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Items: 1 to 20 of 90


Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity.

Kumar S, Žigman M, Patel TR, Trageser B, Gross JC, Rahm K, Boutros M, Gradl D, Steinbeisser H, Holstein T, Stetefeld J, Özbek S.

BMC Biol. 2014 May 30;12:44. doi: 10.1186/1741-7007-12-44.


Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6.

Bourhis E, Tam C, Franke Y, Bazan JF, Ernst J, Hwang J, Costa M, Cochran AG, Hannoush RN.

J Biol Chem. 2010 Mar 19;285(12):9172-9. doi: 10.1074/jbc.M109.092130. Epub 2010 Jan 21.


Inhibition of Wnt/β-catenin signaling by a soluble collagen-derived frizzled domain interacting with Wnt3a and the receptors frizzled 1 and 8.

Hendaoui I, Lavergne E, Lee HS, Hong SH, Kim HZ, Parent C, Heuzé-Vourc'h N, Clément B, Musso O.

PLoS One. 2012;7(1):e30601. doi: 10.1371/journal.pone.0030601. Epub 2012 Jan 27. Erratum in: PLoS One. 2012;7(3). doi:10.1371/annotation/bd37b3ad-c242-4e77-9ef3-8e92d1f105f5.


Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling.

Xavier CP, Melikova M, Chuman Y, Üren A, Baljinnyam B, Rubin JS.

Cell Signal. 2014 Jan;26(1):94-101. doi: 10.1016/j.cellsig.2013.09.016. Epub 2013 Sep 28.


Structural basis of Wnt recognition by Frizzled.

Janda CY, Waghray D, Levin AM, Thomas C, Garcia KC.

Science. 2012 Jul 6;337(6090):59-64. doi: 10.1126/science.1222879. Epub 2012 May 31.


Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.

Dann CE, Hsieh JC, Rattner A, Sharma D, Nathans J, Leahy DJ.

Nature. 2001 Jul 5;412(6842):86-90.


LRP6 dimerization through its LDLR domain is required for robust canonical Wnt pathway activation.

Chen J, Yan H, Ren DN, Yin Y, Li Z, He Q, Wo D, Ho MS, Chen Y, Liu Z, Yang J, Liu S, Zhu W.

Cell Signal. 2014 May;26(5):1068-74. doi: 10.1016/j.cellsig.2013.12.020. Epub 2014 Jan 8.


structural Studies of Wnts and identification of an LRP6 binding site.

Chu ML, Ahn VE, Choi HJ, Daniels DL, Nusse R, Weis WI.

Structure. 2013 Jul 2;21(7):1235-42. doi: 10.1016/j.str.2013.05.006. Epub 2013 Jun 20.


The crystal structure of full-length Sizzled from Xenopus laevis yields insights into Wnt-antagonistic function of secreted Frizzled-related proteins.

Bu Q, Li Z, Zhang J, Xu F, Liu J, Liu H.

J Biol Chem. 2017 Sep 29;292(39):16055-16069. doi: 10.1074/jbc.M117.791756. Epub 2017 Aug 14.


Disulfide bond requirements for active Wnt ligands.

MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X.

J Biol Chem. 2014 Jun 27;289(26):18122-36. doi: 10.1074/jbc.M114.575027. Epub 2014 May 19.


Mutational analysis of Norrin-Frizzled4 recognition.

Smallwood PM, Williams J, Xu Q, Leahy DJ, Nathans J.

J Biol Chem. 2007 Feb 9;282(6):4057-68. Epub 2006 Dec 6.


Dissecting molecular differences between Wnt coreceptors LRP5 and LRP6.

MacDonald BT, Semenov MV, Huang H, He X.

PLoS One. 2011;6(8):e23537. doi: 10.1371/journal.pone.0023537. Epub 2011 Aug 24.


Identification of key residues and regions important for porcupine-mediated Wnt acylation.

Rios-Esteves J, Haugen B, Resh MD.

J Biol Chem. 2014 Jun 13;289(24):17009-19. doi: 10.1074/jbc.M114.561209. Epub 2014 May 5.


Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.

Özhan G, Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P, Weidinger G.

Dev Cell. 2013 Aug 26;26(4):331-45. doi: 10.1016/j.devcel.2013.07.020.


Sequence and structural difference favors a distinct preference of Wnt3a binding with co-receptor LRP6.

Sahu I, Mishra S, Undi R, Kandi R, Gutti U, Gutti RK.

J Biomol Struct Dyn. 2015;33(10):2133-44. doi: 10.1080/07391102.2014.991352. Epub 2015 Jan 6.


WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.

Coombs GS, Yu J, Canning CA, Veltri CA, Covey TM, Cheong JK, Utomo V, Banerjee N, Zhang ZH, Jadulco RC, Concepcion GP, Bugni TS, Harper MK, Mihalek I, Jones CM, Ireland CM, Virshup DM.

J Cell Sci. 2010 Oct 1;123(Pt 19):3357-67. doi: 10.1242/jcs.072132. Epub 2010 Sep 7.


Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization.

DeBruine ZJ, Ke J, Harikumar KG, Gu X, Borowsky P, Williams BO, Xu W, Miller LJ, Xu HE, Melcher K.

Genes Dev. 2017 May 1;31(9):916-926. doi: 10.1101/gad.298331.117. Epub 2017 May 25.


Wnt3-frizzled 1 chimera as a model to study canonical Wnt signaling.

Bhat RA, Stauffer B, Della Pietra A, Bodine PV.

J Cell Biochem. 2010 Apr 1;109(5):876-84. doi: 10.1002/jcb.22447.


LGR5 interacts and cointernalizes with Wnt receptors to modulate Wnt/β-catenin signaling.

Carmon KS, Lin Q, Gong X, Thomas A, Liu Q.

Mol Cell Biol. 2012 Jun;32(11):2054-64. doi: 10.1128/MCB.00272-12. Epub 2012 Apr 2. Erratum in: Mol Cell Biol. 2017 Jun 15;37(13):.


Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.

Boschert V, van Dinther M, Weidauer S, van Pee K, Muth EM, Ten Dijke P, Mueller TD.

PLoS One. 2013 Nov 29;8(11):e81710. doi: 10.1371/journal.pone.0081710. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/067f1197-3290-4d1e-8f77-4d3996a6b9e8.

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