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Items: 1 to 20 of 86

1.

An enhancer polymorphism at the cardiomyocyte intercalated disc protein NOS1AP locus is a major regulator of the QT interval.

Kapoor A, Sekar RB, Hansen NF, Fox-Talbot K, Morley M, Pihur V, Chatterjee S, Brandimarto J, Moravec CS, Pulit SL; QT Interval-International GWAS Consortium, Pfeufer A, Mullikin J, Ross M, Green ED, Bentley D, Newton-Cheh C, Boerwinkle E, Tomaselli GF, Cappola TP, Arking DE, Halushka MK, Chakravarti A.

Am J Hum Genet. 2014 Jun 5;94(6):854-69. doi: 10.1016/j.ajhg.2014.05.001. Epub 2014 May 22.

2.

Identification of a common variant at the NOS1AP locus strongly associated to QT-interval duration.

Eijgelsheim M, Aarnoudse AL, Rivadeneira F, Kors JA, Witteman JC, Hofman A, van Duijn CM, Uitterlinden AG, Stricker BH.

Hum Mol Genet. 2009 Jan 15;18(2):347-57. doi: 10.1093/hmg/ddn341. Epub 2008 Oct 16.

PMID:
18927126
3.

Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study.

Aarnoudse AJ, Newton-Cheh C, de Bakker PI, Straus SM, Kors JA, Hofman A, Uitterlinden AG, Witteman JC, Stricker BH.

Circulation. 2007 Jul 3;116(1):10-6. Epub 2007 Jun 18.

4.

Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study.

Lehtinen AB, Newton-Cheh C, Ziegler JT, Langefeld CD, Freedman BI, Daniel KR, Herrington DM, Bowden DW.

Diabetes. 2008 Apr;57(4):1108-14. doi: 10.2337/db07-1365. Epub 2008 Jan 30.

5.

Analysis for Genetic Modifiers of Disease Severity in Patients With Long-QT Syndrome Type 2.

Kolder ICRM, Tanck MWT, Postema PG, Barc J, Sinner MF, Zumhagen S, Husemann A, Stallmeyer B, Koopmann TT, Hofman N, Pfeufer A, Lichtner P, Meitinger T, Beckmann BM, Myerburg RJ, Bishopric NH, Roden DM, Kääb S, Wilde AAM, Schott JJ, Schulze-Bahr E, Bezzina CR.

Circ Cardiovasc Genet. 2015 Jun;8(3):447-456. doi: 10.1161/CIRCGENETICS.114.000785. Epub 2015 Mar 3.

6.

Polymorphisms in the NOS1AP gene modulate QT interval duration and risk of arrhythmias in the long QT syndrome.

Tomás M, Napolitano C, De Giuli L, Bloise R, Subirana I, Malovini A, Bellazzi R, Arking DE, Marban E, Chakravarti A, Spooner PM, Priori SG.

J Am Coll Cardiol. 2010 Jun 15;55(24):2745-52. doi: 10.1016/j.jacc.2009.12.065.

7.

Associations between genetic variants in the NOS1AP (CAPON) gene and cardiac repolarization in the old order Amish.

Post W, Shen H, Damcott C, Arking DE, Kao WH, Sack PA, Ryan KA, Chakravarti A, Mitchell BD, Shuldiner AR.

Hum Hered. 2007;64(4):214-9. Epub 2007 Jun 12.

8.

A common variant of NOS1AP is associated with QT interval duration in a Chinese population with Type 2 diabetes.

Lu J, Hu C, Hu W, Zhang R, Wang C, Qin W, Yu W, Xiang K; International Type 2 Diabetes 1q Consortium, Jia W.

Diabet Med. 2010 Sep;27(9):1074-9. doi: 10.1111/j.1464-5491.2010.03072.x.

9.

A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.

Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson MG, Wichmann HE, Marbán E, O'Donnell CJ, Hirschhorn JN, Kääb S, Spooner PM, Meitinger T, Chakravarti A.

Nat Genet. 2006 Jun;38(6):644-51. Epub 2006 Apr 30.

PMID:
16648850
10.

Common variation in NOS1AP and KCNH2 genes and QT interval duration in young adults. The Cardiovascular Risk in Young Finns Study.

Raitakari OT, Blom-Nyholm J, Koskinen TA, Kähönen M, Viikari JS, Lehtimäki T.

Ann Med. 2009;41(2):144-51. doi: 10.1080/07853890802392529.

PMID:
18785031
11.

