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Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding.

Sun Y, Atas E, Lindqvist LM, Sonenberg N, Pelletier J, Meller A.

Structure. 2014 Jul 8;22(7):941-8. doi: 10.1016/j.str.2014.04.014. Epub 2014 Jun 5.


The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase.

Sun Y, Atas E, Lindqvist L, Sonenberg N, Pelletier J, Meller A.

Nucleic Acids Res. 2012 Jul;40(13):6199-207. doi: 10.1093/nar/gks278. Epub 2012 Mar 28.


Interactions between eIF4AI and its accessory factors eIF4B and eIF4H.

Rozovsky N, Butterworth AC, Moore MJ.

RNA. 2008 Oct;14(10):2136-48. doi: 10.1261/rna.1049608. Epub 2008 Aug 21.


The DEAD-box helicase eIF4A: paradigm or the odd one out?

Andreou AZ, Klostermeier D.

RNA Biol. 2013 Jan;10(1):19-32. doi: 10.4161/rna.21966. Epub 2012 Sep 20. Review.


A gating mechanism for Pi release governs the mRNA unwinding by eIF4AI during translation initiation.

Lu J, Jiang C, Li X, Jiang L, Li Z, Schneider-Poetsch T, Liu J, Yu K, Liu JO, Jiang H, Luo C, Dang Y.

Nucleic Acids Res. 2015 Dec 2;43(21):10157-67. doi: 10.1093/nar/gkv1033. Epub 2015 Oct 12.


Duplex unwinding and ATPase activities of the DEAD-box helicase eIF4A are coupled by eIF4G and eIF4B.

Özeş AR, Feoktistova K, Avanzino BC, Fraser CS.

J Mol Biol. 2011 Sep 30;412(4):674-87. doi: 10.1016/j.jmb.2011.08.004. Epub 2011 Aug 5.


Investigation of the conserved glutamate immediately following the DEAD box in eukaryotic translation initiation factor 4AI.

Patel K, Shah GK, Kommaraju SS, Low WK.

Biochem Cell Biol. 2014 Feb;92(1):33-42. doi: 10.1139/bcb-2013-0076. Epub 2013 Dec 4.


Molecular dynamics simulation of the allosteric regulation of eIF4A protein from the open to closed state, induced by ATP and RNA substrates.

Meng H, Li C, Wang Y, Chen G.

PLoS One. 2014 Jan 23;9(1):e86104. doi: 10.1371/journal.pone.0086104. eCollection 2014.


eIF4B and eIF4G jointly stimulate eIF4A ATPase and unwinding activities by modulation of the eIF4A conformational cycle.

Andreou AZ, Klostermeier D.

J Mol Biol. 2014 Jan 9;426(1):51-61. doi: 10.1016/j.jmb.2013.09.027. Epub 2013 Sep 27.


Fluorescence methods in the investigation of the DEAD-box helicase mechanism.

Andreou AZ, Klostermeier D.

EXS. 2014;105:161-92. doi: 10.1007/978-3-0348-0856-9_8. Review.


eIF4B, eIF4G and RNA regulate eIF4A activity in translation initiation by modulating the eIF4A conformational cycle.

Harms U, Andreou AZ, Gubaev A, Klostermeier D.

Nucleic Acids Res. 2014 Jul;42(12):7911-22. doi: 10.1093/nar/gku440. Epub 2014 May 21.


DEAD box unwinding caught in the act.

Avanzino BC, Fraser CS.

Structure. 2014 Jul 8;22(7):931-2. doi: 10.1016/j.str.2014.06.005.


RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis.

Oguro A, Ohtsu T, Svitkin YV, Sonenberg N, Nakamura Y.

RNA. 2003 Apr;9(4):394-407.


eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism.

Hilbert M, Kebbel F, Gubaev A, Klostermeier D.

Nucleic Acids Res. 2011 Mar;39(6):2260-70. doi: 10.1093/nar/gkq1127. Epub 2010 Nov 9.


Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.

Bordeleau ME, Mori A, Oberer M, Lindqvist L, Chard LS, Higa T, Belsham GJ, Wagner G, Tanaka J, Pelletier J.

Nat Chem Biol. 2006 Apr;2(4):213-20. Epub 2006 Mar 12.


Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F.

Rogers GW Jr, Richter NJ, Lima WF, Merrick WC.

J Biol Chem. 2001 Aug 17;276(33):30914-22. Epub 2001 Jun 19.


Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation.

Marintchev A, Edmonds KA, Marintcheva B, Hendrickson E, Oberer M, Suzuki C, Herdy B, Sonenberg N, Wagner G.

Cell. 2009 Feb 6;136(3):447-60. doi: 10.1016/j.cell.2009.01.014.


Unwinding single RNA molecules using helicases involved in eukaryotic translation initiation.

Marsden S, Nardelli M, Linder P, McCarthy JE.

J Mol Biol. 2006 Aug 11;361(2):327-35. Epub 2006 Jun 27.


Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A.

Rogers GW Jr, Richter NJ, Merrick WC.

J Biol Chem. 1999 Apr 30;274(18):12236-44.


Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor.

Iwasaki S, Floor SN, Ingolia NT.

Nature. 2016 Jun 23;534(7608):558-61. doi: 10.1038/nature17978. Epub 2016 Jun 15.

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