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Items: 1 to 20 of 63

1.

DNA Sequence Preference and Adduct Orientation of Pyrrolo[2,1-c][1,4]benzodiazepine Antitumor Agents.

Rahman KM, Vassoler H, James CH, Thurston DE.

ACS Med Chem Lett. 2010 Aug 13;1(8):427-32. doi: 10.1021/ml100131b. eCollection 2010 Nov 11.

2.

Effect of hairpin loop structure on reactivity, sequence preference and adduct orientation of a DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour agent.

Thurston DE, Vassoler H, Jackson PJ, James CH, Rahman KM.

Org Biomol Chem. 2015 Apr 7;13(13):4031-40. doi: 10.1039/c4ob02405b.

PMID:
25733051
3.

Covalent Bonding of Pyrrolobenzodiazepines (PBDs) to Terminal Guanine Residues within Duplex and Hairpin DNA Fragments.

Mantaj J, Jackson PJ, Karu K, Rahman KM, Thurston DE.

PLoS One. 2016 Apr 7;11(4):e0152303. doi: 10.1371/journal.pone.0152303. eCollection 2016.

4.

Observation of the reversibility of a covalent pyrrolobenzodiazepine (PBD) DNA adduct by HPLC/MS and CD spectroscopy.

Rahman KM, James CH, Thurston DE.

Org Biomol Chem. 2011 Mar 7;9(5):1632-41. doi: 10.1039/c0ob00762e. Epub 2011 Jan 21.

PMID:
21253653
5.

Solution structure of a 2:1 C2-(2-naphthyl) pyrrolo[2,1-c][1,4]benzodiazepine DNA adduct: molecular basis for unexpectedly high DNA helix stabilization.

Antonow D, Barata T, Jenkins TC, Parkinson GN, Howard PW, Thurston DE, Zloh M.

Biochemistry. 2008 Nov 11;47(45):11818-29. doi: 10.1021/bi801225q. Epub 2008 Oct 17.

PMID:
18925745
6.
7.

Effect of base sequence on the DNA cross-linking properties of pyrrolobenzodiazepine (PBD) dimers.

Rahman KM, James CH, Thurston DE.

Nucleic Acids Res. 2011 Jul;39(13):5800-12. doi: 10.1093/nar/gkr122. Epub 2011 Mar 21.

8.

Solution structure of the (+)-cis-anti-benzo[a]pyrene-dA ([BP]dA) adduct opposite dT in a DNA duplex.

Mao B, Gu Z, Gorin A, Chen J, Hingerty BE, Amin S, Broyde S, Geacintov NE, Patel DJ.

Biochemistry. 1999 Aug 17;38(33):10831-42.

PMID:
10451380
9.

Determination of the structural role of the linking moieties in the DNA binding of adozelesin.

Cameron L, Thompson AS.

Biochemistry. 2000 May 2;39(17):5004-12.

PMID:
10819964
11.

Observation of a single-stranded DNA/pyrrolobenzodiazepine adduct.

Rahman KM, James CH, Bui TT, Drake AF, Thurston DE.

J Am Chem Soc. 2011 Dec 7;133(48):19376-85. doi: 10.1021/ja205395r. Epub 2011 Nov 9.

PMID:
21928841
12.

Inter- and intrastrand DNA crosslinks by 2-fluoro-substituted pyrrolobenzodiazepine dimers: stability, stereochemistry and drug orientation.

Seifert J, Pezeshki S, Kamal A, Weisz K.

Org Biomol Chem. 2012 Sep 14;10(34):6850-60. doi: 10.1039/c2ob25654a. Epub 2012 Jul 26.

PMID:
22837138
13.

Solution structure of a covalently bound pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex.

Rettig M, Weingarth M, Langel W, Kamal A, Kumar PP, Weisz K.

Biochemistry. 2009 Dec 29;48(51):12223-32. doi: 10.1021/bi901655t.

PMID:
19911838
14.

Nuclear magnetic resonance solution structures of inter- and intrastrand adducts of DNA cross-linker SJG-136.

Hopton SR, Thompson AS.

Biochemistry. 2011 May 31;50(21):4720-32. doi: 10.1021/bi102017e. Epub 2011 May 3.

PMID:
21488658
15.

Pyrrolo[2,1-c][1,4]benzodiazepine as a scaffold for the design and synthesis of anti-tumour drugs.

Cipolla L, Ara├║jo AC, Airoldi C, Bini D.

Anticancer Agents Med Chem. 2009 Jan;9(1):1-31. Review.

PMID:
19149479
16.

Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: a link to tumorigenic activity.

Lin CH, Huang X, Kolbanovskii A, Hingerty BE, Amin S, Broyde S, Geacintov NE, Patel DJ.

J Mol Biol. 2001 Mar 9;306(5):1059-80.

PMID:
11237618
17.

Synthesis and evaluation of a triplex-forming oligonucleotide-pyrrolobenzodiazepine conjugate.

Zhilina ZV, Ziemba AJ, Trent JO, Reed MW, Gorn V, Zhou Q, Duan W, Hurley L, Ebbinghaus SW.

Bioconjug Chem. 2004 Nov-Dec;15(6):1182-92.

PMID:
15546183
18.

A molecular mechanics and dynamics study of the minor adduct between DNA and the carcinogen 2-(acetylamino)fluorene (dG-N2-AAF).

Grad R, Shapiro R, Hingerty BE, Broyde S.

Chem Res Toxicol. 1997 Oct;10(10):1123-32.

PMID:
9348435
19.

Pyrrolobenzodiazepines (PBDs) do not bind to DNA G-quadruplexes.

Rahman KM, Corcoran DB, Bui TT, Jackson PJ, Thurston DE.

PLoS One. 2014 Aug 18;9(8):e105021. doi: 10.1371/journal.pone.0105021. eCollection 2014.

20.

Solution structure of an O6-[4-oxo-4-(3-pyridyl)butyl]guanine adduct in an 11 mer DNA duplex: evidence for formation of a base triplex.

Peterson LA, Vu C, Hingerty BE, Broyde S, Cosman M.

Biochemistry. 2003 Nov 18;42(45):13134-44.

PMID:
14609323

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