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Items: 1 to 20 of 80

1.

Neuropeptide precursor VGF is genetically associated with social anhedonia and underrepresented in the brain of major mental illness: its downregulation by DISC1.

Ramos A, Rodríguez-Seoane C, Rosa I, Trossbach SV, Ortega-Alonso A, Tomppo L, Ekelund J, Veijola J, Järvelin MR, Alonso J, Veiga S, Sawa A, Hennah W, García A, Korth C, Requena JR.

Hum Mol Genet. 2014 Nov 15;23(22):5859-65. doi: 10.1093/hmg/ddu303.

2.

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.

Thomson PA, Parla JS, McRae AF, Kramer M, Ramakrishnan K, Yao J, Soares DC, McCarthy S, Morris SW, Cardone L, Cass S, Ghiban E, Hennah W, Evans KL, Rebolini D, Millar JK, Harris SE, Starr JM, MacIntyre DJ; Generation Scotland., McIntosh AM, Watson JD, Deary IJ, Visscher PM, Blackwood DH, McCombie WR, Porteous DJ.

Mol Psychiatry. 2014 Jun;19(6):668-75. doi: 10.1038/mp.2013.68.

3.

DISC1 regulates expression of the neurotrophin VGF through the PI3K/AKT/CREB pathway.

Rodríguez-Seoane C, Ramos A, Korth C, Requena JR.

J Neurochem. 2015 Nov;135(3):598-605. doi: 10.1111/jnc.13258.

4.

Disrupted-in-schizophrenia-1 (DISC1): a key susceptibility factor for major mental illnesses.

Sawamura N, Sawa A.

Ann N Y Acad Sci. 2006 Nov;1086:126-33. Review.

PMID:
17185511
5.

Regulation of the cytoskeleton by Disrupted-in-schizophrenia 1 (DISC1).

Wang Q, Brandon NJ.

Mol Cell Neurosci. 2011 Dec;48(4):359-64. doi: 10.1016/j.mcn.2011.06.004. Review.

PMID:
21757008
6.

Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder.

Maeda K, Nwulia E, Chang J, Balkissoon R, Ishizuka K, Chen H, Zandi P, McInnis MG, Sawa A.

Biol Psychiatry. 2006 Nov 1;60(9):929-35.

PMID:
16814263
7.

DISC1 at 10: connecting psychiatric genetics and neuroscience.

Porteous DJ, Millar JK, Brandon NJ, Sawa A.

Trends Mol Med. 2011 Dec;17(12):699-706. doi: 10.1016/j.molmed.2011.09.002. Review.

8.

The DISC locus in psychiatric illness.

Chubb JE, Bradshaw NJ, Soares DC, Porteous DJ, Millar JK.

Mol Psychiatry. 2008 Jan;13(1):36-64. Review.

PMID:
17912248
9.

Understanding the role of DISC1 in psychiatric disease and during normal development.

Brandon NJ, Millar JK, Korth C, Sive H, Singh KK, Sawa A.

J Neurosci. 2009 Oct 14;29(41):12768-75. doi: 10.1523/JNEUROSCI.3355-09.2009. Review.

10.

The expression of VGF is reduced in leukocytes of depressed patients and it is restored by effective antidepressant treatment.

Cattaneo A, Sesta A, Calabrese F, Nielsen G, Riva MA, Gennarelli M.

Neuropsychopharmacology. 2010 Jun;35(7):1423-8. doi: 10.1038/npp.2010.11.

11.

Synaptic dysregulation in a human iPS cell model of mental disorders.

Wen Z, Nguyen HN, Guo Z, Lalli MA, Wang X, Su Y, Kim NS, Yoon KJ, Shin J, Zhang C, Makri G, Nauen D, Yu H, Guzman E, Chiang CH, Yoritomo N, Kaibuchi K, Zou J, Christian KM, Cheng L, Ross CA, Margolis RL, Chen G, Kosik KS, Song H, Ming GL.

Nature. 2014 Nov 20;515(7527):414-8. doi: 10.1038/nature13716.

12.

Linking neurodevelopmental and synaptic theories of mental illness through DISC1.

Brandon NJ, Sawa A.

Nat Rev Neurosci. 2011 Nov 18;12(12):707-22. doi: 10.1038/nrn3120. Review.

13.

Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder.

Song W, Li W, Noltner K, Yan J, Green E, Grozeva D, Jones IR, Craddock N, Longmate J, Feng J, Sommer SS.

Neurosci Lett. 2010 Dec 17;486(3):136-40. doi: 10.1016/j.neulet.2010.09.027. Review.

PMID:
20850505
14.

The neuropeptide VGF is reduced in human bipolar postmortem brain and contributes to some of the behavioral and molecular effects of lithium.

Thakker-Varia S, Jean YY, Parikh P, Sizer CF, Jernstedt Ayer J, Parikh A, Hyde TM, Buyske S, Alder J.

J Neurosci. 2010 Jul 14;30(28):9368-80. doi: 10.1523/JNEUROSCI.5987-09.2010.

15.

The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.

Hennah W, Porteous D.

PLoS One. 2009;4(3):e4906. doi: 10.1371/journal.pone.0004906.

16.

Molecular mechanism of schizophrenia with reference to disrupted-in-schizophrenia 1 (DISC1).

Matsuzaki S, Tohyama M.

Neurochem Int. 2007 Jul-Sep;51(2-4):165-72. Review.

PMID:
17664024
17.

Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs.

Lipska BK, Peters T, Hyde TM, Halim N, Horowitz C, Mitkus S, Weickert CS, Matsumoto M, Sawa A, Straub RE, Vakkalanka R, Herman MM, Weinberger DR, Kleinman JE.

Hum Mol Genet. 2006 Apr 15;15(8):1245-58.

18.

Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population.

Thomson PA, Wray NR, Millar JK, Evans KL, Hellard SL, Condie A, Muir WJ, Blackwood DH, Porteous DJ.

Mol Psychiatry. 2005 Jul;10(7):657-68, 616.

PMID:
15838535
19.

Utility and validity of DISC1 mouse models in biological psychiatry.

Tomoda T, Sumitomo A, Jaaro-Peled H, Sawa A.

Neuroscience. 2016 May 3;321:99-107. doi: 10.1016/j.neuroscience.2015.12.061. Review.

PMID:
26768401
20.

Aggregated proteins in schizophrenia and other chronic mental diseases: DISC1opathies.

Korth C.

Prion. 2012 Apr-Jun;6(2):134-41. doi: 10.4161/pri.18989. Review.

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