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Items: 1 to 20 of 118

1.

Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression.

Nazreen S, Alam MS, Hamid H, Yar MS, Dhulap A, Alam P, Pasha MA, Bano S, Alam MM, Haider S, Kharbanda C, Ali Y, Pillai KK.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3034-42. doi: 10.1016/j.bmcl.2014.05.034. Epub 2014 May 22.

PMID:
24890090
2.

Design, Synthesis, and Biological Evaluation of Thiazolidine-2,4-dione Conjugates as PPAR-γ Agonists.

Nazreen S, Alam MS, Hamid H, Shahar Yar M, Dhulap A, Alam P, Pasha MA, Bano S, Alam MM, Haider S, Kharbanda C, Ali Y, Pillai K.

Arch Pharm (Weinheim). 2015 Jun;348(6):421-32. doi: 10.1002/ardp.201400280. Epub 2015 Apr 21.

PMID:
25900064
3.

Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-γ agonists.

Nazreen S, Alam MS, Hamid H, Yar MS, Shafi S, Dhulap A, Alam P, Pasha MA, Bano S, Alam MM, Haider S, Ali Y, Kharbanda C, Pillai KK.

Eur J Med Chem. 2014 Nov 24;87:175-85. doi: 10.1016/j.ejmech.2014.09.010. Epub 2014 Sep 16.

PMID:
25255433
4.

Synthesis, characterization, biological evaluation and docking of coumarin coupled thiazolidinedione derivatives and its bioisosteres as PPARγ agonists.

Shukla S, Kumar P, Das N, Moorthy NS, Shrivastava SK, Trivedi P, Srivastava RS.

Med Chem. 2012 Sep;8(5):834-45.

PMID:
22741802
5.

Discovery of thiazolidine-2,4-dione/biphenylcarbonitrile hybrid as dual PPAR α/γ modulator with antidiabetic effect: in vitro, in silico and in vivo approaches.

Hidalgo-Figueroa S, Ramírez-Espinosa JJ, Estrada-Soto S, Almanza-Pérez JC, Román-Ramos R, Alarcón-Aguilar FJ, Hernández-Rosado JV, Moreno-Díaz H, Díaz-Coutiño D, Navarrete-Vázquez G.

Chem Biol Drug Des. 2013 Apr;81(4):474-83. doi: 10.1111/cbdd.12102. Epub 2013 Mar 21.

PMID:
23289972
6.

Synthesis, molecular docking and anti-diabetic evaluation of 2,4-thiazolidinedione based amide derivatives.

Naim MJ, Alam MJ, Nawaz F, Naidu VGM, Aaghaz S, Sahu M, Siddiqui N, Alam O.

Bioorg Chem. 2017 Aug;73:24-36. doi: 10.1016/j.bioorg.2017.05.007. Epub 2017 May 6.

PMID:
28582649
7.

Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect.

Kharbanda C, Alam MS, Hamid H, Javed K, Dhulap A, Bano S, Ali Y.

Bioorg Med Chem Lett. 2015 Oct 15;25(20):4601-5. doi: 10.1016/j.bmcl.2015.08.062. Epub 2015 Sep 1.

PMID:
26384286
8.

Potent antidiabetic effects of rivoglitazone, a novel peroxisome proliferator-activated receptor-gamma agonist, in obese diabetic rodent models.

Kanda S, Nakashima R, Takahashi K, Tanaka J, Ogawa J, Ogata T, Yachi M, Araki K, Ohsumi J.

J Pharmacol Sci. 2009 Oct;111(2):155-66. Epub 2009 Oct 6.

9.

Novel benzenesulfonylureas containing thiophenylpyrazoline moiety as potential antidiabetic and anticancer agents.

Kharbanda C, Alam MS, Hamid H, Javed K, Shafi S, Ali Y, Alam P, Pasha MA, Dhulap A, Bano S, Nazreen S, Haider S.

Bioorg Med Chem Lett. 2014 Nov 15;24(22):5298-303. doi: 10.1016/j.bmcl.2014.09.044. Epub 2014 Sep 23.

