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Items: 1 to 20 of 108

1.

Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.

Meredith EL, Ksander G, Monovich LG, Papillon JP, Liu Q, Miranda K, Morris P, Rao C, Burgis R, Capparelli M, Hu QY, Singh A, Rigel DF, Jeng AY, Beil M, Fu F, Hu CW, LaSala D.

ACS Med Chem Lett. 2013 Oct 17;4(12):1203-7. doi: 10.1021/ml400324c. eCollection 2013 Dec 12.

3.

The discovery of potent inhibitors of aldosterone synthase that exhibit selectivity over 11-beta-hydroxylase.

Adams CM, Hu CW, Jeng AY, Karki R, Ksander G, Lasala D, Leung-Chu J, Liang G, Liu Q, Meredith E, Rao C, Rigel DF, Shi J, Smith S, Springer C, Zhang C.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4324-7. doi: 10.1016/j.bmcl.2010.06.086. Epub 2010 Jun 19.

PMID:
20615692
4.

Coexpression of CYP11B2 or CYP11B1 with adrenodoxin and adrenodoxin reductase for assessing the potency and selectivity of aldosterone synthase inhibitors.

LaSala D, Shibanaka Y, Jeng AY.

Anal Biochem. 2009 Nov 1;394(1):56-61. doi: 10.1016/j.ab.2009.07.025. Epub 2009 Jul 19.

PMID:
19622340
5.

Structure-Activity Relationships, Pharmacokinetics, and in Vivo Activity of CYP11B2 and CYP11B1 Inhibitors.

Papillon JP, Adams CM, Hu QY, Lou C, Singh AK, Zhang C, Carvalho J, Rajan S, Amaral A, Beil ME, Fu F, Gangl E, Hu CW, Jeng AY, LaSala D, Liang G, Logman M, Maniara WM, Rigel DF, Smith SA, Ksander GM.

J Med Chem. 2015 Jun 11;58(11):4749-70. doi: 10.1021/acs.jmedchem.5b00407. Epub 2015 May 21.

PMID:
25953419
6.

First Selective CYP11B1 Inhibitors for the Treatment of Cortisol-Dependent Diseases.

Hille UE, Zimmer C, Vock CA, Hartmann RW.

ACS Med Chem Lett. 2010 Oct 22;2(1):2-6. doi: 10.1021/ml100071j. eCollection 2011 Jan 13.

7.

Disorders of the aldosterone synthase and steroid 11beta-hydroxylase deficiencies.

Peter M, Dubuis JM, Sippell WG.

Horm Res. 1999;51(5):211-22. Review.

PMID:
10559665
8.

Development of CYP11B1 and CYP11B2 assays utilizing homogenates of adrenal glands: Utility of monkey as a surrogate for human.

Cerny MA, Csengery A, Schmenk J, Frederick K.

J Steroid Biochem Mol Biol. 2015 Nov;154:197-205. doi: 10.1016/j.jsbmb.2015.08.004. Epub 2015 Aug 21.

PMID:
26303746
9.

In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.

Enberg U, Farnebo LO, Wedell A, Gröndal S, Thorén M, Grimelius L, Kjellman M, Bäckdahl M, Hamberger B.

World J Surg. 2001 Jul;25(7):957-66.

PMID:
11572038
10.

Effect of variation in CYP11B1 and CYP11B2 on corticosteroid phenotype and hypothalamic-pituitary-adrenal axis activity in hypertensive and normotensive subjects.

Freel EM, Ingram M, Wallace AM, White A, Fraser R, Davies E, Connell JM.

Clin Endocrinol (Oxf). 2008 May;68(5):700-6. Epub 2007 Nov 2.

PMID:
17980006
11.
12.

Development of a test system for inhibitors of human aldosterone synthase (CYP11B2): screening in fission yeast and evaluation of selectivity in V79 cells.

Ehmer PB, Bureik M, Bernhardt R, Müller U, Hartmann RW.

J Steroid Biochem Mol Biol. 2002 Jun;81(2):173-9.

PMID:
12137808
13.

Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase.

Ulmschneider S, Müller-Vieira U, Mitrenga M, Hartmann RW, Oberwinkler-Marchais S, Klein CD, Bureik M, Bernhardt R, Antes I, Lengauer T.

J Med Chem. 2005 Mar 24;48(6):1796-805.

PMID:
15771425
14.

The potential of targeting CYP11B.

Bernhardt R.

Expert Opin Ther Targets. 2016 Aug;20(8):923-34. doi: 10.1517/14728222.2016.1151873. Epub 2016 Mar 2. Review.

PMID:
26854589
15.

MicroRNA-24 is a novel regulator of aldosterone and cortisol production in the human adrenal cortex.

Robertson S, MacKenzie SM, Alvarez-Madrazo S, Diver LA, Lin J, Stewart PM, Fraser R, Connell JM, Davies E.

Hypertension. 2013 Sep;62(3):572-8. doi: 10.1161/HYPERTENSIONAHA.113.01102. Epub 2013 Jul 8.

16.

Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor.

Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue K, Okayama S, Takeda Y, Kawata H, Horii M, Nakajima T, Uemura S, Mochizuki N, Saito Y.

Endocrinology. 2009 Jul;150(7):3110-7. doi: 10.1210/en.2008-1624. Epub 2009 Apr 2.

17.

Adrenocortical zonation in humans under normal and pathological conditions.

Nishimoto K, Nakagawa K, Li D, Kosaka T, Oya M, Mikami S, Shibata H, Itoh H, Mitani F, Yamazaki T, Ogishima T, Suematsu M, Mukai K.

J Clin Endocrinol Metab. 2010 May;95(5):2296-305. doi: 10.1210/jc.2009-2010. Epub 2010 Mar 3.

PMID:
20200334
18.

Steroid 11-beta-hydroxylase deficiency caused by compound heterozygosity for a novel mutation, p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele.

Kuribayashi I, Nomoto S, Massa G, Oostdijk W, Wit JM, Wolffenbuttel BH, Shizuta Y, Honke K.

Horm Res. 2005;63(6):284-93. Epub 2005 Jul 15.

PMID:
16024935
19.

Association between aldosterone production and variation in the 11beta-hydroxylase (CYP11B1) gene.

Imrie H, Freel M, Mayosi BM, Davies E, Fraser R, Ingram M, Cordell HJ, Farrall M, Avery PJ, Watkins H, Keavney B, Connell JM.

J Clin Endocrinol Metab. 2006 Dec;91(12):5051-6. Epub 2006 Sep 19.

PMID:
16984984
20.

Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas.

Fallo F, Pezzi V, Barzon L, Mulatero P, Veglio F, Sonino N, Mathis JM.

Eur J Endocrinol. 2002 Dec;147(6):795-802.

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