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Items: 1 to 20 of 93


Folded small molecule manipulation of islet amyloid polypeptide.

Kumar S, Brown MA, Nath A, Miranker AD.

Chem Biol. 2014 Jun 19;21(6):775-81. doi: 10.1016/j.chembiol.2014.05.007. Epub 2014 Jun 12.


Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics.

Kumar S, Schlamadinger DE, Brown MA, Dunn JM, Mercado B, Hebda JA, Saraogi I, Rhoades E, Hamilton AD, Miranker AD.

Chem Biol. 2015 Mar 19;22(3):369-78. doi: 10.1016/j.chembiol.2015.01.006. Epub 2015 Mar 5.


Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin.

Kumar S, Birol M, Miranker AD.

Chem Commun (Camb). 2016 May 11;52(38):6391-4. doi: 10.1039/c6cc01248e. Epub 2016 Apr 15.


Peptide amyloid surface display.

Rubio MA, Schlamadinger DE, White EM, Miranker AD.

Biochemistry. 2015 Feb 3;54(4):987-93. doi: 10.1021/bi5011442. Epub 2015 Jan 20.


A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.

Kumar S, Miranker AD.

Chem Commun (Camb). 2013 May 25;49(42):4749-51. doi: 10.1039/c3cc41452c.


Small molecule screening in context: lipid-catalyzed amyloid formation.

Hebda JA, Magzoub M, Miranker AD.

Protein Sci. 2014 Oct;23(10):1341-8. doi: 10.1002/pro.2518. Epub 2014 Jul 28.


Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.

Cao P, Marek P, Noor H, Patsalo V, Tu LH, Wang H, Abedini A, Raleigh DP.

FEBS Lett. 2013 Apr 17;587(8):1106-18. doi: 10.1016/j.febslet.2013.01.046. Epub 2013 Feb 1. Review.


Low pH acts as inhibitor of membrane damage induced by human islet amyloid polypeptide.

Khemtémourian L, Doménech E, Doux JP, Koorengevel MC, Killian JA.

J Am Chem Soc. 2011 Oct 5;133(39):15598-604. doi: 10.1021/ja205007j. Epub 2011 Sep 9.


Binding of islet amyloid polypeptide to supported lipid bilayers and amyloid aggregation at the membranes.

Sasahara K, Morigaki K, Okazaki T, Hamada D.

Biochemistry. 2012 Sep 4;51(35):6908-19. doi: 10.1021/bi300542g. Epub 2012 Aug 23.


Evaluation of membrane models and their composition for islet amyloid polypeptide-membrane aggregation.

Caillon L, Lequin O, Khemtémourian L.

Biochim Biophys Acta. 2013 Sep;1828(9):2091-8. doi: 10.1016/j.bbamem.2013.05.014. Epub 2013 May 23.


Helix stabilization precedes aqueous and bilayer-catalyzed fiber formation in islet amyloid polypeptide.

Williamson JA, Loria JP, Miranker AD.

J Mol Biol. 2009 Oct 23;393(2):383-96. doi: 10.1016/j.jmb.2009.07.077. Epub 2009 Jul 30.


Islet amyloid polypeptide demonstrates a persistent capacity to disrupt membrane integrity.

Last NB, Rhoades E, Miranker AD.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9460-5. doi: 10.1073/pnas.1102356108. Epub 2011 May 23.


Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology.

Cao P, Abedini A, Raleigh DP.

Curr Opin Struct Biol. 2013 Feb;23(1):82-9. doi: 10.1016/ Epub 2012 Dec 22. Review.


Islet amyloid polypeptide: aggregation and fibrillogenesis in vitro and its inhibition.

Seeliger J, Winter R.

Subcell Biochem. 2012;65:185-209. doi: 10.1007/978-94-007-5416-4_8. Review.


Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions.

Susa AC, Wu C, Bernstein SL, Dupuis NF, Wang H, Raleigh DP, Shea JE, Bowers MT.

J Am Chem Soc. 2014 Sep 17;136(37):12912-9. doi: 10.1021/ja504031d. Epub 2014 Sep 4.


A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes.

Hebda JA, Saraogi I, Magzoub M, Hamilton AD, Miranker AD.

Chem Biol. 2009 Sep 25;16(9):943-50. doi: 10.1016/j.chembiol.2009.08.013.


Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective.

Brender JR, Salamekh S, Ramamoorthy A.

Acc Chem Res. 2012 Mar 20;45(3):454-62. doi: 10.1021/ar200189b. Epub 2011 Sep 25.


Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus.

Jeong HR, An SS.

Clin Interv Aging. 2015 Nov 19;10:1873-9. doi: 10.2147/CIA.S95297. eCollection 2015. Review.


Effects of cholesterol on pore formation in lipid bilayers induced by human islet amyloid polypeptide fragments: a coarse-grained molecular dynamics study.

Xu W, Wei G, Su H, Nordenskiöld L, Mu Y.

Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Nov;84(5 Pt 1):051922. Epub 2011 Nov 29.


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