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Structure-Activity Relationship of Semicarbazone EGA Furnishes Photoaffinity Inhibitors of Anthrax Toxin Cellular Entry.

Jung ME, Chamberlain BT, Ho CL, Gillespie EJ, Bradley KA.

ACS Med Chem Lett. 2014 Jan 21;5(4):363-7. doi: 10.1021/ml400486k. eCollection 2014 Apr 10.


Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.

Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12. doi: 10.1073/pnas.1302334110. Epub 2013 Nov 4.


EGA Protects Mammalian Cells from Clostridium difficile CDT, Clostridium perfringens Iota Toxin and Clostridium botulinum C2 Toxin.

Schnell L, Mittler AK, Sadi M, Popoff MR, Schwan C, Aktories K, Mattarei A, Azarnia Tehran D, Montecucco C, Barth H.

Toxins (Basel). 2016 Apr 1;8(4):101. doi: 10.3390/toxins8040101.


Enzyme occupancy measurement of intracellular protein tyrosine phosphatase 1B using photoaffinity probes.

Skorey K, Waddleton D, Therien M, Leriche T.

Anal Biochem. 2006 Feb 1;349(1):49-61. Epub 2005 Dec 1.


Photoaffinity labeling of the catalytic site of prenyltransferase.

Brems DN, Rilling HC.

Biochemistry. 1979 Mar 6;18(5):860-4.


Quantitative Determination of Lethal Toxin Proteins in Culture Supernatant of Human Live Anthrax Vaccine Bacillus anthracis A16R.

Zai X, Zhang J, Liu J, Liu J, Li L, Yin Y, Fu L, Xu J, Chen W.

Toxins (Basel). 2016 Feb 25;8(3). pii: E56. doi: 10.3390/toxins8030056.


Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design.

Karginov VA, Nestorovich EM, Moayeri M, Leppla SH, Bezrukov SM.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15075-80. Epub 2005 Oct 7.


Photoaffinity labeling of the Ah receptor.

Poland A, Glover E, Ebetino FH, Kende AS.

J Biol Chem. 1986 May 15;261(14):6352-65.


Targeted silencing of anthrax toxin receptors protects against anthrax toxins.

Arévalo MT, Navarro A, Arico CD, Li J, Alkhatib O, Chen S, Diaz-Arévalo D, Zeng M.

J Biol Chem. 2014 May 30;289(22):15730-8. doi: 10.1074/jbc.M113.538587. Epub 2014 Apr 17.


Amiodarone and bepridil inhibit anthrax toxin entry into host cells.

Sanchez AM, Thomas D, Gillespie EJ, Damoiseaux R, Rogers J, Saxe JP, Huang J, Manchester M, Bradley KA.

Antimicrob Agents Chemother. 2007 Jul;51(7):2403-11. Epub 2007 May 7.


Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.

Zhang X, Amin EA.

J Mol Graph Model. 2016 Jan;63:22-8. doi: 10.1016/j.jmgm.2015.11.008. Epub 2015 Nov 17.


Anthrax lethal toxin blocks MAPK kinase-dependent IL-2 production in CD4+ T cells.

Fang H, Cordoba-Rodriguez R, Lankford CS, Frucht DM.

J Immunol. 2005 Apr 15;174(8):4966-71.


Constitutive MEK1 activation rescues anthrax lethal toxin-induced vascular effects in vivo.

Bolcome RE 3rd, Chan J.

Infect Immun. 2010 Dec;78(12):5043-53. doi: 10.1128/IAI.00604-10. Epub 2010 Sep 20.


Bacillus anthracis' lethal toxin induces broad transcriptional responses in human peripheral monocytes.

Chauncey KM, Lopez MC, Sidhu G, Szarowicz SE, Baker HV, Quinn C, Southwick FS.

BMC Immunol. 2012 Jul 2;13:33. doi: 10.1186/1471-2172-13-33.


Photoaffinity labeling adenosine A1 receptors with an antagonist 125I-labeled aryl azide derivative of 8-phenylxanthine.

Earl CQ, Patel A, Craig RH, Daluge SM, Linden J.

J Med Chem. 1988 Apr;31(4):752-6.


New insights into the functions of anthrax toxin.

Banks DJ, Ward SC, Bradley KA.

Expert Rev Mol Med. 2006 Apr 11;8(7):1-18. Review.


Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection.

Moayeri M, Crown D, Jiao GS, Kim S, Johnson A, Leysath C, Leppla SH.

Antimicrob Agents Chemother. 2013 Sep;57(9):4139-45. doi: 10.1128/AAC.00941-13. Epub 2013 Jun 17.

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