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Monocytes and CD4+ T cells contribution to the under-expression of NR4A2 and TNFAIP3 genes in patients with multiple sclerosis.

Navone ND, Perga S, Martire S, Berchialla P, Malucchi S, Bertolotto A.

J Neuroimmunol. 2014 Jul 15;272(1-2):99-102. doi: 10.1016/j.jneuroim.2014.04.017. Epub 2014 May 10.


Loss of braking signals during inflammation: a factor affecting the development and disease course of multiple sclerosis.

Gilli F, Navone ND, Perga S, Marnetto F, Caldano M, Capobianco M, Pulizzi A, Malucchi S, Bertolotto A.

Arch Neurol. 2011 Jul;68(7):879-88. doi: 10.1001/archneurol.2011.32. Epub 2011 Mar 14.


Association of TNFAIP3 and TNFRSF1A variation with multiple sclerosis in a German case-control cohort.

Hoffjan S, Okur A, Epplen JT, Wieczorek S, Chan A, Akkad DA.

Int J Immunogenet. 2015 Apr;42(2):106-10. doi: 10.1111/iji.12183. Epub 2015 Feb 12.


Expression of tumor necrosis factor alpha-induced protein 3 mRNA in peripheral blood mononuclear cells negatively correlates with disease severity in psoriasis vulgaris.

Jiang X, Tian H, Fan Y, Chen J, Song Y, Wang S, Zhu F, Guo C, Zhang L, Shi Y.

Clin Vaccine Immunol. 2012 Dec;19(12):1938-42. doi: 10.1128/CVI.00500-12. Epub 2012 Oct 10.


Adenosine Modulates NR4A Orphan Nuclear Receptors To Attenuate Hyperinflammatory Responses in Monocytic Cells.

Crean D, Cummins EP, Bahar B, Mohan H, McMorrow JP, Murphy EP.

J Immunol. 2015 Aug 15;195(4):1436-48. doi: 10.4049/jimmunol.1402039. Epub 2015 Jul 6.


A failure of TNFAIP3 negative regulation maintains sustained NF-κB activation in Sjögren's syndrome.

Sisto M, Lisi S, Lofrumento DD, Ingravallo G, Maiorano E, D'Amore M.

Histochem Cell Biol. 2011 Jun;135(6):615-25. doi: 10.1007/s00418-011-0821-3. Epub 2011 May 21.


Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer.

Ungerbäck J, Belenki D, Jawad ul-Hassan A, Fredrikson M, Fransén K, Elander N, Verma D, Söderkvist P.

Carcinogenesis. 2012 Nov;33(11):2126-34. doi: 10.1093/carcin/bgs256. Epub 2012 Jul 28.


MiR-126: a novel route for natalizumab action?

Meira M, Sievers C, Hoffmann F, Derfuss T, Kuhle J, Kappos L, Lindberg RL.

Mult Scler. 2014 Sep;20(10):1363-70. doi: 10.1177/1352458514524998. Epub 2014 Mar 5.


Dysregulated neurotrophin mRNA production by immune cells of patients with relapsing remitting multiple sclerosis.

Urshansky N, Mausner-Fainberg K, Auriel E, Regev K, Farhum F, Karni A.

J Neurol Sci. 2010 Aug 15;295(1-2):31-7. doi: 10.1016/j.jns.2010.05.019. Epub 2010 Jun 11.


Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity.

McMorrow JP, Crean D, Gogarty M, Smyth A, Connolly M, Cummins E, Veale D, Fearon U, Tak PP, Fitzgerald O, Murphy EP.

Am J Pathol. 2013 Oct;183(4):1243-57. doi: 10.1016/j.ajpath.2013.06.029. Epub 2013 Aug 6.


Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine.

Breckpot K, Aerts-Toegaert C, Heirman C, Peeters U, Beyaert R, Aerts JL, Thielemans K.

J Immunol. 2009 Jan 15;182(2):860-70.


Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis.

Romme Christensen J, Börnsen L, Hesse D, Krakauer M, Sørensen PS, Søndergaard HB, Sellebjerg F.

J Neuroinflammation. 2012 Sep 14;9:215. doi: 10.1186/1742-2094-9-215.


Endogenous interferon-β-inducible gene expression and interferon-β-treatment are associated with reduced T cell responses to myelin basic protein in multiple sclerosis.

Börnsen L, Romme Christensen J, Ratzer R, Hedegaard C, Søndergaard HB, Krakauer M, Hesse D, Nielsen CH, Sorensen PS, Sellebjerg F.

PLoS One. 2015 Mar 4;10(3):e0118830. doi: 10.1371/journal.pone.0118830. eCollection 2015.


Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability.

Prat A, Biernacki K, Saroli T, Orav JE, Guttmann CR, Weiner HL, Khoury SJ, Antel JP.

Arch Neurol. 2005 May;62(5):795-800.


The role of fractalkine (CX3CL1) in regulation of CD4(+) cell migration to the central nervous system in patients with relapsing-remitting multiple sclerosis.

Blauth K, Zhang X, Chopra M, Rogan S, Markovic-Plese S.

Clin Immunol. 2015 Apr;157(2):121-32. doi: 10.1016/j.clim.2015.01.001. Epub 2015 Jan 14.


Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity.

Koumakis E, Giraud M, Dieudé P, Cohignac V, Cuomo G, Airò P, Hachulla E, Matucci-Cerinic M, Diot E, Caramaschi P, Mouthon L, Riccieri V, Cracowski JL, Tiev KP, Francès C, Amoura Z, Sibilia J, Cosnes A, Carpentier P, Valentini G, Manetti M, Guiducci S, Meyer O, Kahan A, Boileau C, Chiocchia G, Allanore Y.

Arthritis Rheum. 2012 Aug;64(8):2746-52. doi: 10.1002/art.34490.


Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis.

Aherne CM, McMorrow J, Kane D, FitzGerald O, Mix KS, Murphy EP.

Mol Immunol. 2009 Oct;46(16):3345-57. doi: 10.1016/j.molimm.2009.07.019. Epub 2009 Sep 3.


miR-125b controls apoptosis and temozolomide resistance by targeting TNFAIP3 and NKIRAS2 in glioblastomas.

Haemmig S, Baumgartner U, Glück A, Zbinden S, Tschan MP, Kappeler A, Mariani L, Vajtai I, Vassella E.

Cell Death Dis. 2014 Jun 5;5:e1279. doi: 10.1038/cddis.2014.245.


Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma.

Bu R, Bavi P, Abubaker J, Jehan Z, Al-Haqawi W, Ajarim D, Al-Dayel F, Uddin S, Al-Kuraya KS.

Leuk Lymphoma. 2012 Oct;53(10):1971-7. doi: 10.3109/10428194.2012.668286. Epub 2012 Apr 18.


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