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Items: 1 to 20 of 119

2.
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Synthesis and antitumor activity evaluation of a novel combi-nitrosourea prodrug: Designed to release a DNA cross-linking agent and an inhibitor of O(6)-alkylguanine-DNA alkyltransferase.

Sun G, Zhang N, Zhao L, Fan T, Zhang S, Zhong R.

Bioorg Med Chem. 2016 May 1;24(9):2097-107. doi: 10.1016/j.bmc.2016.03.041.

PMID:
27041398
5.

Synthesis and Antitumor Activity Evaluation of a Novel Combi-nitrosourea Prodrug: BGCNU.

Wang Y, Ren T, Lai X, Sun G, Zhao L, Zhang N, Zhong R.

ACS Med Chem Lett. 2017 Jan 13;8(2):174-178. doi: 10.1021/acsmedchemlett.6b00358.

PMID:
28197307
6.

Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA.

Kotandeniya D, Murphy D, Seneviratne U, Guza R, Pegg A, Kanugula S, Tretyakova N.

Chem Res Toxicol. 2011 Nov 21;24(11):1966-75. doi: 10.1021/tx2002993.

7.

Acquired resistance to O6-benzylguanine plus chloroethylnitrosoureas in human breast cancer.

Phillips WP Jr, Gerson SL.

Cancer Chemother Pharmacol. 1999;44(4):319-26.

PMID:
10447580
8.
9.

Quantification of meCCNU-induced dG-dC crosslinks in oligonucleotide duplexes by liquid chromatography/electrospray ionization tandem mass spectrometry.

Bai B, Zhao L, Zhong R.

Rapid Commun Mass Spectrom. 2011 Jul 30;25(14):2027-34. doi: 10.1002/rcm.5064.

PMID:
21698685
10.

Measurement of O(6)-alkylguanine-DNA alkyltransferase activity in tumour cells using stable isotope dilution HPLC-ESI-MS/MS.

Sun G, Zhao L, Fan T, Ren T, Zhong R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:138-46. doi: 10.1016/j.jchromb.2016.08.010.

PMID:
27544051
12.

Enhancement of platinum-induced cytotoxicity by O6-benzylguanine.

Fishel ML, Delaney SM, Friesen LD, Hansen RJ, Zuhowski EG, Moschel RC, Egorin MJ, Dolan ME.

Mol Cancer Ther. 2003 Jul;2(7):633-40.

13.
14.

DNA alkylation products formed by 1-(2-chloroethyl)-1-nitrosourea as molecular dosimeters of therapeutic response.

Bodell WJ.

J Neurooncol. 2009 Feb;91(3):257-64. doi: 10.1007/s11060-008-9715-1.

PMID:
18979209
15.

Interrelationship between O6-alkylguanine-DNA alkyltransferase activity and susceptibility to chloroethylnitrosoureas in several glioma cell lines.

Hotta T, Saito Y, Mikami T, Kurisu K, Kiya K, Uozumi T, Isowa G, Ishizaki K, Ikenaga M.

J Neurooncol. 1993 Jul;17(1):1-8.

PMID:
8120566
16.

Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase.

Kotandeniya D, Murphy D, Yan S, Park S, Seneviratne U, Koopmeiners JS, Pegg A, Kanugula S, Kassie F, Tretyakova N.

Biochemistry. 2013 Jun 11;52(23):4075-88. doi: 10.1021/bi4004952.

17.

Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides.

Guza R, Ma L, Fang Q, Pegg AE, Tretyakova N.

J Biol Chem. 2009 Aug 21;284(34):22601-10. doi: 10.1074/jbc.M109.000919.

18.

Role of base excision repair in protecting cells from the toxicity of chloroethylnitrosoureas.

Ludlum DB, Li Q, Matijasevic Z.

IARC Sci Publ. 1999;(150):271-7.

PMID:
10626227
20.

Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents.

Dolan ME, Mitchell RB, Mummert C, Moschel RC, Pegg AE.

Cancer Res. 1991 Jul 1;51(13):3367-72.

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