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Items: 1 to 20 of 73


PME-1 modulates protein phosphatase 2A activity to promote the malignant phenotype of endometrial cancer cells.

Wandzioch E, Pusey M, Werda A, Bail S, Bhaskar A, Nestor M, Yang JJ, Rice LM.

Cancer Res. 2014 Aug 15;74(16):4295-305. doi: 10.1158/0008-5472.CAN-13-3130. Epub 2014 Jun 13.


Inhibition of protein methylesterase 1 decreased cancerous phenotypes in endometrial adenocarcinoma cell lines and xenograft tumor models.

Pusey M, Bail S, Xu Y, Buiakova O, Nestor M, Yang JJ, Rice LM.

Tumour Biol. 2016 Sep;37(9):11835-11842. Epub 2016 Apr 5.


Spatial control of protein phosphatase 2A (de)methylation.

Longin S, Zwaenepoel K, Martens E, Louis JV, Rondelez E, Goris J, Janssens V.

Exp Cell Res. 2008 Jan 1;314(1):68-81. Epub 2007 Aug 7.


PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.

Puustinen P, Junttila MR, Vanhatupa S, Sablina AA, Hector ME, Teittinen K, Raheem O, Ketola K, Lin S, Kast J, Haapasalo H, Hahn WC, Westermarck J.

Cancer Res. 2009 Apr 1;69(7):2870-7. doi: 10.1158/0008-5472.CAN-08-2760. Epub 2009 Mar 17.


Structural mechanism of demethylation and inactivation of protein phosphatase 2A.

Xing Y, Li Z, Chen Y, Stock JB, Jeffrey PD, Shi Y.

Cell. 2008 Apr 4;133(1):154-63. doi: 10.1016/j.cell.2008.02.041.


Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.

Yabe R, Miura A, Usui T, Mudrak I, Ogris E, Ohama T, Sato K.

PLoS One. 2015 Dec 17;10(12):e0145226. doi: 10.1371/journal.pone.0145226. eCollection 2015.


Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice.

Ortega-Gutiérrez S, Leung D, Ficarro S, Peters EC, Cravatt BF.

PLoS One. 2008 Jul 2;3(7):e2486. doi: 10.1371/journal.pone.0002486.


Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.

Kloeker S, Reed R, McConnell JL, Chang D, Tran K, Westphal RS, Law BK, Colbran RJ, Kamoun M, Campbell KS, Wadzinski BE.

Protein Expr Purif. 2003 Sep;31(1):19-33.


Carnosic acid stimulates glucose uptake in skeletal muscle cells via a PME-1/PP2A/PKB signalling axis.

Lipina C, Hundal HS.

Cell Signal. 2014 Nov;26(11):2343-9. doi: 10.1016/j.cellsig.2014.07.022. Epub 2014 Jul 17.


Glycogen synthase kinase-3β regulates leucine-309 demethylation of protein phosphatase-2A via PPMT1 and PME-1.

Yao XQ, Li XC, Zhang XX, Yin YY, Liu B, Luo DJ, Wang Q, Wang JZ, Liu GP.

FEBS Lett. 2012 Jul 30;586(16):2522-8. doi: 10.1016/j.febslet.2012.06.018. Epub 2012 Jun 22.


Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).

Ikehara T, Ikehara S, Imamura S, Shinjo F, Yasumoto T.

Biochem Biophys Res Commun. 2007 Mar 23;354(4):1052-7. Epub 2007 Jan 24.


Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer.

Kaur A, Elzagheid A, Birkman EM, Avoranta T, Kytölä V, Korkeila E, Syrjänen K, Westermarck J, Sundström J.

Cancer Med. 2015 Dec;4(12):1798-808. doi: 10.1002/cam4.541. Epub 2015 Sep 17.


The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity.

Sents W, Ivanova E, Lambrecht C, Haesen D, Janssens V.

FEBS J. 2013 Jan;280(2):644-61. doi: 10.1111/j.1742-4658.2012.08579.x. Epub 2012 Apr 25. Review.


Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6. doi: 10.1073/pnas.1015248108. Epub 2011 Mar 11.


Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1.

Kaur A, Westermarck J.

Biochem Soc Trans. 2016 Dec 15;44(6):1683-1693. Review.


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