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Items: 1 to 20 of 89

1.

Defining the toxicology of aging.

Sorrentino JA, Sanoff HK, Sharpless NE.

Trends Mol Med. 2014 Jul;20(7):375-84. doi: 10.1016/j.molmed.2014.04.004. Epub 2014 May 28. Review.

2.

Interactions of aging and environmental agents: the gerontological perspective.

Martin GM.

Prog Clin Biol Res. 1987;228:25-80. Review.

PMID:
3554264
3.

Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype.

Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J.

J Biol Chem. 2011 Oct 21;286(42):36396-403. doi: 10.1074/jbc.M111.257071. Epub 2011 Aug 31.

4.

p16INK4a reporter mice reveal age-promoting effects of environmental toxicants.

Sorrentino JA, Krishnamurthy J, Tilley S, Alb JG Jr, Burd CE, Sharpless NE.

J Clin Invest. 2014 Jan;124(1):169-73. doi: 10.1172/JCI70960. Epub 2013 Dec 16.

5.

The yin and yang of the Cdkn2a locus in senescence and aging.

Baker DJ, Jin F, van Deursen JM.

Cell Cycle. 2008 Sep 15;7(18):2795-802. Epub 2008 Sep 28.

6.

Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.

Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM.

Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3.

7.

Effect of cytotoxic chemotherapy on markers of molecular age in patients with breast cancer.

Sanoff HK, Deal AM, Krishnamurthy J, Torrice C, Dillon P, Sorrentino J, Ibrahim JG, Jolly TA, Williams G, Carey LA, Drobish A, Gordon BB, Alston S, Hurria A, Kleinhans K, Rudolph KL, Sharpless NE, Muss HB.

J Natl Cancer Inst. 2014 Apr;106(4):dju057. doi: 10.1093/jnci/dju057. Epub 2014 Mar 28.

8.

Cancer, aging and cellular senescence.

Campisi J.

In Vivo. 2000 Jan-Feb;14(1):183-8. Review.

PMID:
10757076
9.

Senescent cells: a novel therapeutic target for aging and age-related diseases.

Naylor RM, Baker DJ, van Deursen JM.

Clin Pharmacol Ther. 2013 Jan;93(1):105-16. doi: 10.1038/clpt.2012.193. Epub 2012 Dec 5. Review.

10.

Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.

Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NE.

Cell. 2013 Jan 17;152(1-2):340-51. doi: 10.1016/j.cell.2012.12.010.

11.
12.

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence.

Coppé JP, Kauser K, Campisi J, Beauséjour CM.

J Biol Chem. 2006 Oct 6;281(40):29568-74. Epub 2006 Jul 31.

13.

Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype.

Salminen A, Ojala J, Kaarniranta K, Haapasalo A, Hiltunen M, Soininen H.

Eur J Neurosci. 2011 Jul;34(1):3-11. doi: 10.1111/j.1460-9568.2011.07738.x. Epub 2011 Jun 7. Review.

PMID:
21649759
14.

p21Waf1/Cip1 plays a critical role in modulating senescence through changes of DNA methylation.

Zheng QH, Ma LW, Zhu WG, Zhang ZY, Tong TJ.

J Cell Biochem. 2006 Aug 1;98(5):1230-48.

PMID:
16514663
15.

Senescent phenotype achieved in vitro is indistinguishable, with the exception of Bcl-2 content, from that attained during the in vivo aging process.

Königsberg M, López-Diazguerrero NE, Aguilar MC, Ventura JL, Gutiérrez-Ruiz MC, Zentella A.

Cell Biol Int. 2004;28(8-9):641-51.

PMID:
15350599
16.
17.

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

Chinta SJ, Lieu CA, Demaria M, Laberge RM, Campisi J, Andersen JK.

J Intern Med. 2013 May;273(5):429-36. doi: 10.1111/joim.12029. Review.

18.

Modulators of cellular senescence: mechanisms, promises, and challenges from in vitro studies with dietary bioactive compounds.

Malavolta M, Costarelli L, Giacconi R, Piacenza F, Basso A, Pierpaoli E, Marchegiani F, Cardelli M, Provinciali M, Mocchegiani E.

Nutr Res. 2014 Dec;34(12):1017-35. doi: 10.1016/j.nutres.2014.02.006. Epub 2014 Mar 6. Review.

PMID:
25476190
20.

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.

Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL.

J Clin Invest. 2013 Mar;123(3):966-72. doi: 10.1172/JCI64098. Epub 2013 Mar 1. Review.

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