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hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme.

Tang F, Zhang L, Xue G, Hynx D, Wang Y, Cron PD, Hundsrucker C, Hergovich A, Frank S, Hemmings BA, Schmitz-Rohmer D.

Cancer Res. 2014 Jul 15;74(14):3779-89. doi: 10.1158/0008-5472.CAN-13-3430. Epub 2014 May 28.


Downregulation of RND3/RhoE in glioblastoma patients promotes tumorigenesis through augmentation of notch transcriptional complex activity.

Liu B, Lin X, Yang X, Dong H, Yue X, Andrade KC, Guo Z, Yang J, Wu L, Zhu X, Zhang S, Tian D, Wang J, Cai Q, Chen Q, Mao S, Chen Q, Chang J.

Cancer Med. 2015 Sep;4(9):1404-16. doi: 10.1002/cam4.484. Epub 2015 Jun 24.


MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells.

Guo X, Xue H, Guo X, Gao X, Xu S, Yan S, Han X, Li T, Shen J, Li G.

Oncotarget. 2015 Dec 8;6(39):41620-37. doi: 10.18632/oncotarget.5871.


Mst1 regulates glioma cell proliferation via the AKT/mTOR signaling pathway.

Chao Y, Wang Y, Liu X, Ma P, Shi Y, Gao J, Shi Q, Hu J, Yu R, Zhou X.

J Neurooncol. 2015 Jan;121(2):279-88. doi: 10.1007/s11060-014-1654-4. Epub 2014 Nov 6.


Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis.

Qiao M, Wang Y, Xu X, Lu J, Dong Y, Tao W, Stein J, Stein GS, Iglehart JD, Shi Q, Pardee AB.

Mol Cell. 2010 May 28;38(4):512-23. doi: 10.1016/j.molcel.2010.03.017.


Full-length Mst1 exhibits growth promoting function in human hepatocellular carcinoma cells.

Ng YK, Lau WS, Lui VW, Cheng AS, Ng PK, Tsui SK, Cheung YS, Lai PB.

FEBS Lett. 2013 Mar 1;587(5):496-503. doi: 10.1016/j.febslet.2013.01.018. Epub 2013 Jan 21.


Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice.

Choi J, Oh S, Lee D, Oh HJ, Park JY, Lee SB, Lim DS.

PLoS One. 2009 Nov 24;4(11):e8011. doi: 10.1371/journal.pone.0008011.


17AEP-GA, an HSP90 antagonist, is a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.

Miekus K, Kijowski J, Sekuła M, Majka M.

Oncol Rep. 2012 Nov;28(5):1903-9. doi: 10.3892/or.2012.1996. Epub 2012 Aug 27.


Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.

You B, Huang S, Qin Q, Yi B, Yuan Y, Xu Z, Sun J.

PLoS One. 2013;8(3):e58697. doi: 10.1371/journal.pone.0058697. Epub 2013 Mar 20.


MST1 promotes apoptosis through regulating Sirt1-dependent p53 deacetylation.

Yuan F, Xie Q, Wu J, Bai Y, Mao B, Dong Y, Bi W, Ji G, Tao W, Wang Y, Yuan Z.

J Biol Chem. 2011 Mar 4;286(9):6940-5. doi: 10.1074/jbc.M110.182543. Epub 2011 Jan 6.


BNIP3 acts as transcriptional repressor of death receptor-5 expression and prevents TRAIL-induced cell death in gliomas.

Burton TR, Henson ES, Azad MB, Brown M, Eisenstat DD, Gibson SB.

Cell Death Dis. 2013 Apr 11;4:e587. doi: 10.1038/cddis.2013.100.


CD44 attenuates activation of the hippo signaling pathway and is a prime therapeutic target for glioblastoma.

Xu Y, Stamenkovic I, Yu Q.

Cancer Res. 2010 Mar 15;70(6):2455-64. doi: 10.1158/0008-5472.CAN-09-2505. Epub 2010 Mar 2.


Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype.

Jeon HY, Kim JK, Ham SW, Oh SY, Kim J, Park JB, Lee JY, Kim SC, Kim H.

Tumour Biol. 2016 May;37(5):5857-67. doi: 10.1007/s13277-015-4439-2. Epub 2015 Nov 19.


Establishment and characterization of a new human glioblastoma cell line, NYGM.

Nuki Y, Uchinokura S, Miyata S, Fukushima T, Hamasuna R, Nakano S, Wakisaka S, Akiyama Y, Itoh H, Kataoka H.

Hum Cell. 2004 Sep;17(3):145-50.


Glioblastoma tumor initiating cells: therapeutic strategies targeting apoptosis and microRNA pathways.

Liu J, Albrecht AM, Ni X, Yang J, Li M.

Curr Mol Med. 2013 Mar;13(3):352-7. Review.


G-protein coupled receptor kinase (GRK)-5 regulates proliferation of glioblastoma-derived stem cells.

Kaur G, Kim J, Kaur R, Tan I, Bloch O, Sun MZ, Safaee M, Oh MC, Sughrue M, Phillips J, Parsa AT.

J Clin Neurosci. 2013 Jul;20(7):1014-8. doi: 10.1016/j.jocn.2012.10.008. Epub 2013 May 18.


Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation.

Tandle AT, Kramp T, Kil WJ, Halthore A, Gehlhaus K, Shankavaram U, Tofilon PJ, Caplen NJ, Camphausen K.

Eur J Cancer. 2013 Sep;49(14):3020-8. doi: 10.1016/j.ejca.2013.05.013. Epub 2013 Jun 18.


Spy1 induces de-ubiquitinating of RIP1 arrest and confers glioblastoma's resistance to tumor necrosis factor (TNF-α)-induced apoptosis through suppressing the association of CLIPR-59 and CYLD.

Ding Z, Liu Y, Yao L, Wang D, Zhang J, Cui G, Yang X, Huang X, Liu F, Shen A.

Cell Cycle. 2015;14(13):2149-59. doi: 10.1080/15384101.2015.1041688. Epub 2015 May 27.


Inhibition of Notch signaling alters the phenotype of orthotopic tumors formed from glioblastoma multiforme neurosphere cells but does not hamper intracranial tumor growth regardless of endogene Notch pathway signature.

Kristoffersen K, Nedergaard MK, Villingshøj M, Borup R, Broholm H, Kjær A, Poulsen HS, Stockhausen MT.

Cancer Biol Ther. 2014 Jul;15(7):862-77. doi: 10.4161/cbt.28876. Epub 2014 Apr 22.

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