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Items: 1 to 20 of 135

1.

Targeting membrane-bound viral RNA synthesis reveals potent inhibition of diverse coronaviruses including the middle East respiratory syndrome virus.

Lundin A, Dijkman R, Bergström T, Kann N, Adamiak B, Hannoun C, Kindler E, Jónsdóttir HR, Muth D, Kint J, Forlenza M, Müller MA, Drosten C, Thiel V, Trybala E.

PLoS Pathog. 2014 May 29;10(5):e1004166. doi: 10.1371/journal.ppat.1004166. eCollection 2014 May.

2.

Expression and Cleavage of Middle East Respiratory Syndrome Coronavirus nsp3-4 Polyprotein Induce the Formation of Double-Membrane Vesicles That Mimic Those Associated with Coronaviral RNA Replication.

Oudshoorn D, Rijs K, Limpens RWAL, Groen K, Koster AJ, Snijder EJ, Kikkert M, Bárcena M.

MBio. 2017 Nov 21;8(6). pii: e01658-17. doi: 10.1128/mBio.01658-17.

3.

Middle East respiratory syndrome coronavirus infection is inhibited by griffithsin.

Millet JK, Séron K, Labitt RN, Danneels A, Palmer KE, Whittaker GR, Dubuisson J, Belouzard S.

Antiviral Res. 2016 Sep;133:1-8. doi: 10.1016/j.antiviral.2016.07.011. Epub 2016 Jul 15.

PMID:
27424494
4.

Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics.

Smith EC, Blanc H, Surdel MC, Vignuzzi M, Denison MR.

PLoS Pathog. 2013 Aug;9(8):e1003565. doi: 10.1371/journal.ppat.1003565. Epub 2013 Aug 15. Erratum in: PLoS Pathog. 2014 Jul;10(7):e1004342. Surdel, Matthew C [added].

5.
6.

Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture.

de Wilde AH, Jochmans D, Posthuma CC, Zevenhoven-Dobbe JC, van Nieuwkoop S, Bestebroer TM, van den Hoogen BG, Neyts J, Snijder EJ.

Antimicrob Agents Chemother. 2014 Aug;58(8):4875-84. doi: 10.1128/AAC.03011-14. Epub 2014 May 19.

7.

Indomethacin has a potent antiviral activity against SARS coronavirus.

Amici C, Di Caro A, Ciucci A, Chiappa L, Castilletti C, Martella V, Decaro N, Buonavoglia C, Capobianchi MR, Santoro MG.

Antivir Ther. 2006;11(8):1021-30.

PMID:
17302372
8.

Antiviral activity of K22 against members of the Order Nidovirales.

Rappe JCF, de Wilde A, Di H, Müller C, Stalder H, V'kovski P, Snijder E, Brinton MA, Ziebuhr J, Ruggli N, Thiel V.

Virus Res. 2018 Jan 11. pii: S0168-1702(17)30856-0. doi: 10.1016/j.virusres.2018.01.002. [Epub ahead of print]

PMID:
29337162
9.

A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.

de Wilde AH, Wannee KF, Scholte FE, Goeman JJ, Ten Dijke P, Snijder EJ, Kikkert M, van Hemert MJ.

J Virol. 2015 Aug;89(16):8318-33. doi: 10.1128/JVI.01029-15. Epub 2015 Jun 3.

10.

Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential.

Kindler E, Jónsdóttir HR, Muth D, Hamming OJ, Hartmann R, Rodriguez R, Geffers R, Fouchier RA, Drosten C, Müller MA, Dijkman R, Thiel V.

MBio. 2013 Feb 19;4(1):e00611-12. doi: 10.1128/mBio.00611-12.

11.

IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms.

Wrensch F, Winkler M, Pöhlmann S.

Viruses. 2014 Sep 26;6(9):3683-98. doi: 10.3390/v6093683.

12.

Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications.

Beachboard DC, Anderson-Daniels JM, Denison MR.

J Virol. 2015 Feb;89(4):2080-9. doi: 10.1128/JVI.02776-14. Epub 2014 Dec 3.

13.

SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum.

Knoops K, Kikkert M, Worm SH, Zevenhoven-Dobbe JC, van der Meer Y, Koster AJ, Mommaas AM, Snijder EJ.

PLoS Biol. 2008 Sep 16;6(9):e226. doi: 10.1371/journal.pbio.0060226.

14.

Coronaviruses resistant to a 3C-like protease inhibitor are attenuated for replication and pathogenesis, revealing a low genetic barrier but high fitness cost of resistance.

Deng X, StJohn SE, Osswald HL, O'Brien A, Banach BS, Sleeman K, Ghosh AK, Mesecar AD, Baker SC.

J Virol. 2014 Oct;88(20):11886-98. doi: 10.1128/JVI.01528-14. Epub 2014 Aug 6.

15.

Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants.

Zhang W, Bailey-Elkin BA, Knaap RCM, Khare B, Dalebout TJ, Johnson GG, van Kasteren PB, McLeish NJ, Gu J, He W, Kikkert M, Mark BL, Sidhu SS.

PLoS Pathog. 2017 May 18;13(5):e1006372. doi: 10.1371/journal.ppat.1006372. eCollection 2017 May.

16.

Middle east respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response.

Siu KL, Yeung ML, Kok KH, Yuen KS, Kew C, Lui PY, Chan CP, Tse H, Woo PC, Yuen KY, Jin DY.

J Virol. 2014 May;88(9):4866-76. doi: 10.1128/JVI.03649-13. Epub 2014 Feb 12.

17.

Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.

Shirato K, Kawase M, Matsuyama S.

J Virol. 2013 Dec;87(23):12552-61. doi: 10.1128/JVI.01890-13. Epub 2013 Sep 11.

18.

MERS-coronavirus replication induces severe in vitro cytopathology and is strongly inhibited by cyclosporin A or interferon-α treatment.

de Wilde AH, Raj VS, Oudshoorn D, Bestebroer TM, van Nieuwkoop S, Limpens RW, Posthuma CC, van der Meer Y, Bárcena M, Haagmans BL, Snijder EJ, van den Hoogen BG.

J Gen Virol. 2013 Aug;94(Pt 8):1749-60. doi: 10.1099/vir.0.052910-0. Epub 2013 Apr 25.

19.

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein.

Xia S, Liu Q, Wang Q, Sun Z, Su S, Du L, Ying T, Lu L, Jiang S.

Virus Res. 2014 Dec 19;194:200-10. doi: 10.1016/j.virusres.2014.10.007. Epub 2014 Oct 14. Review.

PMID:
25451066
20.

Severe acute respiratory syndrome coronavirus nonstructural proteins 3, 4, and 6 induce double-membrane vesicles.

Angelini MM, Akhlaghpour M, Neuman BW, Buchmeier MJ.

MBio. 2013 Aug 13;4(4). pii: e00524-13. doi: 10.1128/mBio.00524-13.

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