Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 79


Toxoplasma gondii- derived profilin triggers human toll-like receptor 5-dependent cytokine production.

Salazar Gonzalez RM, Shehata H, O'Connell MJ, Yang Y, Moreno-Fernandez ME, Chougnet CA, Aliberti J.

J Innate Immun. 2014;6(5):685-94. doi: 10.1159/000362367. Epub 2014 May 23.


Structure-based analysis of Toxoplasma gondii profilin: a parasite-specific motif is required for recognition by Toll-like receptor 11.

Kucera K, Koblansky AA, Saunders LP, Frederick KB, De La Cruz EM, Ghosh S, Modis Y.

J Mol Biol. 2010 Nov 5;403(4):616-29. doi: 10.1016/j.jmb.2010.09.022. Epub 2010 Sep 17.


Toxoplasma gondii profilin does not stimulate an innate immune response through bovine or human TLR5.

Tombácz K, Burgess G, Holder A, Werners A, Werling D.

Innate Immun. 2018 Oct;24(7):422-429. doi: 10.1177/1753425918798450. Epub 2018 Sep 8.


Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.

Koblansky AA, Jankovic D, Oh H, Hieny S, Sungnak W, Mathur R, Hayden MS, Akira S, Sher A, Ghosh S.

Immunity. 2013 Jan 24;38(1):119-30. doi: 10.1016/j.immuni.2012.09.016. Epub 2012 Dec 13.


Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.

Raetz M, Kibardin A, Sturge CR, Pifer R, Li H, Burstein E, Ozato K, Larin S, Yarovinsky F.

J Immunol. 2013 Nov 1;191(9):4818-27. doi: 10.4049/jimmunol.1301301. Epub 2013 Sep 27.


Toll-like receptor recognition of Toxoplasma gondii.

Yarovinsky F, Sher A.

Int J Parasitol. 2006 Mar;36(3):255-9. Epub 2006 Jan 13. Review.


The antigen-specific response to Toxoplasma gondii profilin, a TLR11/12 ligand, depends on its intrinsic adjuvant properties.

Hedhli D, Moiré N, Akbar H, Laurent F, Héraut B, Dimier-Poisson I, Mévélec MN.

Med Microbiol Immunol. 2016 Aug;205(4):345-52. doi: 10.1007/s00430-016-0452-3. Epub 2016 Mar 2.


TLR11 activation of dendritic cells by a protozoan profilin-like protein.

Yarovinsky F, Zhang D, Andersen JF, Bannenberg GL, Serhan CN, Hayden MS, Hieny S, Sutterwala FS, Flavell RA, Ghosh S, Sher A.

Science. 2005 Jun 10;308(5728):1626-9. Epub 2005 Apr 28.


Protective immunity against Toxoplasma challenge in mice by coadministration of T. gondii antigens and Eimeria profilin-like protein as an adjuvant.

Hedhli D, Dimier-Poisson I, Judge JW, Rosenberg B, Mévélec MN.

Vaccine. 2009 Apr 6;27(16):2274-81. doi: 10.1016/j.vaccine.2009.01.100. Epub 2009 Jan 31.


Of mice and man: TLR11 (finally) finds profilin.

Lauw FN, Caffrey DR, Golenbock DT.

Trends Immunol. 2005 Oct;26(10):509-11. Review.


Toxoplasma profilin is essential for host cell invasion and TLR11-dependent induction of an interleukin-12 response.

Plattner F, Yarovinsky F, Romero S, Didry D, Carlier MF, Sher A, Soldati-Favre D.

Cell Host Microbe. 2008 Feb 14;3(2):77-87. doi: 10.1016/j.chom.2008.01.001.


Naturally occurring Toll-like receptor 11 (TLR11) and Toll-like receptor 12 (TLR12) polymorphisms are not associated with Toxoplasma gondii infection in wild wood mice.

Morger J, Bajnok J, Boyce K, Craig PS, Rogan MT, Lun ZR, Hide G, Tschirren B.

Infect Genet Evol. 2014 Aug;26:180-4. doi: 10.1016/j.meegid.2014.05.032. Epub 2014 Jun 6.


UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii.

Pifer R, Benson A, Sturge CR, Yarovinsky F.

J Biol Chem. 2011 Feb 4;286(5):3307-14. doi: 10.1074/jbc.M110.171025. Epub 2010 Nov 19.


Toxoplasma gondii profilin promotes recruitment of Ly6Chi CCR2+ inflammatory monocytes that can confer resistance to bacterial infection.

Neal LM, Knoll LJ.

PLoS Pathog. 2014 Jun 12;10(6):e1004203. doi: 10.1371/journal.ppat.1004203. eCollection 2014 Jun.


Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.

Andrade WA, Souza Mdo C, Ramos-Martinez E, Nagpal K, Dutra MS, Melo MB, Bartholomeu DC, Ghosh S, Golenbock DT, Gazzinelli RT.

Cell Host Microbe. 2013 Jan 16;13(1):42-53. doi: 10.1016/j.chom.2012.12.003. Epub 2013 Jan 3.


Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response.

Yarovinsky F, Kanzler H, Hieny S, Coffman RL, Sher A.

Immunity. 2006 Oct;25(4):655-64. Epub 2006 Sep 28.


The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.

Tosh KW, Mittereder L, Bonne-Annee S, Hieny S, Nutman TB, Singer SM, Sher A, Jankovic D.

J Immunol. 2016 Jan 1;196(1):345-56. doi: 10.4049/jimmunol.1501558. Epub 2015 Nov 23.


Toll-like receptor 11-initiated innate immune response in male mouse germ cells.

Chen Q, Zhu W, Liu Z, Yan K, Zhao S, Han D.

Biol Reprod. 2014 Feb 20;90(2):38. doi: 10.1095/biolreprod.113.114421. Print 2014 Feb.


Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.

Hatai H, Lepelley A, Zeng W, Hayden MS, Ghosh S.

PLoS One. 2016 Feb 9;11(2):e0148987. doi: 10.1371/journal.pone.0148987. eCollection 2016.


Human innate immunity to Toxoplasma gondii is mediated by host caspase-1 and ASC and parasite GRA15.

Gov L, Karimzadeh A, Ueno N, Lodoen MB.

MBio. 2013 Jul 9;4(4). pii: e00255-13. doi: 10.1128/mBio.00255-13.

Supplemental Content

Support Center