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Items: 1 to 20 of 152

1.

Identification and characterization of small molecule human papillomavirus E6 inhibitors.

Malecka KA, Fera D, Schultz DC, Hodawadekar S, Reichman M, Donover PS, Murphy ME, Marmorstein R.

ACS Chem Biol. 2014 Jul 18;9(7):1603-12. doi: 10.1021/cb500229d. Epub 2014 Jun 2.

2.

Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function.

Cherry JJ, Rietz A, Malinkevich A, Liu Y, Xie M, Bartolowits M, Davisson VJ, Baleja JD, Androphy EJ.

PLoS One. 2013 Dec 23;8(12):e84506. doi: 10.1371/journal.pone.0084506. eCollection 2013.

3.

Small molecule inhibitors of the HPV16-E6 interaction with caspase 8.

Yuan CH, Filippova M, Tungteakkhun SS, Duerksen-Hughes PJ, Krstenansky JL.

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2125-9. doi: 10.1016/j.bmcl.2011.12.145. Epub 2012 Jan 10.

4.

Potential drugs against cervical cancer: zinc-ejecting inhibitors of the human papillomavirus type 16 E6 oncoprotein.

Beerheide W, Bernard HU, Tan YJ, Ganesan A, Rice WG, Ting AE.

J Natl Cancer Inst. 1999 Jul 21;91(14):1211-20.

PMID:
10413422
5.

Inhibition of papillomavirus protein function in cervical cancer cells by intrabody targeting.

Griffin H, Elston R, Jackson D, Ansell K, Coleman M, Winter G, Doorbar J.

J Mol Biol. 2006 Jan 20;355(3):360-78. Epub 2005 Nov 14.

PMID:
16324714
6.

Tanshinone IIA inhibits viral oncogene expression leading to apoptosis and inhibition of cervical cancer.

Munagala R, Aqil F, Jeyabalan J, Gupta RC.

Cancer Lett. 2015 Jan 28;356(2 Pt B):536-46. doi: 10.1016/j.canlet.2014.09.037. Epub 2014 Oct 7.

PMID:
25304375
7.

Activating transcription factor 3 activates p53 by preventing E6-associated protein from binding to E6.

Wang H, Mo P, Ren S, Yan C.

J Biol Chem. 2010 Apr 23;285(17):13201-10. doi: 10.1074/jbc.M109.058669. Epub 2010 Feb 18.

8.

Docosahexaenoic acid induces the degradation of HPV E6/E7 oncoproteins by activating the ubiquitin-proteasome system.

Jing K, Shin S, Jeong S, Kim S, Song KS, Park JH, Heo JY, Seo KS, Park SK, Kweon GR, Wu T, Park JI, Lim K.

Cell Death Dis. 2014 Nov 13;5:e1524. doi: 10.1038/cddis.2014.477.

9.

Honeybee venom possesses anticancer and antiviral effects by differential inhibition of HPV E6 and E7 expression on cervical cancer cell line.

Kim YW, Chaturvedi PK, Chun SN, Lee YG, Ahn WS.

Oncol Rep. 2015 Apr;33(4):1675-82. doi: 10.3892/or.2015.3760. Epub 2015 Jan 28.

PMID:
25633640
10.

Development of screening systems for drugs against human papillomavirus-associated cervical cancer: based on E6-E6AP binding.

Cho Y, Cho C, Joung O, Lee K, Park S, Yoon D.

Antiviral Res. 2000 Sep;47(3):199-206.

PMID:
10974372
11.

Alpha-linolenic acid regulates Cox2/VEGF/MAP kinase pathway and decreases the expression of HPV oncoproteins E6/E7 through restoration of p53 and Rb expression in human cervical cancer cell lines.

Deshpande R, Mansara P, Kaul-Ghanekar R.

Tumour Biol. 2016 Mar;37(3):3295-305. doi: 10.1007/s13277-015-4170-z. Epub 2015 Oct 6.

PMID:
26440049
12.

Withaferin A induces p53-dependent apoptosis by repression of HPV oncogenes and upregulation of tumor suppressor proteins in human cervical cancer cells.

Munagala R, Kausar H, Munjal C, Gupta RC.

Carcinogenesis. 2011 Nov;32(11):1697-705. doi: 10.1093/carcin/bgr192. Epub 2011 Aug 22.

PMID:
21859835
13.

The presence of human papillomavirus-16/-18 E6, p53, and Bcl-2 protein in cervicovaginal smears from patients with invasive cervical cancer.

Pillai MR, Halabi S, McKalip A, Jayaprakash PG, Rajalekshmi TN, Nair MK, Herman B.

Cancer Epidemiol Biomarkers Prev. 1996 May;5(5):329-35.

14.

Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis.

Oei AL, van Leeuwen CM, ten Cate R, Rodermond HM, Buist MR, Stalpers LJ, Crezee J, Kok HP, Medema JP, Franken NA.

Cancer Res. 2015 Dec 1;75(23):5120-9. doi: 10.1158/0008-5472.CAN-15-0816. Epub 2015 Nov 16.

15.

Artificial microRNAs against the viral E6 protein provoke apoptosis in HPV positive cancer cells.

Bonetta AC, Mailly L, Robinet E, Travé G, Masson M, Deryckere F.

Biochem Biophys Res Commun. 2015 Oct 2;465(4):658-64. doi: 10.1016/j.bbrc.2015.07.144. Epub 2015 Aug 1.

PMID:
26241675
16.

Warts, cancer and ubiquitylation: lessons from the papillomaviruses.

Howley PM.

Trans Am Clin Climatol Assoc. 2006;117:113-26; discussion 126-7. Review.

17.

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53.

Martinez-Zapien D, Ruiz FX, Poirson J, Mitschler A, Ramirez J, Forster A, Cousido-Siah A, Masson M, Vande Pol S, Podjarny A, Travé G, Zanier K.

Nature. 2016 Jan 28;529(7587):541-5. doi: 10.1038/nature16481. Epub 2016 Jan 20.

18.

GRIM-19 disrupts E6/E6AP complex to rescue p53 and induce apoptosis in cervical cancers.

Zhou Y, Wei Y, Zhu J, Wang Q, Bao L, Ma Y, Chen Y, Feng D, Zhang A, Sun J, Nallar SC, Shen K, Kalvakolanu DV, Xiao W, Ling B.

PLoS One. 2011;6(7):e22065. doi: 10.1371/journal.pone.0022065. Epub 2011 Jul 12.

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