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Items: 1 to 20 of 103


Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage.

Das K, Martinez SE, Bandwar RP, Arnold E.

Nucleic Acids Res. 2014 Jul;42(12):8125-37. doi: 10.1093/nar/gku487. Epub 2014 May 31.


N348I in HIV-1 reverse transcriptase can counteract the nevirapine-mediated bias toward RNase H cleavage during plus-strand initiation.

Biondi MJ, Beilhartz GL, McCormick S, Götte M.

J Biol Chem. 2010 Aug 27;285(35):26966-75. doi: 10.1074/jbc.M110.105775. Epub 2010 Jun 8.


The N348I mutation at the connection subdomain of HIV-1 reverse transcriptase decreases binding to nevirapine.

Schuckmann MM, Marchand B, Hachiya A, Kodama EN, Kirby KA, Singh K, Sarafianos SG.

J Biol Chem. 2010 Dec 3;285(49):38700-9. doi: 10.1074/jbc.M110.153783. Epub 2010 Sep 27.


HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism.

Das K, Martinez SE, Bauman JD, Arnold E.

Nat Struct Mol Biol. 2012 Jan 22;19(2):253-9. doi: 10.1038/nsmb.2223.


Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication.

Li TK, Barbieri CM, Lin HC, Rabson AB, Yang G, Fan Y, Gaffney BL, Jones RA, Pilch DS.

Biochemistry. 2004 Aug 3;43(30):9732-42.


Molecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutations.

Vijayan RS, Arnold E, Das K.

Proteins. 2014 May;82(5):815-29. doi: 10.1002/prot.24460. Epub 2013 Nov 22.


Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities.

Shaw-Reid CA, Feuston B, Munshi V, Getty K, Krueger J, Hazuda DJ, Parniak MA, Miller MD, Lewis D.

Biochemistry. 2005 Feb 8;44(5):1595-606.


Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid.

Davis WR, Tomsho J, Nikam S, Cook EM, Somand D, Peliska JA.

Biochemistry. 2000 Nov 21;39(46):14279-91.


Crystal structure of an eight-base pair duplex containing the 3'-DNA-RNA-5' junction formed during initiation of minus-strand synthesis of HIV replication.

Mueller U, Maier G, Mochi Onori A, Cellai L, Heumann H, Heinemann U.

Biochemistry. 1998 Sep 1;37(35):12005-11.


Slide into action: dynamic shuttling of HIV reverse transcriptase on nucleic acid substrates.

Liu S, Abbondanzieri EA, Rausch JW, Le Grice SF, Zhuang X.

Science. 2008 Nov 14;322(5904):1092-7. doi: 10.1126/science.1163108.


HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.

Das K, Arnold E.

Curr Opin Virol. 2013 Apr;3(2):119-28. doi: 10.1016/j.coviro.2013.03.014. Epub 2013 Apr 19. Review.


Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase.

Patel PH, Jacobo-Molina A, Ding J, Tantillo C, Clark AD Jr, Raag R, Nanni RG, Hughes SH, Arnold E.

Biochemistry. 1995 Apr 25;34(16):5351-63.


Contacts between reverse transcriptase and the primer strand govern the transition from initiation to elongation of HIV-1 reverse transcription.

Lanchy JM, Keith G, Le Grice SF, Ehresmann B, Ehresmann C, Marquet R.

J Biol Chem. 1998 Sep 18;273(38):24425-32.


Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H.

Palaniappan C, Fuentes GM, Rodríguez-Rodríguez L, Fay PJ, Bambara RA.

J Biol Chem. 1996 Jan 26;271(4):2063-70.


Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site.

Sarafianos SG, Das K, Ding J, Boyer PL, Hughes SH, Arnold E.

Chem Biol. 1999 May;6(5):R137-46. Review.

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