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Intracellular cleavage of amyloid β by a viral protease NIa prevents amyloid β-mediated cytotoxicity.

Shin B, Oh H, Park SM, Han HE, Ye M, Song WK, Park WJ.

PLoS One. 2014 Jun 10;9(6):e98650. doi: 10.1371/journal.pone.0098650. eCollection 2014.


The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-β.

Han HE, Sellamuthu S, Shin BH, Lee YJ, Song S, Seo JS, Baek IS, Bae J, Kim H, Yoo YJ, Jung YK, Song WK, Han PL, Park WJ.

PLoS One. 2010 Dec 20;5(12):e15645. doi: 10.1371/journal.pone.0015645.


Expression of the plant viral protease NIa in the brain of a mouse model of Alzheimer's disease mitigates Aβ pathology and improves cognitive function.

Kim TK, Han HE, Kim H, Lee JE, Choi D, Park WJ, Han PL.

Exp Mol Med. 2012 Dec 31;44(12):740-8. doi: 10.3858/emm.2012.44.12.082.


Mitochondria-targeted catalase reduces abnormal APP processing, amyloid β production and BACE1 in a mouse model of Alzheimer's disease: implications for neuroprotection and lifespan extension.

Mao P, Manczak M, Calkins MJ, Truong Q, Reddy TP, Reddy AP, Shirendeb U, Lo HH, Rabinovitch PS, Reddy PH.

Hum Mol Genet. 2012 Jul 1;21(13):2973-90. doi: 10.1093/hmg/dds128. Epub 2012 Apr 5.


PKCε promotes HuD-mediated neprilysin mRNA stability and enhances neprilysin-induced Aβ degradation in brain neurons.

Lim CS, Alkon DL.

PLoS One. 2014 May 21;9(5):e97756. doi: 10.1371/journal.pone.0097756. eCollection 2014.


A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice.

Devi L, Ohno M.

Mol Brain. 2015 Mar 25;8:19. doi: 10.1186/s13041-015-0110-5.


Neprilysin deficiency alters the neuropathological and behavioral phenotype in the 5XFAD mouse model of Alzheimer's disease.

Hüttenrauch M, Baches S, Gerth J, Bayer TA, Weggen S, Wirths O.

J Alzheimers Dis. 2015;44(4):1291-302. doi: 10.3233/JAD-142463.


Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.

Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ.

Am J Pathol. 2007 Jul;171(1):241-51.


HIV-1 reduces Abeta-degrading enzymatic activities in primary human mononuclear phagocytes.

Lan X, Xu J, Kiyota T, Peng H, Zheng JC, Ikezu T.

J Immunol. 2011 Jun 15;186(12):6925-32. doi: 10.4049/jimmunol.1100211. Epub 2011 May 6.


Recombinant soluble neprilysin reduces amyloid-beta accumulation and improves memory impairment in Alzheimer's disease mice.

Park MH, Lee JK, Choi S, Ahn J, Jin HK, Park JS, Bae JS.

Brain Res. 2013 Sep 5;1529:113-24. doi: 10.1016/j.brainres.2013.05.045. Epub 2013 Jul 2.


Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin.

Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM.

Neurobiol Dis. 2008 Sep;31(3):442-50. doi: 10.1016/j.nbd.2008.06.001. Epub 2008 Jun 17.


Neprilysin protects neurons against Abeta peptide toxicity.

El-Amouri SS, Zhu H, Yu J, Gage FH, Verma IM, Kindy MS.

Brain Res. 2007 Jun 4;1152:191-200. Epub 2007 Mar 28.


Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease.

Rockenstein E, Torrance M, Mante M, Adame A, Paulino A, Rose JB, Crews L, Moessler H, Masliah E.

J Neurosci Res. 2006 May 15;83(7):1252-61.


Neprilysin protects against cerebral amyloid angiopathy and Aβ-induced degeneration of cerebrovascular smooth muscle cells.

Miners JS, Kehoe P, Love S.

Brain Pathol. 2011 Sep;21(5):594-605. doi: 10.1111/j.1750-3639.2011.00486.x. Epub 2011 Apr 3.


Donepezil attenuates Aβ-associated mitochondrial dysfunction and reduces mitochondrial Aβ accumulation in vivo and in vitro.

Ye CY, Lei Y, Tang XC, Zhang HY.

Neuropharmacology. 2015 Aug;95:29-36. doi: 10.1016/j.neuropharm.2015.02.020. Epub 2015 Mar 3.


GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.

Tian J, Shi J, Zhang L, Yin J, Hu Q, Xu Y, Sheng S, Wang P, Ren Y, Wang R, Wang Y.

Curr Alzheimer Res. 2009 Apr;6(2):118-31.


Mitochondrial import and degradation of amyloid-β peptide.

Pinho CM, Teixeira PF, Glaser E.

Biochim Biophys Acta. 2014 Jul;1837(7):1069-74. doi: 10.1016/j.bbabio.2014.02.007. Epub 2014 Feb 18. Review.


Neprilysin-2 is an important β-amyloid degrading enzyme.

Hafez D, Huang JY, Huynh AM, Valtierra S, Rockenstein E, Bruno AM, Lu B, DesGroseillers L, Masliah E, Marr RA.

Am J Pathol. 2011 Jan;178(1):306-12. doi: 10.1016/j.ajpath.2010.11.012. Epub 2010 Dec 23.


Effects of HNE-modification induced by Abeta on neprilysin expression and activity in SH-SY5Y cells.

Wang R, Wang S, Malter JS, Wang DS.

J Neurochem. 2009 Feb;108(4):1072-82. doi: 10.1111/j.1471-4159.2008.05855.x.


Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

Hemming ML, Patterson M, Reske-Nielsen C, Lin L, Isacson O, Selkoe DJ.

PLoS Med. 2007 Aug;4(8):e262.

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