PMID:
25442322
10.

Novel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists.

Kharbanda C, Alam MS, Hamid H, Javed K, Bano S, Ali Y, Dhulap A, Alam P, Pasha MA.

Chem Biol Drug Des. 2016 Sep;88(3):354-62. doi: 10.1111/cbdd.12760. Epub 2016 May 27.

PMID:
27037532
11.

Synthesis, characterization and biological evaluation of some novel 2,4-thiazolidinediones as potential cytotoxic, antimicrobial and antihyperglycemic agents.

Avupati VR, Yejella RP, Akula A, Guntuku GS, Doddi BR, Vutla VR, Anagani SR, Adimulam LS, Vyricharla AK.

Bioorg Med Chem Lett. 2012 Oct 15;22(20):6442-50. doi: 10.1016/j.bmcl.2012.08.052. Epub 2012 Aug 21.

PMID:
22981328
12.

Design, synthesis, and biological evaluation of a series of alkoxy-3-indolylacetic acids as peroxisome proliferator-activated receptor γ/δ agonists.

Gim HJ, Li H, Jeong JH, Lee SJ, Sung MK, Song MY, Park BH, Oh SJ, Ryu JH, Jeon R.

Bioorg Med Chem. 2015 Jul 1;23(13):3322-36. doi: 10.1016/j.bmc.2015.04.046. Epub 2015 Apr 23.

PMID:
25982078
13.

Identification of putative metabolites of docosahexaenoic acid as potent PPARgamma agonists and antidiabetic agents.

Yamamoto K, Itoh T, Abe D, Shimizu M, Kanda T, Koyama T, Nishikawa M, Tamai T, Ooizumi H, Yamada S.

Bioorg Med Chem Lett. 2005 Feb 1;15(3):517-22.

PMID:
15664804
14.

Docking, synthesis and anti-diabetic activity of novel sulfonylhydrazone derivatives designed as PPAR-gamma agonists.

Zapata-Sudo G, Lima LM, Pereira SL, Trachez MM, da Costa FP, Souza BJ, Monteiro CE, Romeiro NC, D'Andrea ÉD, Sudo RT, Barreiro EJ.

Curr Top Med Chem. 2012;12(19):2037-48.

PMID:
23167793
15.

Balaglitazone: a second generation peroxisome proliferator-activated receptor (PPAR) gamma (γ) agonist.

Agrawal R, Jain P, Dikshit SN.

Mini Rev Med Chem. 2012 Feb;12(2):87-97. Review.

PMID:
22372600
16.

Design, synthesis and in-vivo hypoglycemic evaluation of novel non - TZD'S in a type - 2 diabetic model.

Jadhav R, Gupta-Rajoria R, Pal T, Subramanian RC.

Med Chem. 2013 Feb;9(1):104-11.

PMID:
22762162
17.
18.

5-aryl thiazolidine-2,4-diones: discovery of PPAR dual alpha/gamma agonists as antidiabetic agents.

Desai RC, Han W, Metzger EJ, Bergman JP, Gratale DF, MacNaul KL, Berger JP, Doebber TW, Leung K, Moller DE, Heck JV, Sahoo SP.

Bioorg Med Chem Lett. 2003 Aug 18;13(16):2795-8.

PMID:
12873517
19.

Anti-inflammatory effect of antidiabetic thiazolidinediones prevents bone resorption rather than cartilage changes in experimental polyarthritis.

Koufany M, Moulin D, Bianchi A, Muresan M, Sebillaud S, Netter P, Weryha G, Jouzeau JY.

Arthritis Res Ther. 2008;10(1):R6. doi: 10.1186/ar2354. Epub 2008 Jan 16.

20.

Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities.

da Costa Leite LF, Veras Mourão RH, de Lima Mdo C, Galdino SL, Hernandes MZ, de Assis Rocha Neves F, Vidal S, Barbe J, da Rocha Pitta I.

Eur J Med Chem. 2007 Oct;42(10):1263-71. Epub 2007 Mar 3.

PMID:
17448573

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