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Items: 1 to 20 of 346

1.

A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA.

Burke JM, Kelenis DP, Kincaid RP, Sullivan CS.

RNA. 2014 Jul;20(7):1068-77. doi: 10.1261/rna.044537.114. Epub 2014 May 22.

2.

Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complex.

Han J, Lee Y, Yeom KH, Nam JW, Heo I, Rhee JK, Sohn SY, Cho Y, Zhang BT, Kim VN.

Cell. 2006 Jun 2;125(5):887-901.

3.

Lower and upper stem-single-stranded RNA junctions together determine the Drosha cleavage site.

Ma H, Wu Y, Choi JG, Wu H.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):20687-92. doi: 10.1073/pnas.1311639110. Epub 2013 Dec 2.

4.

The core microprocessor component DiGeorge syndrome critical region 8 (DGCR8) is a nonspecific RNA-binding protein.

Roth BM, Ishimaru D, Hennig M.

J Biol Chem. 2013 Sep 13;288(37):26785-99. doi: 10.1074/jbc.M112.446880. Epub 2013 Jul 26.

5.

DGCR8 recognizes primary transcripts of microRNAs through highly cooperative binding and formation of higher-order structures.

Faller M, Toso D, Matsunaga M, Atanasov I, Senturia R, Chen Y, Zhou ZH, Guo F.

RNA. 2010 Aug;16(8):1570-83. doi: 10.1261/rna.2111310. Epub 2010 Jun 17.

6.

Genome-wide Mapping of DROSHA Cleavage Sites on Primary MicroRNAs and Noncanonical Substrates.

Kim B, Jeong K, Kim VN.

Mol Cell. 2017 Apr 20;66(2):258-269.e5. doi: 10.1016/j.molcel.2017.03.013.

PMID:
28431232
7.

Characterization of DGCR8/Pasha, the essential cofactor for Drosha in primary miRNA processing.

Yeom KH, Lee Y, Han J, Suh MR, Kim VN.

Nucleic Acids Res. 2006;34(16):4622-9. Epub 2006 Sep 8.

8.

Autoantigen La Regulates MicroRNA Processing from Stem-Loop Precursors by Association with DGCR8.

Zheng Q, Yang HJ, Yuan YA.

Biochemistry. 2017 Nov 21;56(46):6098-6110. doi: 10.1021/acs.biochem.7b00693. Epub 2017 Nov 8.

PMID:
29087193
9.

The kinase ABL phosphorylates the microprocessor subunit DGCR8 to stimulate primary microRNA processing in response to DNA damage.

Tu CC, Zhong Y, Nguyen L, Tsai A, Sridevi P, Tarn WY, Wang JY.

Sci Signal. 2015 Jun 30;8(383):ra64. doi: 10.1126/scisignal.aaa4468.

10.

Recognition and cleavage of primary microRNA precursors by the nuclear processing enzyme Drosha.

Zeng Y, Yi R, Cullen BR.

EMBO J. 2005 Jan 12;24(1):138-48. Epub 2004 Nov 25.

11.

Association of a peptoid ligand with the apical loop of pri-miR-21 inhibits cleavage by Drosha.

Diaz JP, Chirayil R, Chirayil S, Tom M, Head KJ, Luebke KJ.

RNA. 2014 Apr;20(4):528-39. doi: 10.1261/rna.042911.113. Epub 2014 Feb 4.

12.

N6-methyladenosine marks primary microRNAs for processing.

Alarcón CR, Lee H, Goodarzi H, Halberg N, Tavazoie SF.

Nature. 2015 Mar 26;519(7544):482-5. doi: 10.1038/nature14281. Epub 2015 Mar 18.

13.

Functional Anatomy of the Human Microprocessor.

Nguyen TA, Jo MH, Choi YG, Park J, Kwon SC, Hohng S, Kim VN, Woo JS.

Cell. 2015 Jun 4;161(6):1374-87. doi: 10.1016/j.cell.2015.05.010. Epub 2015 May 28.

14.

Primary microRNA processing assay reconstituted using recombinant Drosha and DGCR8.

Barr I, Guo F.

Methods Mol Biol. 2014;1095:73-86. doi: 10.1007/978-1-62703-703-7_5.

15.

Rare Drosha splice variants are deficient in microRNA processing but do not affect general microRNA expression in cancer cells.

Grund SE, Polycarpou-Schwarz M, Luo C, Eichmüller SB, Diederichs S.

Neoplasia. 2012 Mar;14(3):238-48.

16.

A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.

Herbert KM, Sarkar SK, Mills M, Delgado De la Herran HC, Neuman KC, Steitz JA.

RNA. 2016 Feb;22(2):175-83. doi: 10.1261/rna.054684.115. Epub 2015 Dec 18.

17.

Processing of microRNA primary transcripts requires heme in mammalian cells.

Weitz SH, Gong M, Barr I, Weiss S, Guo F.

Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1861-6. doi: 10.1073/pnas.1309915111. Epub 2014 Jan 21.

18.

Bidirectional processing of pri-miRNAs with branched terminal loops by Arabidopsis Dicer-like1.

Zhu H, Zhou Y, Castillo-González C, Lu A, Ge C, Zhao YT, Duan L, Li Z, Axtell MJ, Wang XJ, Zhang X.

Nat Struct Mol Biol. 2013 Sep;20(9):1106-15. doi: 10.1038/nsmb.2646. Epub 2013 Aug 11.

19.

RNA editing of the microRNA-151 precursor blocks cleavage by the Dicer-TRBP complex.

Kawahara Y, Zinshteyn B, Chendrimada TP, Shiekhattar R, Nishikura K.

EMBO Rep. 2007 Aug;8(8):763-9. Epub 2007 Jun 22.

20.

The Drosha-DGCR8 complex in primary microRNA processing.

Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN.

Genes Dev. 2004 Dec 15;18(24):3016-27. Epub 2004 Dec 1.

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