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Items: 1 to 20 of 88

1.

Discovery of structurally simplified analogs of colchicine as an immunosuppressant.

Chang DJ, Kim WJ.

Bioorg Med Chem Lett. 2014 Jul 15;24(14):3121-5. doi: 10.1016/j.bmcl.2014.05.007. Epub 2014 May 14.

PMID:
24881570
2.

Part II. Development of novel colchicine-derived immunosuppressants with improved pharmacokinetic properties.

Chang DJ, Lee S, Jang J, Kim SO, Kim WJ, Suh YG.

Bioorg Med Chem Lett. 2012 Nov 1;22(21):6750-5. doi: 10.1016/j.bmcl.2012.08.068. Epub 2012 Aug 25.

PMID:
23017885
3.

Design, synthesis and identification of novel colchicine-derived immunosuppressant.

Chang DJ, Yoon EY, Lee GB, Kim SO, Kim WJ, Kim YM, Jung JW, An H, Suh YG.

Bioorg Med Chem Lett. 2009 Aug 1;19(15):4416-20. doi: 10.1016/j.bmcl.2009.05.054. Epub 2009 May 18.

PMID:
19502058
4.

Phainanoids A-F, a new class of potent immunosuppressive triterpenoids with an unprecedented carbon skeleton from Phyllanthus hainanensis.

Fan YY, Zhang H, Zhou Y, Liu HB, Tang W, Zhou B, Zuo JP, Yue JM.

J Am Chem Soc. 2015 Jan 14;137(1):138-41. doi: 10.1021/ja511813g. Epub 2014 Dec 24.

PMID:
25522036
5.

Aromatic quinolinecarboxamides as selective, orally active antibody production inhibitors for prevention of acute xenograft rejection.

Papageorgiou C, von Matt A, Joergensen J, Andersen E, Wagner K, Beerli C, Than T, Borer X, Florineth A, Rihs G, Schreier MH, Weckbecker G, Heusser C.

J Med Chem. 2001 Jun 7;44(12):1986-92.

PMID:
11384243
6.

Synthesis and immunosuppressive activity of new artemisinin derivatives. 1. [12(beta or alpha)-Dihydroartemisininoxy]phen(ox)yl aliphatic acids and esters.

Yang ZS, Zhou WL, Sui Y, Wang JX, Wu JM, Zhou Y, Zhang Y, He PL, Han JY, Tang W, Li Y, Zuo JP.

J Med Chem. 2005 Jul 14;48(14):4608-17.

PMID:
15999998
7.

Synthesis and evaluation of disubstituted N1- and N3-imidazolidin-2-ones acting as potential immunosuppressive agents.

Sabourin C, Robert JM, Robert-Piessard S, Carbonnelle D, Lang F.

J Enzyme Inhib Med Chem. 2004 Dec;19(6):459-65.

PMID:
15662949
8.

Discovery of diverse human dihydroorotate dehydrogenase inhibitors as immunosuppressive agents by structure-based virtual screening.

Diao Y, Lu W, Jin H, Zhu J, Han L, Xu M, Gao R, Shen X, Zhao Z, Liu X, Xu Y, Huang J, Li H.

J Med Chem. 2012 Oct 11;55(19):8341-9. doi: 10.1021/jm300630p. Epub 2012 Sep 28.

PMID:
22984987
9.

Synthesis and structure-immunosuppressive activity relationships of bakuchiol and its derivatives.

Chen H, Du X, Tang W, Zhou Y, Zuo J, Feng H, Li Y.

Bioorg Med Chem. 2008 Mar 1;16(5):2403-11. Epub 2007 Nov 28.

PMID:
18063371
10.

Discovery of a new class of immunosuppressants from Trichothecium roseum co-inspired by cross-kingdom similarity in innate immunity and pharmacophore motif.

Zhang AH, Wang XQ, Han WB, Sun Y, Guo Y, Wu Q, Ge HM, Song YC, Ng SW, Xu Q, Tan RX.

