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Items: 1 to 20 of 142

1.

Metabolic dysfunction consistent with premature aging results from deletion of Pim kinases.

Din S, Konstandin MH, Johnson B, Emathinger J, Völkers M, Toko H, Collins B, Ormachea L, Samse K, Kubli DA, De La Torre A, Kraft AS, Gustafsson AB, Kelly DP, Sussman MA.

Circ Res. 2014 Jul 18;115(3):376-87. doi: 10.1161/CIRCRESAHA.115.304441. Epub 2014 Jun 10.

2.

The Pim protein kinases regulate energy metabolism and cell growth.

Beharry Z, Mahajan S, Zemskova M, Lin YW, Tholanikunnel BG, Xia Z, Smith CD, Kraft AS.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):528-33. doi: 10.1073/pnas.1013214108. Epub 2010 Dec 27.

3.

Peroxisome proliferator-activated receptor {delta} is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart.

Wang P, Liu J, Li Y, Wu S, Luo J, Yang H, Subbiah R, Chatham J, Zhelyabovska O, Yang Q.

Circ Res. 2010 Mar 19;106(5):911-9. doi: 10.1161/CIRCRESAHA.109.206185. Epub 2010 Jan 14.

4.

Pim-1 kinase protects mitochondrial integrity in cardiomyocytes.

Borillo GA, Mason M, Quijada P, Völkers M, Cottage C, McGregor M, Din S, Fischer K, Gude N, Avitabile D, Barlow S, Alvarez R, Truffa S, Whittaker R, Glassy MS, Gustafsson AB, Miyamoto S, Glembotski CC, Gottlieb RA, Brown JH, Sussman MA.

Circ Res. 2010 Apr 16;106(7):1265-74. doi: 10.1161/CIRCRESAHA.109.212035. Epub 2010 Mar 4.

5.

Regulating cardiac energy metabolism and bioenergetics by targeting the DNA damage repair protein BRCA1.

Singh KK, Shukla PC, Yanagawa B, Quan A, Lovren F, Pan Y, Wagg CS, Teoh H, Lopaschuk GD, Verma S.

J Thorac Cardiovasc Surg. 2013 Sep;146(3):702-9. doi: 10.1016/j.jtcvs.2012.12.046. Epub 2013 Jan 12.

6.

Deletion of Pim kinases elevates the cellular levels of reactive oxygen species and sensitizes to K-Ras-induced cell killing.

Song JH, An N, Chatterjee S, Kistner-Griffin E, Mahajan S, Mehrotra S, Kraft AS.

Oncogene. 2015 Jul;34(28):3728-36. doi: 10.1038/onc.2014.306. Epub 2014 Sep 22.

7.

Induction of heart failure by minimally invasive aortic constriction in mice: reduced peroxisome proliferator-activated receptor γ coactivator levels and mitochondrial dysfunction.

Faerber G, Barreto-Perreia F, Schoepe M, Gilsbach R, Schrepper A, Schwarzer M, Mohr FW, Hein L, Doenst T.

J Thorac Cardiovasc Surg. 2011 Feb;141(2):492-500, 500.e1. doi: 10.1016/j.jtcvs.2010.03.029. Epub 2010 May 5.

9.

Mitochondrial remodeling in mice with cardiomyocyte-specific lipid overload.

Elezaby A, Sverdlov AL, Tu VH, Soni K, Luptak I, Qin F, Liesa M, Shirihai OS, Rimer J, Schaffer JE, Colucci WS, Miller EJ.

J Mol Cell Cardiol. 2015 Feb;79:275-83. doi: 10.1016/j.yjmcc.2014.12.001. Epub 2014 Dec 9.

10.

Myocardial infarction in rats causes partial impairment in insulin response associated with reduced fatty acid oxidation and mitochondrial gene expression.

Amorim PA, Nguyen TD, Shingu Y, Schwarzer M, Mohr FW, Schrepper A, Doenst T.

