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Items: 1 to 20 of 106

1.

SHIP1 regulates MSC numbers and their osteolineage commitment by limiting induction of the PI3K/Akt/β-catenin/Id2 axis.

Iyer S, Viernes DR, Chisholm JD, Margulies BS, Kerr WG.

Stem Cells Dev. 2014 Oct 1;23(19):2336-51. doi: 10.1089/scd.2014.0122. Epub 2014 Jul 3.

2.

Role of SHIP1 in bone biology.

Iyer S, Margulies BS, Kerr WG.

Ann N Y Acad Sci. 2013 Mar;1280:11-4. doi: 10.1111/nyas.12091. Review.

3.

SHIP1-expressing mesenchymal stem cells regulate hematopoietic stem cell homeostasis and lineage commitment during aging.

Iyer S, Brooks R, Gumbleton M, Kerr WG.

Stem Cells Dev. 2015 May 1;24(9):1073-81. doi: 10.1089/scd.2014.0501. Epub 2015 Feb 5.

4.

Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi.

Brooks R, Iyer S, Akada H, Neelam S, Russo CM, Chisholm JD, Kerr WG.

Stem Cells. 2015 Mar;33(3):848-58. doi: 10.1002/stem.1902.

5.

Leukemia-associated mutations in SHIP1 inhibit its enzymatic activity, interaction with the GM-CSF receptor and Grb2, and its ability to inactivate PI3K/AKT signaling.

Brauer H, Strauss J, Wegner W, Müller-Tidow C, Horstmann M, Jücker M.

Cell Signal. 2012 Nov;24(11):2095-101. doi: 10.1016/j.cellsig.2012.07.017. Epub 2012 Jul 20.

PMID:
22820502
6.

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MB.

Sci Signal. 2010 May 18;3(122):ra38. doi: 10.1126/scisignal.2000500.

7.
8.

Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.

Rahman P, Huysmans RD, Wiradjaja F, Gurung R, Ooms LM, Sheffield DA, Dyson JM, Layton MJ, Sriratana A, Takada H, Tiganis T, Mitchell CA.

J Biol Chem. 2011 Aug 26;286(34):29758-70. doi: 10.1074/jbc.M111.263103. Epub 2011 Jun 28.

9.

Small-molecule agonists of SHIP1 inhibit the phosphoinositide 3-kinase pathway in hematopoietic cells.

Ong CJ, Ming-Lum A, Nodwell M, Ghanipour A, Yang L, Williams DE, Kim J, Demirjian L, Qasimi P, Ruschmann J, Cao LP, Ma K, Chung SW, Duronio V, Andersen RJ, Krystal G, Mui AL.

Blood. 2007 Sep 15;110(6):1942-9. Epub 2007 May 14.

11.

Therapeutic potential of SH2 domain-containing inositol-5'-phosphatase 1 (SHIP1) and SHIP2 inhibition in cancer.

Fuhler GM, Brooks R, Toms B, Iyer S, Gengo EA, Park MY, Gumbleton M, Viernes DR, Chisholm JD, Kerr WG.

Mol Med. 2012 Feb 10;18:65-75. doi: 10.2119/molmed.2011.00178.

12.

SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27.

Zhou P, Kitaura H, Teitelbaum SL, Krystal G, Ross FP, Takeshita S.

J Immunol. 2006 Dec 15;177(12):8777-84.

13.

Insulin and insulin-like growth factor-1 promote mast cell survival via activation of the phosphatidylinositol-3-kinase pathway.

Lessmann E, Grochowy G, Weingarten L, Giesemann T, Aktories K, Leitges M, Krystal G, Huber M.

Exp Hematol. 2006 Nov;34(11):1532-41.

PMID:
17046573
14.

Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo.

Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Wu J, Ogden N, MacRury T, Szabo C.

Br J Pharmacol. 2013 Mar;168(6):1506-18. doi: 10.1111/bph.12039.

15.

Non-T cell activation linker promotes mast cell survival by dampening the recruitment of SHIP1 by linker for activation of T cells.

Roget K, Malissen M, Malbec O, Malissen B, Daëron M.

J Immunol. 2008 Mar 15;180(6):3689-98.

16.

Regulation of the Src homology 2 domain-containing inositol 5'-phosphatase (SHIP1) by the cyclic AMP-dependent protein kinase.

Zhang J, Walk SF, Ravichandran KS, Garrison JC.

J Biol Chem. 2009 Jul 24;284(30):20070-8. doi: 10.1074/jbc.M109.016865. Epub 2009 Jun 3.

17.

The role of SHIP1 in macrophage programming and activation.

Rauh MJ, Sly LM, Kalesnikoff J, Hughes MR, Cao LP, Lam V, Krystal G.

Biochem Soc Trans. 2004 Nov;32(Pt 5):785-8. Review.

PMID:
15494015
18.

Down-regulation of microRNA-155 attenuates retinal neovascularization via the PI3K/Akt pathway.

Zhuang Z, Xiao-qin, Hu H, Tian SY, Lu ZJ, Zhang TZ, Bai YL.

Mol Vis. 2015 Oct 13;21:1173-84. eCollection 2015.

19.

Regulation of PtdIns(3,4,5)P3/Akt signalling by inositol polyphosphate 5-phosphatases.

Eramo MJ, Mitchell CA.

Biochem Soc Trans. 2016 Feb;44(1):240-52. doi: 10.1042/BST20150214. Review.

PMID:
26862211
20.

Src homology 2 domain-containing inositol 5-phosphatase 1 mediates cell cycle arrest by FcgammaRIIB.

Malbec O, Schmitt C, Bruhns P, Krystal G, Fridman WH, Daëron M.

J Biol Chem. 2001 Aug 10;276(32):30381-91. Epub 2001 May 18.

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