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Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice.

Zhu X, Park J, Golinski J, Qiu J, Khuman J, Lee CC, Lo EH, Degterev A, Whalen MJ.

J Cereb Blood Flow Metab. 2014 Sep;34(9):1531-9. doi: 10.1038/jcbfm.2014.113. Epub 2014 Jun 18.


Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice.

Park J, Zhang J, Qiu J, Zhu X, Degterev A, Lo EH, Whalen MJ.

J Cereb Blood Flow Metab. 2012 Feb;32(2):330-40. doi: 10.1038/jcbfm.2011.131. Epub 2011 Sep 21.


Akt and mTOR mediate programmed necrosis in neurons.

Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ.

Cell Death Dis. 2014 Feb 27;5:e1084. doi: 10.1038/cddis.2014.69.


Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice.

Khuman J, Meehan WP 3rd, Zhu X, Qiu J, Hoffmann U, Zhang J, Giovannone E, Lo EH, Whalen MJ.

J Cereb Blood Flow Metab. 2011 Feb;31(2):778-89. doi: 10.1038/jcbfm.2010.172. Epub 2010 Oct 13.


The effects of mTOR-Akt interactions on anti-apoptotic signaling in vascular endothelial cells.

Dormond O, Madsen JC, Briscoe DM.

J Biol Chem. 2007 Aug 10;282(32):23679-86. Epub 2007 Jun 6.


PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways.

Xiong X, Xie R, Zhang H, Gu L, Xie W, Cheng M, Jian Z, Kovacina K, Zhao H.

Neurobiol Dis. 2014 Jun;66:43-52. doi: 10.1016/j.nbd.2014.02.006. Epub 2014 Feb 27.


Phosphorylation of mTOR and S6RP predicts the efficacy of everolimus in patients with metastatic renal cell carcinoma.

Li S, Kong Y, Si L, Chi Z, Cui C, Sheng X, Guo J.

BMC Cancer. 2014 May 28;14:376. doi: 10.1186/1471-2407-14-376.


Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells.

Zhong LM, Zong Y, Sun L, Guo JZ, Zhang W, He Y, Song R, Wang WM, Xiao CJ, Lu D.

PLoS One. 2012;7(2):e32195. doi: 10.1371/journal.pone.0032195. Epub 2012 Feb 21.


Oncogenic tyrosine kinase NPM/ALK induces activation of the rapamycin-sensitive mTOR signaling pathway.

Marzec M, Kasprzycka M, Liu X, El-Salem M, Halasa K, Raghunath PN, Bucki R, Wlodarski P, Wasik MA.

Oncogene. 2007 Aug 16;26(38):5606-14. Epub 2007 Mar 12.


Rapamycin-resistant and torin-sensitive mTOR signaling promotes the survival and proliferation of leukemic cells.

Park S, Sim H, Lee K.

BMB Rep. 2016 Jan;49(1):63-8. doi: 10.5483/BMBRep.2016.49.1.201.


Hepatic insulin resistance in ob/ob mice involves increases in ceramide, aPKC activity, and selective impairment of Akt-dependent FoxO1 phosphorylation.

Sajan MP, Ivey RA, Lee MC, Farese RV.

J Lipid Res. 2015 Jan;56(1):70-80. doi: 10.1194/jlr.M052977. Epub 2014 Nov 13.


Dual inhibition of akt/mammalian target of rapamycin pathway by nanoparticle albumin-bound-rapamycin and perifosine induces antitumor activity in multiple myeloma.

Cirstea D, Hideshima T, Rodig S, Santo L, Pozzi S, Vallet S, Ikeda H, Perrone G, Gorgun G, Patel K, Desai N, Sportelli P, Kapoor S, Vali S, Mukherjee S, Munshi NC, Anderson KC, Raje N.

Mol Cancer Ther. 2010 Apr;9(4):963-75. doi: 10.1158/1535-7163.MCT-09-0763. Epub 2010 Apr 6.


PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis.

Akundi RS, Zhi L, B├╝eler H.

Neurobiol Dis. 2012 Jan;45(1):469-78. doi: 10.1016/j.nbd.2011.08.034. Epub 2011 Sep 16.


Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.

Soares HP, Ni Y, Kisfalvi K, Sinnett-Smith J, Rozengurt E.

PLoS One. 2013;8(2):e57289. doi: 10.1371/journal.pone.0057289. Epub 2013 Feb 21.


Rapamycin-mediated FOXO1 inactivation reduces the anticancer efficacy of rapamycin.

Abdelnour-Berchtold E, Cerantola Y, Roulin D, Dormond-Meuwly A, Demartines N, Dormond O.

Anticancer Res. 2010 Mar;30(3):799-804.


PI3K/AKT/mTOR signaling-mediated neuropeptide VGF in the hippocampus of mice is involved in the rapid onset antidepressant-like effects of GLYX-13.

Lu Y, Wang C, Xue Z, Li C, Zhang J, Zhao X, Liu A, Wang Q, Zhou W.

Int J Neuropsychopharmacol. 2014 Dec 25;18(5). pii: pyu110. doi: 10.1093/ijnp/pyu110.


Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.

Xu Q, Fitzsimmons B, Steinauer J, O'Neill A, Newton AC, Hua XY, Yaksh TL.

J Neurosci. 2011 Feb 9;31(6):2113-24. doi: 10.1523/JNEUROSCI.2139-10.2011.

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