J Thorac Cardiovasc Surg. 2010 Nov;140(5):1160-7. doi: 10.1016/j.jtcvs.2010.08.003. Epub 2010 Sep 17.

11.

AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development.

Hu X, Xu X, Lu Z, Zhang P, Fassett J, Zhang Y, Xin Y, Hall JL, Viollet B, Bache RJ, Huang Y, Chen Y.

Hypertension. 2011 Oct;58(4):696-703. doi: 10.1161/HYPERTENSIONAHA.111.174128. Epub 2011 Aug 8.

12.

Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.

Carraway MS, Suliman HB, Jones WS, Chen CW, Babiker A, Piantadosi CA.

Circ Res. 2010 Jun 11;106(11):1722-30. doi: 10.1161/CIRCRESAHA.109.214353. Epub 2010 Apr 15.

13.

p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.

Nakagawa Y, Kuwahara K, Takemura G, Akao M, Kato M, Arai Y, Takano M, Harada M, Murakami M, Nakanishi M, Usami S, Yasuno S, Kinoshita H, Fujiwara M, Ueshima K, Nakao K.

Circ Res. 2009 Oct 9;105(8):746-54. doi: 10.1161/CIRCRESAHA.109.206037. Epub 2009 Sep 3.

14.

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

Liao X, Zhang R, Lu Y, Prosdocimo DA, Sangwung P, Zhang L, Zhou G, Anand P, Lai L, Leone TC, Fujioka H, Ye F, Rosca MG, Hoppel CL, Schulze PC, Abel ED, Stamler JS, Kelly DP, Jain MK.

J Clin Invest. 2015 Sep;125(9):3461-76. doi: 10.1172/JCI79964. Epub 2015 Aug 4.

15.

Cardioprotection by acetylcholine: a novel mechanism via mitochondrial biogenesis and function involving the PGC-1α pathway.

Sun L, Zhao M, Yu XJ, Wang H, He X, Liu JK, Zang WJ.

J Cell Physiol. 2013 Jun;228(6):1238-48. doi: 10.1002/jcp.24277.

PMID:
23139024
16.

Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension.

Gomez-Arroyo J, Mizuno S, Szczepanek K, Van Tassell B, Natarajan R, dos Remedios CG, Drake JI, Farkas L, Kraskauskas D, Wijesinghe DS, Chalfant CE, Bigbee J, Abbate A, Lesnefsky EJ, Bogaard HJ, Voelkel NF.

Circ Heart Fail. 2013 Jan;6(1):136-44. doi: 10.1161/CIRCHEARTFAILURE.111.966127. Epub 2012 Nov 14.

17.

Mitochondrial aldehyde dehydrogenase 2 accentuates aging-induced cardiac remodeling and contractile dysfunction: role of AMPK, Sirt1, and mitochondrial function.

Zhang Y, Mi SL, Hu N, Doser TA, Sun A, Ge J, Ren J.

Free Radic Biol Med. 2014 Jun;71:208-20. doi: 10.1016/j.freeradbiomed.2014.03.018. Epub 2014 Mar 24.

18.

Obesity-induced cardiac lipid accumulation in adult mice is modulated by G protein-coupled receptor kinase 2 levels.

Lucas E, Vila-Bedmar R, Arcones AC, Cruces-Sande M, Cachofeiro V, Mayor F Jr, Murga C.

Cardiovasc Diabetol. 2016 Nov 10;15(1):155.

19.

Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload.

Muraski JA, Fischer KM, Wu W, Cottage CT, Quijada P, Mason M, Din S, Gude N, Alvarez R Jr, Rota M, Kajstura J, Wang Z, Schaefer E, Chen X, MacDonnel S, Magnuson N, Houser SR, Anversa P, Sussman MA.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13889-94. doi: 10.1073/pnas.0709135105. Epub 2008 Sep 10.

20.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16.

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