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An iron-regulated and glycosylation-dependent proteasomal degradation pathway for the plasma membrane metal transporter ZIP14.

Zhao N, Zhang AS, Worthen C, Knutson MD, Enns CA.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9175-80. doi: 10.1073/pnas.1405355111. Epub 2014 Jun 9.


Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells.

Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJ.

Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13612-7. Epub 2006 Sep 1.


ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin.

Zhao N, Gao J, Enns CA, Knutson MD.

J Biol Chem. 2010 Oct 15;285(42):32141-50. doi: 10.1074/jbc.M110.143248. Epub 2010 Aug 3.


The plasma membrane metal-ion transporter ZIP14 contributes to nontransferrin-bound iron uptake by human β-cells.

Coffey R, Knutson MD.

Am J Physiol Cell Physiol. 2017 Feb 1;312(2):C169-C175. doi: 10.1152/ajpcell.00116.2016. Epub 2016 Nov 30.


Zinc transporter ZIP14 functions in hepatic zinc, iron and glucose homeostasis during the innate immune response (endotoxemia).

Aydemir TB, Chang SM, Guthrie GJ, Maki AB, Ryu MS, Karabiyik A, Cousins RJ.

PLoS One. 2012;7(10):e48679. doi: 10.1371/journal.pone.0048679. Epub 2012 Oct 24.


Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron.

Pinilla-Tenas JJ, Sparkman BK, Shawki A, Illing AC, Mitchell CJ, Zhao N, Liuzzi JP, Cousins RJ, Knutson MD, Mackenzie B.

Am J Physiol Cell Physiol. 2011 Oct;301(4):C862-71. doi: 10.1152/ajpcell.00479.2010. Epub 2011 Jun 8.


ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading.

Wang CY, Jenkitkasemwong S, Duarte S, Sparkman BK, Shawki A, Mackenzie B, Knutson MD.

J Biol Chem. 2012 Oct 5;287(41):34032-43. doi: 10.1074/jbc.M112.367284. Epub 2012 Aug 16.


Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter.

Girijashanker K, He L, Soleimani M, Reed JM, Li H, Liu Z, Wang B, Dalton TP, Nebert DW.

Mol Pharmacol. 2008 May;73(5):1413-23. doi: 10.1124/mol.107.043588. Epub 2008 Feb 12. Erratum in: Mol Pharmacol. 2008 Sep;74(3):924.


Molecular and cellular mechanisms underlying iron transport deficiency in microcytic anemia.

Touret N, Martin-Orozco N, Paroutis P, Furuya W, Lam-Yuk-Tseung S, Forbes J, Gros P, Grinstein S.

Blood. 2004 Sep 1;104(5):1526-33. Epub 2004 May 20.


Prion protein functions as a ferrireductase partner for ZIP14 and DMT1.

Tripathi AK, Haldar S, Qian J, Beserra A, Suda S, Singh A, Hopfer U, Chen SG, Garrick MD, Turner JR, Knutson MD, Singh N.

Free Radic Biol Med. 2015 Jul;84:322-330. doi: 10.1016/j.freeradbiomed.2015.03.037. Epub 2015 Apr 8.


Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function.

Guthrie GJ, Aydemir TB, Troche C, Martin AB, Chang SM, Cousins RJ.

Am J Physiol Gastrointest Liver Physiol. 2015 Feb 1;308(3):G171-8. doi: 10.1152/ajpgi.00021.2014. Epub 2014 Nov 26. Review.


Physiologic implications of metal-ion transport by ZIP14 and ZIP8.

Jenkitkasemwong S, Wang CY, Mackenzie B, Knutson MD.

Biometals. 2012 Aug;25(4):643-55. doi: 10.1007/s10534-012-9526-x. Epub 2012 Feb 9. Review.


Metal Transporter Zip14 (Slc39a14) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity.

Aydemir TB, Kim MH, Kim J, Colon-Perez LM, Banan G, Mareci TH, Febo M, Cousins RJ.

J Neurosci. 2017 Jun 21;37(25):5996-6006. doi: 10.1523/JNEUROSCI.0285-17.2017. Epub 2017 May 23.


Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation.

Brasse-Lagnel C, Karim Z, Letteron P, Bekri S, Bado A, Beaumont C.

Gastroenterology. 2011 Apr;140(4):1261-1271.e1. doi: 10.1053/j.gastro.2010.12.037. Epub 2011 Jan 1.


Homeostatic regulation of trace mineral transport by ubiquitination of membrane transporters.

Hennigar SR, McClung JP.

Nutr Rev. 2016 Jan;74(1):59-67. doi: 10.1093/nutrit/nuv060. Epub 2015 Nov 26. Review.


Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14.

Taylor KM, Morgan HE, Johnson A, Nicholson RI.

FEBS Lett. 2005 Jan 17;579(2):427-32.


Monoubiquitin-dependent endocytosis of the iron-regulated transporter 1 (IRT1) transporter controls iron uptake in plants.

Barberon M, Zelazny E, Robert S, Conéjéro G, Curie C, Friml J, Vert G.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):E450-8. doi: 10.1073/pnas.1100659108. Epub 2011 May 31.


Interleukin-1beta contributes via nitric oxide to the upregulation and functional activity of the zinc transporter Zip14 (Slc39a14) in murine hepatocytes.

Lichten LA, Liuzzi JP, Cousins RJ.

Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G860-7. doi: 10.1152/ajpgi.90676.2008. Epub 2009 Jan 29.


The Multiple Faces of the Metal Transporter ZIP14 (SLC39A14).

Aydemir TB, Cousins RJ.

J Nutr. 2018 Feb 1;148(2):174-184. doi: 10.1093/jn/nxx041.


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