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Abnormally differentiating keratinocytes in the epidermis of systemic sclerosis patients show enhanced secretion of CCN2 and S100A9.

Nikitorowicz-Buniak J, Shiwen X, Denton CP, Abraham D, Stratton R.

J Invest Dermatol. 2014 Nov;134(11):2693-702. doi: 10.1038/jid.2014.253.


Epithelial cells promote fibroblast activation via IL-1alpha in systemic sclerosis.

Aden N, Nuttall A, Shiwen X, de Winter P, Leask A, Black CM, Denton CP, Abraham DJ, Stratton RJ.

J Invest Dermatol. 2010 Sep;130(9):2191-200. doi: 10.1038/jid.2010.120.


Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)/transforming growth factor β-dependent mesenchymal-to-mesenchymal transition.

Serratì S, Chillà A, Laurenzana A, Margheri F, Giannoni E, Magnelli L, Chiarugi P, Dotor J, Feijoo E, Bazzichi L, Bombardieri S, Kahaleh B, Fibbi G, Del Rosso M.

Arthritis Rheum. 2013 Jan;65(1):258-69. doi: 10.1002/art.37705.


The fibrotic phenotype of systemic sclerosis fibroblasts varies with disease duration and severity of skin involvement: reconstitution of skin fibrosis development using a tissue engineering approach.

Corriveau MP, Boufaied I, Lessard J, Chabaud S, Senécal JL, Grodzicky T, Chartier S, Raymond Y, Moulin VJ.

J Pathol. 2009 Mar;217(4):534-42. doi: 10.1002/path.2482.


Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis.

Distler JH, Jüngel A, Kowal-Bielecka O, Michel BA, Gay RE, Sprott H, Matucci-Cerinic M, Chilla M, Reich K, Kalden JR, Müller-Ladner U, Lorenz HM, Gay S, Distler O.

Arthritis Rheum. 2005 Mar;52(3):856-64.


S100A8 and S100A9 Are Induced by Decreased Hydration in the Epidermis and Promote Fibroblast Activation and Fibrosis in the Dermis.

Zhong A, Xu W, Zhao J, Xie P, Jia S, Sun J, Galiano RD, Mustoe TA, Hong SJ.

Am J Pathol. 2016 Jan;186(1):109-22. doi: 10.1016/j.ajpath.2015.09.005.


Elevated expression of cav-1 in a subset of SSc fibroblasts contributes to constitutive Alk1/Smad1 activation.

Haines P, Hant FN, Lafyatis R, Trojanowska M, Bujor AM.

J Cell Mol Med. 2012 Sep;16(9):2238-46. doi: 10.1111/j.1582-4934.2012.01537.x.


S100A8 and S100A9 are messengers in the crosstalk between epidermis and dermis modulating a psoriatic milieu in human skin.

Lee Y, Jang S, Min JK, Lee K, Sohn KC, Lim JS, Im M, Lee HE, Seo YJ, Kim CD, Lee JH.

Biochem Biophys Res Commun. 2012 Jul 13;423(4):647-53. doi: 10.1016/j.bbrc.2012.05.162.


Smad1 pathway is activated in systemic sclerosis fibroblasts and is targeted by imatinib mesylate.

Pannu J, Asano Y, Nakerakanti S, Smith E, Jablonska S, Blaszczyk M, ten Dijke P, Trojanowska M.

Arthritis Rheum. 2008 Aug;58(8):2528-37. doi: 10.1002/art.23698.


CD109 overexpression ameliorates skin fibrosis in a mouse model of bleomycin-induced scleroderma.

Vorstenbosch J, Al-Ajmi H, Winocour S, Trzeciak A, Lessard L, Philip A.

Arthritis Rheum. 2013 May;65(5):1378-83. doi: 10.1002/art.37907.


Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis.

Del Galdo F, Sotgia F, de Almeida CJ, Jasmin JF, Musick M, Lisanti MP, Jiménez SA.

Arthritis Rheum. 2008 Sep;58(9):2854-65. doi: 10.1002/art.23791.


Induction of matrix metalloproteinase-1 by small interfering RNA targeting connective tissue growth factor in dermal fibroblasts from patients with systemic sclerosis.

Ishibuchi H, Abe M, Yokoyama Y, Ishikawa O.

Exp Dermatol. 2010 Aug;19(8):e111-6. doi: 10.1111/j.1600-0625.2009.00999.x.


The antimicrobial heterodimer S100A8/S100A9 (calprotectin) is upregulated by bacterial flagellin in human epidermal keratinocytes.

Abtin A, Eckhart L, Gläser R, Gmeiner R, Mildner M, Tschachler E.

J Invest Dermatol. 2010 Oct;130(10):2423-30. doi: 10.1038/jid.2010.158.


Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma.

Sonnylal S, Denton CP, Zheng B, Keene DR, He R, Adams HP, Vanpelt CS, Geng YJ, Deng JM, Behringer RR, de Crombrugghe B.

Arthritis Rheum. 2007 Jan;56(1):334-44.


A profibrotic role for thymic stromal lymphopoietin in systemic sclerosis.

Usategui A, Criado G, Izquierdo E, Del Rey MJ, Carreira PE, Ortiz P, Leonard WJ, Pablos JL.

Ann Rheum Dis. 2013 Dec;72(12):2018-23. doi: 10.1136/annrheumdis-2012-202279.


High IL-17E and low IL-17C dermal expression identifies a fibrosis-specific motif common to morphea and systemic sclerosis.

Lonati PA, Brembilla NC, Montanari E, Fontao L, Gabrielli A, Vettori S, Valentini G, Laffitte E, Kaya G, Meroni PL, Chizzolini C.

PLoS One. 2014 Aug 19;9(8):e105008. doi: 10.1371/journal.pone.0105008.


MicroRNA-29a induces apoptosis via increasing the Bax:Bcl-2 ratio in dermal fibroblasts of patients with systemic sclerosis.

Jafarinejad-Farsangi S, Farazmand A, Mahmoudi M, Gharibdoost F, Karimizadeh E, Noorbakhsh F, Faridani H, Jamshidi AR.

Autoimmunity. 2015;48(6):369-78. doi: 10.3109/08916934.2015.1030616.


Role of endothelin-1 in the skin fibrosis of systemic sclerosis.

Jing J, Dou TT, Yang JQ, Chen XB, Cao HL, Min M, Cai SQ, Zheng M, Man XY.

Eur Cytokine Netw. 2015 Jan-Mar;26(1):10-4. doi: 10.1684/ecn.2015.0360.


Partially Evoked Epithelial-Mesenchymal Transition (EMT) Is Associated with Increased TGFβ Signaling within Lesional Scleroderma Skin.

Nikitorowicz-Buniak J, Denton CP, Abraham D, Stratton R.

PLoS One. 2015 Jul 28;10(7):e0134092. doi: 10.1371/journal.pone.0134092.

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