Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 101

1.

Structural heterogeneity in transmembrane amyloid precursor protein homodimer is a consequence of environmental selection.

Dominguez L, Foster L, Meredith SC, Straub JE, Thirumalai D.

J Am Chem Soc. 2014 Jul 9;136(27):9619-26. doi: 10.1021/ja503150x. Epub 2014 Jun 30.

2.

Transmembrane fragment structures of amyloid precursor protein depend on membrane surface curvature.

Dominguez L, Meredith SC, Straub JE, Thirumalai D.

J Am Chem Soc. 2014 Jan 22;136(3):854-7. doi: 10.1021/ja410958j. Epub 2014 Jan 8.

3.

Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein.

Dominguez L, Foster L, Straub JE, Thirumalai D.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):E5281-7. doi: 10.1073/pnas.1606482113. Epub 2016 Aug 24.

4.

Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase.

Winkler E, Julius A, Steiner H, Langosch D.

Biochemistry. 2015 Oct 13;54(40):6149-52. doi: 10.1021/acs.biochem.5b00986. Epub 2015 Sep 29.

PMID:
26403946
5.

Impact of bilayer lipid composition on the structure and topology of the transmembrane amyloid precursor C99 protein.

Song Y, Mittendorf KF, Lu Z, Sanders CR.

J Am Chem Soc. 2014 Mar 19;136(11):4093-6. doi: 10.1021/ja4114374. Epub 2014 Mar 11.

6.
7.

Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide.

Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, McConlogue L.

J Biol Chem. 2001 Jun 8;276(23):20267-79. Epub 2001 Mar 7.

8.

Extension of a protein docking algorithm to membranes and applications to amyloid precursor protein dimerization.

Viswanath S, Dominguez L, Foster LS, Straub JE, Elber R.

Proteins. 2015 Dec;83(12):2170-85. doi: 10.1002/prot.24934. Epub 2015 Oct 14.

9.

Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein.

Song Y, Hustedt EJ, Brandon S, Sanders CR.

Biochemistry. 2013 Jul 30;52(30):5051-64. doi: 10.1021/bi400735x. Epub 2013 Jul 18.

10.

Structural studies of the transmembrane C-terminal domain of the amyloid precursor protein (APP): does APP function as a cholesterol sensor?

Beel AJ, Mobley CK, Kim HJ, Tian F, Hadziselimovic A, Jap B, Prestegard JH, Sanders CR.

Biochemistry. 2008 Sep 9;47(36):9428-46. doi: 10.1021/bi800993c. Epub 2008 Aug 15.

11.

Perturbations of the straight transmembrane α-helical structure of the amyloid precursor protein affect its processing by γ-secretase.

Lemmin T, Dimitrov M, Fraering PC, Dal Peraro M.

J Biol Chem. 2014 Mar 7;289(10):6763-74. doi: 10.1074/jbc.M113.470781. Epub 2014 Jan 27.

12.

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.

Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S.

Acta Neuropathol Commun. 2015 Nov 4;3:66. doi: 10.1186/s40478-015-0247-6.

13.

Specific Binding of Cholesterol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail.

Nierzwicki Ł, Czub J.

J Phys Chem Lett. 2015 Mar 5;6(5):784-90. doi: 10.1021/acs.jpclett.5b00197. Epub 2015 Feb 13.

PMID:
26262653
14.

A helix-to-coil transition at the epsilon-cut site in the transmembrane dimer of the amyloid precursor protein is required for proteolysis.

Sato T, Tang TC, Reubins G, Fei JZ, Fujimoto T, Kienlen-Campard P, Constantinescu SN, Octave JN, Aimoto S, Smith SO.

Proc Natl Acad Sci U S A. 2009 Feb 3;106(5):1421-6. doi: 10.1073/pnas.0812261106. Epub 2009 Jan 21.

15.

The amyloid precursor protein C-terminal fragment C100 occurs in monomeric and dimeric stable conformations and binds γ-secretase modulators.

Botev A, Munter LM, Wenzel R, Richter L, Althoff V, Ismer J, Gerling U, Weise C, Koksch B, Hildebrand PW, Bittl R, Multhaup G.

Biochemistry. 2011 Feb 8;50(5):828-35. doi: 10.1021/bi1014002. Epub 2011 Jan 11.

PMID:
21186781
16.

The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol.

Barrett PJ, Song Y, Van Horn WD, Hustedt EJ, Schafer JM, Hadziselimovic A, Beel AJ, Sanders CR.

Science. 2012 Jun 1;336(6085):1168-71. doi: 10.1126/science.1219988.

17.

Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein.

Beel AJ, Barrett P, Schnier PD, Hitchcock SA, Bagal D, Sanders CR, Jordan JB.

Biochemistry. 2009 Dec 22;48(50):11837-9. doi: 10.1021/bi901839d.

18.

The intramembrane cleavage site of the amyloid precursor protein depends on the length of its transmembrane domain.

Lichtenthaler SF, Beher D, Grimm HS, Wang R, Shearman MS, Masters CL, Beyreuther K.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1365-70. Epub 2002 Jan 22.

19.

Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease.

Wang H, Barreyro L, Provasi D, Djemil I, Torres-Arancivia C, Filizola M, Ubarretxena-Belandia I.

J Mol Biol. 2011 May 20;408(5):879-95. doi: 10.1016/j.jmb.2011.03.028. Epub 2011 Mar 31.

20.

Dimerization and Structural Stability of Amyloid Precursor Proteins Affected by the Membrane Microenvironments.

Sun F, Chen L, Wei P, Chai M, Ding X, Xu L, Luo SZ.

J Chem Inf Model. 2017 Jun 26;57(6):1375-1387. doi: 10.1021/acs.jcim.7b00196. Epub 2017 Jun 9.

PMID:
28562045

Supplemental Content

Support Center