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Mechanisms that can promote peripheral B-cell lymphoma in ATM-deficient mice.

Tepsuporn S, Hu J, Gostissa M, Alt FW.

Cancer Immunol Res. 2014 Sep;2(9):857-66. doi: 10.1158/2326-6066.CIR-14-0090. Epub 2014 Jun 9.


Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes.

Hu J, Tepsuporn S, Meyers RM, Gostissa M, Alt FW.

Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10269-74. doi: 10.1073/pnas.1410112111. Epub 2014 Jun 30.


Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching.

Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, Coakley KM, Rajewsky K, Manis JP, Yan CT.

J Exp Med. 2008 Dec 22;205(13):3079-90. doi: 10.1084/jem.20082271. Epub 2008 Dec 8.


Long-range oncogenic activation of Igh-c-myc translocations by the Igh 3' regulatory region.

Gostissa M, Yan CT, Bianco JM, Cogné M, Pinaud E, Alt FW.

Nature. 2009 Dec 10;462(7274):803-7. doi: 10.1038/nature08633.


Mechanisms promoting translocations in editing and switching peripheral B cells.

Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW.

Nature. 2009 Jul 9;460(7252):231-6. doi: 10.1038/nature08159.


ATM damage response and XLF repair factor are functionally redundant in joining DNA breaks.

Zha S, Guo C, Boboila C, Oksenych V, Cheng HL, Zhang Y, Wesemann DR, Yuen G, Patel H, Goff PH, Dubois RL, Alt FW.

Nature. 2011 Jan 13;469(7329):250-4. doi: 10.1038/nature09604. Epub 2010 Dec 15.


Tp53 deletion in B lineage cells predisposes mice to lymphomas with oncogenic translocations.

Rowh MA, DeMicco A, Horowitz JE, Yin B, Yang-Iott KS, Fusello AM, Hobeika E, Reth M, Bassing CH.

Oncogene. 2011 Nov 24;30(47):4757-64. doi: 10.1038/onc.2011.191. Epub 2011 May 30.


Role of the translocation partner in protection against AID-dependent chromosomal translocations.

Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):187-92. doi: 10.1073/pnas.0908946107. Epub 2009 Dec 4.


ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.

Zha S, Bassing CH, Sanda T, Brush JW, Patel H, Goff PH, Murphy MM, Tepsuporn S, Gatti RA, Look AT, Alt FW.

J Exp Med. 2010 Jul 5;207(7):1369-80. doi: 10.1084/jem.20100285. Epub 2010 Jun 21.


Functional overlaps between XLF and the ATM-dependent DNA double strand break response.

Kumar V, Alt FW, Oksenych V.

DNA Repair (Amst). 2014 Apr;16:11-22. doi: 10.1016/j.dnarep.2014.01.010. Epub 2014 Feb 20. Review.


Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia.

Ehrlich LA, Yang-Iott K, Bassing CH.

Cell Cycle. 2014;13(19):3076-82. doi: 10.4161/15384101.2014.949144.


IgH class switching and translocations use a robust non-classical end-joining pathway.

Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW.

Nature. 2007 Sep 27;449(7161):478-82. Epub 2007 Aug 22.


Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification.

Difilippantonio MJ, Petersen S, Chen HT, Johnson R, Jasin M, Kanaar R, Ried T, Nussenzweig A.

J Exp Med. 2002 Aug 19;196(4):469-80.


RAG-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.

Petiniot LK, Weaver Z, Vacchio M, Shen R, Wangsa D, Barlow C, Eckhaus M, Steinberg SM, Wynshaw-Boris A, Ried T, Hodes RJ.

Mol Cell Biol. 2002 May;22(9):3174-7.


Redundant and nonredundant functions of ATM and H2AX in αβ T-lineage lymphocytes.

Yin B, Lee BS, Yang-Iott KS, Sleckman BP, Bassing CH.

J Immunol. 2012 Aug 1;189(3):1372-9. doi: 10.4049/jimmunol.1200829. Epub 2012 Jun 22.


Recombinase-activating gene (RAG) 2-mediated V(D)J recombination is not essential for tumorigenesis in Atm-deficient mice.

Petiniot LK, Weaver Z, Barlow C, Shen R, Eckhaus M, Steinberg SM, Ried T, Wynshaw-Boris A, Hodes RJ.

Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6664-9.


Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.

Rooney S, Alt FW, Sekiguchi J, Manis JP.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2471-5. Epub 2005 Feb 7.


ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo.

Dujka ME, Puebla-Osorio N, Tavana O, Sang M, Zhu C.

Oncogene. 2010 Feb 18;29(7):957-65. doi: 10.1038/onc.2009.394. Epub 2009 Nov 16.


AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations.

Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC.

Mol Cell. 2009 Nov 25;36(4):631-41. doi: 10.1016/j.molcel.2009.11.007.


Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase.

Vanasse GJ, Halbrook J, Thomas S, Burgess A, Hoekstra MF, Disteche CM, Willerford DM.

J Clin Invest. 1999 Jun;103(12):1669-75.

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