Multiple independent genetic factors at NOS1AP modulate the QT interval in a multi-ethnic population.

Arking DE, Khera A, Xing C, Kao WH, Post W, Boerwinkle E, Chakravarti A.

PLoS One. 2009;4(1):e4333. doi: 10.1371/journal.pone.0004333. Epub 2009 Jan 30.

12.

Common candidate gene variants are associated with QT interval duration in the general population.

Marjamaa A, Newton-Cheh C, Porthan K, Reunanen A, Lahermo P, Väänänen H, Jula A, Karanko H, Swan H, Toivonen L, Nieminen MS, Viitasalo M, Peltonen L, Oikarinen L, Palotie A, Kontula K, Salomaa V.

J Intern Med. 2009 Apr;265(4):448-58. doi: 10.1111/j.1365-2796.2008.02026.x. Epub 2009 Oct 25.

13.

Genetic variations in nitric oxide synthase 1 adaptor protein are associated with sudden cardiac death in US white community-based populations.

Kao WH, Arking DE, Post W, Rea TD, Sotoodehnia N, Prineas RJ, Bishe B, Doan BQ, Boerwinkle E, Psaty BM, Tomaselli GF, Coresh J, Siscovick DS, Marbán E, Spooner PM, Burke GL, Chakravarti A.

Circulation. 2009 Feb 24;119(7):940-51. doi: 10.1161/CIRCULATIONAHA.108.791723. Epub 2009 Feb 9.

14.

Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA).

Shah SA, Herrington DM, Howard TD, Divers J, Arnett DK, Burke GL, Kao WH, Guo X, Siscovick DS, Chakravarti A, Lima JA, Psaty BM, Tomaselli GF, Rich SS, Bowden DW, Post W.

Ann Noninvasive Electrocardiol. 2013 Jan;18(1):29-40. doi: 10.1111/anec.12028.

15.

Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations.

Tobin MD, Kähönen M, Braund P, Nieminen T, Hajat C, Tomaszewski M, Viik J, Lehtinen R, Ng GA, Macfarlane PW, Burton PR, Lehtimäki T, Samani NJ.

Int J Epidemiol. 2008 Oct;37(5):1132-41. doi: 10.1093/ije/dyn091. Epub 2008 May 29.

PMID:
18511491
16.

Sex is a moderator of the association between NOS1AP sequence variants and QTc in two long QT syndrome founder populations: a pedigree-based measured genotype association analysis.

Winbo A, Stattin EL, Westin IM, Norberg A, Persson J, Jensen SM, Rydberg A.

BMC Med Genet. 2017 Jul 18;18(1):74. doi: 10.1186/s12881-017-0435-2.

17.

Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.

Jamshidi Y, Nolte IM, Dalageorgou C, Zheng D, Johnson T, Bastiaenen R, Ruddy S, Talbott D, Norris KJ, Snieder H, George AL, Marshall V, Shakir S, Kannankeril PJ, Munroe PB, Camm AJ, Jeffery S, Roden DM, Behr ER.

J Am Coll Cardiol. 2012 Aug 28;60(9):841-50. doi: 10.1016/j.jacc.2012.03.031. Epub 2012 Jun 6.

18.

Association of rs10918594 polymorphisms of nitric oxide synthase 1 adaptor protein (NOS1AP) with QTc interval prolongation during kidney transplantation.

Kaczmarczyk M, Biernawska J, Zukowski M, Kotfis K, Zegan-Barańska M, Bińczak-Kuleta A, Ciechanowicz A, Brykczyński M, Bohatyrewicz R.

Transplant Proc. 2011 Oct;43(8):2964-6. doi: 10.1016/j.transproceed.2011.08.035.

PMID:
21996201
19.

Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation.

van Noord C, Aarnoudse AJ, Eijgelsheim M, Sturkenboom MC, Straus SM, Hofman A, Kors JA, Newton-Cheh C, Witteman JC, Stricker BH.

Pharmacogenet Genomics. 2009 Apr;19(4):260-6. doi: 10.1097/FPC.0b013e328324e556.

PMID:
19247217
20.

NOS1AP is a genetic modifier of the long-QT syndrome.

Crotti L, Monti MC, Insolia R, Peljto A, Goosen A, Brink PA, Greenberg DA, Schwartz PJ, George AL Jr.

Circulation. 2009 Oct 27;120(17):1657-63. doi: 10.1161/CIRCULATIONAHA.109.879643. Epub 2009 Oct 12.

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