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Items: 1 to 20 of 112

1.

Epac1-dependent phospholamban phosphorylation mediates the cardiac response to stresses.

Okumura S, Fujita T, Cai W, Jin M, Namekata I, Mototani Y, Jin H, Ohnuki Y, Tsuneoka Y, Kurotani R, Suita K, Kawakami Y, Hamaguchi S, Abe T, Kiyonari H, Tsunematsu T, Bai Y, Suzuki S, Hidaka Y, Umemura M, Ichikawa Y, Yokoyama U, Sato M, Ishikawa F, Izumi-Nakaseko H, Adachi-Akahane S, Tanaka H, Ishikawa Y.

J Clin Invest. 2014 Jun;124(6):2785-801. doi: 10.1172/JCI64784. Epub 2014 Apr 24.

2.

Novel Epac fluorescent ligand reveals distinct Epac1 vs. Epac2 distribution and function in cardiomyocytes.

Pereira L, Rehmann H, Lao DH, Erickson JR, Bossuyt J, Chen J, Bers DM.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):3991-6. doi: 10.1073/pnas.1416163112. Epub 2015 Mar 17.

3.

Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.

Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DM.

Circulation. 2013 Feb 26;127(8):913-22. doi: 10.1161/CIRCULATIONAHA.12.148619. Epub 2013 Jan 30.

4.

PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways.

Kwak HJ, Park KM, Choi HE, Chung KS, Lim HJ, Park HY.

Cell Signal. 2008 May;20(5):803-14. doi: 10.1016/j.cellsig.2007.12.011. Epub 2007 Dec 28.

PMID:
18276108
5.

Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation.

Gramolini AO, Trivieri MG, Oudit GY, Kislinger T, Li W, Patel MM, Emili A, Kranias EG, Backx PH, Maclennan DH.

Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2446-51. Epub 2006 Feb 6.

6.

Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.

Laurent AC, Bisserier M, Lucas A, Tortosa F, Roumieux M, De Régibus A, Swiader A, Sainte-Marie Y, Heymes C, Vindis C, Lezoualc'h F.

Cardiovasc Res. 2015 Jan 1;105(1):55-64. doi: 10.1093/cvr/cvu242. Epub 2014 Nov 19.

PMID:
25411381
7.

Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy.

Ulucan C, Wang X, Baljinnyam E, Bai Y, Okumura S, Sato M, Minamisawa S, Hirotani S, Ishikawa Y.

Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1662-72. Epub 2007 Jun 8.

8.

Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.

Najafi A, Sequeira V, Helmes M, Bollen IA, Goebel M, Regan JA, Carrier L, Kuster DW, Van Der Velden J.

Cardiovasc Res. 2016 May 15;110(2):200-14. doi: 10.1093/cvr/cvw026. Epub 2016 Jan 29.

PMID:
26825555
9.

Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy.

Métrich M, Lucas A, Gastineau M, Samuel JL, Heymes C, Morel E, Lezoualc'h F.

Circ Res. 2008 Apr 25;102(8):959-65. doi: 10.1161/CIRCRESAHA.107.164947. Epub 2008 Mar 6.

10.

Rap1-mediated activation of extracellular signal-regulated kinases by cyclic AMP is dependent on the mode of Rap1 activation.

Wang Z, Dillon TJ, Pokala V, Mishra S, Labudda K, Hunter B, Stork PJ.

Mol Cell Biol. 2006 Mar;26(6):2130-45.

11.

Role of cyclic AMP sensor Epac1 in masseter muscle hypertrophy and myosin heavy chain transition induced by β2-adrenoceptor stimulation.

Ohnuki Y, Umeki D, Mototani Y, Jin H, Cai W, Shiozawa K, Suita K, Saeki Y, Fujita T, Ishikawa Y, Okumura S.

J Physiol. 2014 Dec 15;592(24):5461-75. doi: 10.1113/jphysiol.2014.282996. Epub 2014 Oct 24.

12.
13.

Ser16 prevails over Thr17 phospholamban phosphorylation in the beta-adrenergic regulation of cardiac relaxation.

Kuschel M, Karczewski P, Hempel P, Schlegel WP, Krause EG, Bartel S.

Am J Physiol. 1999 May;276(5 Pt 2):H1625-33.

14.

Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein.

Zhu M, Gach AA, Liu G, Xu X, Lim CC, Zhang JX, Mao L, Chuprun K, Koch WJ, Liao R, Koren G, Blaxall BC, Mende U.

Am J Physiol Heart Circ Physiol. 2008 Mar;294(3):H1335-47. doi: 10.1152/ajpheart.00584.2007. Epub 2008 Jan 11.

16.

Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes.

Zhang X, Tallini YN, Chen Z, Gan L, Wei B, Doran R, Miao L, Xin HB, Kotlikoff MI, Ji G.

Cardiovasc Res. 2009 Nov 1;84(2):253-62. doi: 10.1093/cvr/cvp212. Epub 2009 Jul 3.

17.

Role of phospholamban in cyclic GMP mediated signaling in cardiac myocytes.

Zhang Q, Scholz PM, Pilzak A, Su J, Weiss HR.

Cell Physiol Biochem. 2007;20(1-4):157-66.

18.

The cAMP binding protein Epac modulates Ca2+ sparks by a Ca2+/calmodulin kinase signalling pathway in rat cardiac myocytes.

Pereira L, Métrich M, Fernández-Velasco M, Lucas A, Leroy J, Perrier R, Morel E, Fischmeister R, Richard S, Bénitah JP, Lezoualc'h F, Gómez AM.

J Physiol. 2007 Sep 1;583(Pt 2):685-94. Epub 2007 Jun 28.

19.

The cAMP binding protein Epac regulates cardiac myofilament function.

Cazorla O, Lucas A, Poirier F, Lacampagne A, Lezoualc'h F.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14144-9. doi: 10.1073/pnas.0812536106. Epub 2009 Aug 6.

20.

Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+ homeostasis and cardiac contractility.

Ji Y, Zhao W, Li B, Desantiago J, Picht E, Kaetzel MA, Schultz Jel J, Kranias EG, Bers DM, Dedman JR.

Am J Physiol Heart Circ Physiol. 2006 Feb;290(2):H599-606. Epub 2005 Sep 2.

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