523/JNEUROSCI.4086-13.2014.


TMIE is an essential component of the mechanotransduction machinery of cochlear hair cells.

Zhao B, Wu Z, Grillet N, Yan L, Xiong W, Harkins-Perry S, Müller U.

Neuron. 2014 Dec 3;84(5):954-67. doi: 10.1016/j.neuron.2014.10.041. Epub 2014 Nov 20.

Supplemental Content

Support Center