Chem Asian J. 2013 Dec;8(12):3101-7. doi: 10.1002/asia.201300734. Epub 2013 Sep 20.

PMID:
24108442
11.

Synergistic effects of Isatis tinctoria L. and tacrolimus in the prevention of acute heart rejection in mice.

Wang Y, Qin Q, Chen J, Kuang X, Xia J, Xie B, Wang F, Liang H, Qi Z.

Transpl Immunol. 2009 Dec;22(1-2):5-11. doi: 10.1016/j.trim.2009.09.004. Epub 2009 Sep 18.

PMID:
19766187
12.

Colchicine-derived compound CT20126 promotes skin allograft survival by regulating the balance of Th1 and Th2 cytokine production.

Lee SJ, Namkoong S, Ha KS, Nam WD, Kwon YG, Lee H, Yoon EY, Chang DJ, Kim SO, Kim YM.

Exp Mol Med. 2007 Apr 30;39(2):230-8.

13.

Separation of tubulin-binding and anti-inflammatory activity in colchicine analogs and congeners.

Sugio K, Maruyama M, Tsurufuji S, Sharma PN, Brossi A.

Life Sci. 1987 Jan 5;40(1):35-9.

PMID:
3796211
14.

Pyrazole bioisosteres of leflunomide as B-cell immunosuppressants for xenotransplantation and chronic rejection: scope and limitations.

Papageorgiou C, Albert R, Floersheim P, Lemaire M, Bitch F, Weber HP, Andersen E, Hungerford V, Schreier MH.

J Med Chem. 1998 Aug 27;41(18):3530-8.

PMID:
9719606
15.

A phenotypic drug discovery study on thienodiazepine derivatives as inhibitors of T cell proliferation induced by CD28 co-stimulation leads to the discovery of a first bromodomain inhibitor.

Endo J, Hikawa H, Hamada M, Ishibuchi S, Fujie N, Sugiyama N, Tanaka M, Kobayashi H, Sugahara K, Oshita K, Iwata K, Ooike S, Murata M, Sumichika H, Chiba K, Adachi K.

Bioorg Med Chem Lett. 2016 Mar 1;26(5):1365-70. doi: 10.1016/j.bmcl.2016.01.084. Epub 2016 Feb 2.

PMID:
26869194
16.

Synthesis and evaluation of a novel series of quinoline derivatives with immunosuppressive activity.

Liu GB, Xu JL, He CC, Chen G, Xu Q, Xu HX, Li JX.

Bioorg Med Chem. 2009 Aug 1;17(15):5433-41. doi: 10.1016/j.bmc.2009.06.043. Epub 2009 Jun 26.

PMID:
19596582
17.

Discovery of 7-N-piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity.

Jang MY, Lin Y, De Jonghe S, Gao LJ, Vanderhoydonck B, Froeyen M, Rozenski J, Herman J, Louat T, Van Belle K, Waer M, Herdewijn P.

J Med Chem. 2011 Jan 27;54(2):655-68. doi: 10.1021/jm101254z. Epub 2010 Dec 20.

PMID:
21171614
18.

Diminutive effect on T and B-cell proliferation of non-cytotoxic α-santonin derived 1,2,3-triazoles: a report.

Chinthakindi PK, Sangwan PL, Farooq S, Aleti RR, Kaul A, Saxena AK, Murthy YL, Vishwakarma RA, Koul S.

Eur J Med Chem. 2013 Feb;60:365-75. doi: 10.1016/j.ejmech.2012.12.018. Epub 2012 Dec 17.

PMID:
23314050
20.

Discovery and synthesis of new immunosuppressive alkaloids from the stem of Fissistigma oldhamii (Hemsl.) Merr.

Zhang YN, Zhong XG, Zheng ZP, Hu XD, Zuo JP, Hu LH.

Bioorg Med Chem. 2007 Jan 15;15(2):988-96. Epub 2006 Oct 19.

PMID:
17081761

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