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Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.

Asgari E, Farrar CA, Lynch N, Ali YM, Roscher S, Stover C, Zhou W, Schwaeble WJ, Sacks SH.

FASEB J. 2014 Sep;28(9):3996-4003. doi: 10.1096/fj.13-246306. Epub 2014 May 27.


Targeting of mannan-binding lectin-associated serine protease-2 confers protection from myocardial and gastrointestinal ischemia/reperfusion injury.

Schwaeble WJ, Lynch NJ, Clark JE, Marber M, Samani NJ, Ali YM, Dudler T, Parent B, Lhotta K, Wallis R, Farrar CA, Sacks S, Lee H, Zhang M, Iwaki D, Takahashi M, Fujita T, Tedford CE, Stover CM.

Proc Natl Acad Sci U S A. 2011 May 3;108(18):7523-8. doi: 10.1073/pnas.1101748108. Epub 2011 Apr 18.


Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1.

Orsini F, Chrysanthou E, Dudler T, Cummings WJ, Takahashi M, Fujita T, Demopulos G, De Simoni MG, Schwaeble W.

J Neuroinflammation. 2016 Aug 30;13(1):213. doi: 10.1186/s12974-016-0684-6.


Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway.

Takahashi M, Iwaki D, Kanno K, Ishida Y, Xiong J, Matsushita M, Endo Y, Miura S, Ishii N, Sugamura K, Fujita T.

J Immunol. 2008 May 1;180(9):6132-8.


Role of complement in a murine model of peanut-induced anaphylaxis.

Kodama T, Sekine H, Takahashi M, Iwaki D, Machida T, Kanno K, Ishida Y, Endo Y, Fujita T.

Immunobiology. 2013 Jun;218(6):844-50. doi: 10.1016/j.imbio.2012.10.003. Epub 2012 Oct 17.


C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo.

Ruseva MM, Takahashi M, Fujita T, Pickering MC.

Clin Exp Immunol. 2014 Apr;176(1):84-92. doi: 10.1111/cei.12244.


TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2.

Keizer MP, Pouw RB, Kamp AM, Patiwael S, Marsman G, Hart MH, Zeerleder S, Kuijpers TW, Wouters D.

Eur J Immunol. 2015 Feb;45(2):544-50. doi: 10.1002/eji.201445070. Epub 2014 Nov 27.


Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway.

Wallis R, Dodds AW, Mitchell DA, Sim RB, Reid KB, Schwaeble WJ.

J Biol Chem. 2007 Mar 16;282(11):7844-51. Epub 2007 Jan 3.


The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.

Ali YM, Lynch NJ, Haleem KS, Fujita T, Endo Y, Hansen S, Holmskov U, Takahashi K, Stahl GL, Dudler T, Girija UV, Wallis R, Kadioglu A, Stover CM, Andrew PW, Schwaeble WJ.

PLoS Pathog. 2012;8(7):e1002793. doi: 10.1371/journal.ppat.1002793. Epub 2012 Jul 5.


Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway.

Iwaki D, Kanno K, Takahashi M, Endo Y, Lynch NJ, Schwaeble WJ, Matsushita M, Okabe M, Fujita T.

J Immunol. 2006 Dec 15;177(12):8626-32.


Mannan-binding lectin-associated serine protease (MASP)-1 is crucial for lectin pathway activation in human serum, whereas neither MASP-1 nor MASP-3 is required for alternative pathway function.

Degn SE, Jensen L, Hansen AG, Duman D, Tekin M, Jensenius JC, Thiel S.

J Immunol. 2012 Oct 15;189(8):3957-69. doi: 10.4049/jimmunol.1201736. Epub 2012 Sep 10.


Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

Lin T, Zhou W, Farrar CA, Hargreaves RE, Sheerin NS, Sacks SH.

Am J Pathol. 2006 Apr;168(4):1241-8.


The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway.

Iwaki D, Kanno K, Takahashi M, Endo Y, Matsushita M, Fujita T.

J Immunol. 2011 Oct 1;187(7):3751-8. doi: 10.4049/jimmunol.1100280. Epub 2011 Aug 24.


Polymorphisms in mannan-binding lectin (MBL)-associated serine protease 2 affect stability, binding to MBL, and enzymatic activity.

Thiel S, Kolev M, Degn S, Steffensen R, Hansen AG, Ruseva M, Jensenius JC.

J Immunol. 2009 Mar 1;182(5):2939-47. doi: 10.4049/jimmunol.0802053.


The role of MASP-1/3 in complement activation.

Sekine H, Takahashi M, Iwaki D, Fujita T.

Adv Exp Med Biol. 2013;735:41-53. Review.


Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy.

Endo M, Ohi H, Ohsawa I, Fujita T, Matsushita M, Fujita T.

Nephrol Dial Transplant. 1998 Aug;13(8):1984-90.


Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway.

Møller-Kristensen M, Thiel S, Sjöholm A, Matsushita M, Jensenius JC.

Int Immunol. 2007 Feb;19(2):141-9. Epub 2006 Dec 20.


MASP-2, the C3 convertase generating protease of the MBLectin complement activating pathway.

Vorup-Jensen T, Jensenius JC, Thiel S.

Immunobiology. 1998 Aug;199(2):348-57. Review.


Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D.

Takahashi M, Ishida Y, Iwaki D, Kanno K, Suzuki T, Endo Y, Homma Y, Fujita T.

J Exp Med. 2010 Jan 18;207(1):29-37. doi: 10.1084/jem.20090633. Epub 2009 Dec 28.

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