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Items: 1 to 20 of 101

1.

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.

Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, Reed JC.

J Biomol Screen. 2014 Sep;19(8):1201-11. doi: 10.1177/1087057114536227.

2.

High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry.

Curpan RF, Simons PC, Zhai D, Young SM, Carter MB, Bologa CG, Oprea TI, Satterthwait AC, Reed JC, Edwards BS, Sklar LA.

Assay Drug Dev Technol. 2011 Oct;9(5):465-74. doi: 10.1089/adt.2010.0363.

3.

High impact technologies for natural products screening.

Koehn FE.

Prog Drug Res. 2008;65:175, 177-210. Review.

PMID:
18084916
4.

Gambogic acid is an antagonist of antiapoptotic Bcl-2 family proteins.

Zhai D, Jin C, Shiau CW, Kitada S, Satterthwait AC, Reed JC.

Mol Cancer Ther. 2008 Jun;7(6):1639-46. doi: 10.1158/1535-7163.MCT-07-2373.

5.

High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1.

Zhai D, Godoi P, Sergienko E, Dahl R, Chan X, Brown B, Rascon J, Hurder A, Su Y, Chung TD, Jin C, Diaz P, Reed JC.

J Biomol Screen. 2012 Mar;17(3):350-60. doi: 10.1177/1087057111429372.

PMID:
22156224
6.

A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions.

Du Y, Nikolovska-Coleska Z, Qui M, Li L, Lewis I, Dingledine R, Stuckey JA, Krajewski K, Roller PP, Wang S, Fu H.

Assay Drug Dev Technol. 2011 Aug;9(4):382-93. doi: 10.1089/adt.2010.0292.

7.

A new assay for the discovery of Bcl-XL inhibitors.

Pisoni C, Cimoli G, Resconi A, Losi D, Lorenzetti R, Parodi S, Carrano L.

Farmaco. 2005 Nov-Dec;60(11-12):938-43.

PMID:
16054143
8.

A 1536-well fluorescence polarization assay to screen for modulators of the MUSASHI family of RNA-binding proteins.

Minuesa G, Antczak C, Shum D, Radu C, Bhinder B, Li Y, Djaballah H, Kharas MG.

Comb Chem High Throughput Screen. 2014;17(7):596-609.

9.

A time-resolved fluorescence resonance energy transfer assay for high-throughput screening of 14-3-3 protein-protein interaction inhibitors.

Du Y, Fu RW, Lou B, Zhao J, Qui M, Khuri FR, Fu H.

Assay Drug Dev Technol. 2013 Jul;11(6):367-81. doi: 10.1089/adt.2013.507.

10.

Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL.

Wan KF, Wang S, Brown CJ, Yu VC, Entzeroth M, Lane DP, Lee MA.

Cell Cycle. 2009 Dec;8(23):3943-52.

PMID:
19901550
11.

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

Annang F, Pérez-Moreno G, García-Hernández R, Cordon-Obras C, Martín J, Tormo JR, Rodríguez L, de Pedro N, Gómez-Pérez V, Valente M, Reyes F, Genilloud O, Vicente F, Castanys S, Ruiz-Pérez LM, Navarro M, Gamarro F, González-Pacanowska D.

J Biomol Screen. 2015 Jan;20(1):82-91. doi: 10.1177/1087057114555846.

PMID:
25332350
12.

Rediscovering natural products as a source of new drugs.

Koehn FE, Carter GT.

Discov Med. 2005 Apr;5(26):159-64.

13.
14.

High-throughput methods to detect dimerization of Bcl-2 family proteins.

Whitfield J, Harada K, Bardelle C, Staddon JM.

Anal Biochem. 2003 Nov 15;322(2):170-8.

PMID:
14596824
15.
16.

A high-throughput fluorescence polarization assay for inhibitors of gyrase B.

Glaser BT, Malerich JP, Duellman SJ, Fong J, Hutson C, Fine RM, Keblansky B, Tang MJ, Madrid PB.

J Biomol Screen. 2011 Feb;16(2):230-8. doi: 10.1177/1087057110392038.

17.

Discovery of novel inhibitors of Bcl-xL using multiple high-throughput screening platforms.

Qian J, Voorbach MJ, Huth JR, Coen ML, Zhang H, Ng SC, Comess KM, Petros AM, Rosenberg SH, Warrior U, Burns DJ.

Anal Biochem. 2004 May 15;328(2):131-8.

PMID:
15113688
18.

High-throughput fluorescence assay for small-molecule inhibitors of autophagins/Atg4.

Shu CW, Madiraju C, Zhai D, Welsh K, Diaz P, Sergienko E, Sano R, Reed JC.

J Biomol Screen. 2011 Feb;16(2):174-82. doi: 10.1177/1087057110392996.

PMID:
21245471
19.

Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response.

Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, Ron D, Sherman DH, Kaufman RJ.

J Biomol Screen. 2011 Sep;16(8):825-35. doi: 10.1177/1087057111414893.

20.

A high-throughput image-based screen for the identification of Bax/Bak-independent caspase activators against drug-resistant cancer cells.

Seervi M, Sobhan PK, Mathew KA, Joseph J, Pillai PR, Santhoshkumar TR.

Apoptosis. 2014 Jan;19(1):269-84. doi: 10.1007/s10495-013-0921-8.

PMID:
24220853

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