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Items: 1 to 20 of 129

1.

Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complex.

Mnpotra JS, Qiao Z, Cai J, Lynch DL, Grossfield A, Leioatts N, Hurst DP, Pitman MC, Song ZH, Reggio PH.

J Biol Chem. 2014 Jul 18;289(29):20259-72. doi: 10.1074/jbc.M113.539916. Epub 2014 May 22.

2.

Molecular basis of cannabinoid CB1 receptor coupling to the G protein heterotrimer Gαiβγ: identification of key CB1 contacts with the C-terminal helix α5 of Gαi.

Shim JY, Ahn KH, Kendall DA.

J Biol Chem. 2013 Nov 8;288(45):32449-65. doi: 10.1074/jbc.M113.489153. Epub 2013 Oct 3.

3.

The structural basis of the dominant negative phenotype of the Gαi1β1γ2 G203A/A326S heterotrimer.

Liu P, Jia MZ, Zhou XE, De Waal PW, Dickson BM, Liu B, Hou L, Yin YT, Kang YY, Shi Y, Melcher K, Xu HE, Jiang Y.

Acta Pharmacol Sin. 2016 Sep;37(9):1259-72. doi: 10.1038/aps.2016.69. Epub 2016 Aug 8.

4.

The second intracellular loop of the human cannabinoid CB2 receptor governs G protein coupling in coordination with the carboxyl terminal domain.

Zheng C, Chen L, Chen X, He X, Yang J, Shi Y, Zhou N.

PLoS One. 2013 May 7;8(5):e63262. doi: 10.1371/journal.pone.0063262. Print 2013. Erratum in: PLoS One. 2013;8(11). doi:10.1371/annotation/11146424-f236-4fc6-85b2-cd393cfb6a94.

5.

Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations.

Kimura T, Vukoti K, Lynch DL, Hurst DP, Grossfield A, Pitman MC, Reggio PH, Yeliseev AA, Gawrisch K.

Proteins. 2014 Mar;82(3):452-65. doi: 10.1002/prot.24411. Epub 2013 Oct 17.

6.

Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to G(s) and G(i).

Chen XP, Yang W, Fan Y, Luo JS, Hong K, Wang Z, Yan JF, Chen X, Lu JX, Benovic JL, Zhou NM.

Br J Pharmacol. 2010 Dec;161(8):1817-34. doi: 10.1111/j.1476-5381.2010.01006.x.

7.
8.

Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling.

Kling RC, Lanig H, Clark T, Gmeiner P.

PLoS One. 2013 Jun 24;8(6):e67244. doi: 10.1371/journal.pone.0067244. Print 2013.

9.

Difference and Influence of Inactive and Active States of Cannabinoid Receptor Subtype CB2: From Conformation to Drug Discovery.

Hu J, Feng Z, Ma S, Zhang Y, Tong Q, Alqarni MH, Gou X, Xie XQ.

J Chem Inf Model. 2016 Jun 27;56(6):1152-63. doi: 10.1021/acs.jcim.5b00739. Epub 2016 May 26.

10.

A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor.

Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE.

J Biol Chem. 2016 Sep 9;291(37):19674-86. doi: 10.1074/jbc.M116.745513. Epub 2016 Jul 26.

11.

Modeling, molecular dynamics simulation, and mutation validation for structure of cannabinoid receptor 2 based on known crystal structures of GPCRs.

Feng Z, Alqarni MH, Yang P, Tong Q, Chowdhury A, Wang L, Xie XQ.

J Chem Inf Model. 2014 Sep 22;54(9):2483-99. doi: 10.1021/ci5002718. Epub 2014 Sep 5.

12.

A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.

Hurst DP, Grossfield A, Lynch DL, Feller S, Romo TD, Gawrisch K, Pitman MC, Reggio PH.

J Biol Chem. 2010 Jun 4;285(23):17954-64. doi: 10.1074/jbc.M109.041590. Epub 2010 Mar 10.

13.

Effect of N-Terminal Myristoylation on the Active Conformation of Gαi1-GTP.

van Keulen SC, Rothlisberger U.

Biochemistry. 2017 Jan 10;56(1):271-280. doi: 10.1021/acs.biochem.6b00388. Epub 2016 Dec 29.

PMID:
27936598
14.

Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor.

Zhang Y, Xie Z, Wang L, Schreiter B, Lazo JS, Gertsch J, Xie XQ.

Int Immunopharmacol. 2011 Sep;11(9):1303-10. doi: 10.1016/j.intimp.2011.04.013. Epub 2011 May 1.

15.

Mass Spectrometry Analysis of Human CB2 Cannabinoid Receptor and Its Associated Proteins.

Song ZH, Laun AS, Cai J.

Methods Enzymol. 2017;593:371-386. doi: 10.1016/bs.mie.2017.06.019. Epub 2017 Jul 13.

PMID:
28750811
16.

3D structural model of the G-protein-coupled cannabinoid CB2 receptor.

Xie XQ, Chen JZ, Billings EM.

Proteins. 2003 Nov 1;53(2):307-19.

PMID:
14517981
17.

Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gαi G-Protein Regulatory Motif Complex.

Robichaux WG 3rd, Oner SS, Lanier SM, Blumer JB.

Mol Pharmacol. 2015 Aug;88(2):231-7. doi: 10.1124/mol.115.097741. Epub 2015 May 13.

18.

Examining the critical roles of human CB2 receptor residues Valine 3.32 (113) and Leucine 5.41 (192) in ligand recognition and downstream signaling activities.

Alqarni M, Myint KZ, Tong Q, Yang P, Bartlow P, Wang L, Feng R, Xie XQ.

Biochem Biophys Res Commun. 2014 Sep 26;452(3):334-9. doi: 10.1016/j.bbrc.2014.08.048. Epub 2014 Aug 19.

19.

Biochemical and mass spectrometric characterization of the human CB2 cannabinoid receptor expressed in Pichia pastoris--importance of correct processing of the N-terminus.

Zhang R, Kim TK, Qiao ZH, Cai J, Pierce WM Jr, Song ZH.

Protein Expr Purif. 2007 Oct;55(2):225-35. Epub 2007 Apr 7.

PMID:
17500008
20.

Biochemical characterization of a heterotrimeric G(i)-protein activator peptide designed from the junction between the intracellular third loop and sixth transmembrane helix in the m4 muscarinic acetylcholine receptor.

Terawaki S, Matsubayashi R, Hara K, Onozuka T, Kohno T, Wakamatsu K.

Biochem Biophys Res Commun. 2015 Jul 17-24;463(1-2):64-9. doi: 10.1016/j.bbrc.2015.05.018. Epub 2015 May 16.

PMID:
25986737

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