Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 89

1.

Modeling LRRK2 Pathobiology in Parkinson's Disease: From Yeast to Rodents.

Daniel G, Moore DJ.

Curr Top Behav Neurosci. 2015;22:331-68. doi: 10.1007/7854_2014_311. Review.

PMID:
24850078
2.

Contribution of GTPase activity to LRRK2-associated Parkinson disease.

Tsika E, Moore DJ.

Small GTPases. 2013 Jul-Sep;4(3):164-70. doi: 10.4161/sgtp.25130. Epub 2013 Jun 10. Review.

4.

Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants.

Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z.

J Neurochem. 2007 Oct;103(1):238-47. Epub 2007 Jul 10.

5.

LRRK2 in Parkinson's disease: protein domains and functional insights.

Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, Gallo KA.

Trends Neurosci. 2006 May;29(5):286-93. Epub 2006 Apr 17. Review.

PMID:
16616379
6.

Small molecule kinase inhibitors for LRRK2 and their application to Parkinson's disease models.

Kramer T, Lo Monte F, Göring S, Okala Amombo GM, Schmidt B.

ACS Chem Neurosci. 2012 Mar 21;3(3):151-60. doi: 10.1021/cn200117j. Epub 2012 Jan 18. Review.

7.

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity.

Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG.

Exp Cell Res. 2007 Oct 1;313(16):3658-70. Epub 2007 Jul 19.

8.

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

Rudenko IN, Chia R, Cookson MR.

BMC Med. 2012 Feb 23;10:20. doi: 10.1186/1741-7015-10-20. Review.

9.

GTPase activity plays a key role in the pathobiology of LRRK2.

Xiong Y, Coombes CE, Kilaru A, Li X, Gitler AD, Bowers WJ, Dawson VL, Dawson TM, Moore DJ.

PLoS Genet. 2010 Apr 8;6(4):e1000902. doi: 10.1371/journal.pgen.1000902.

10.

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease.

Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T.

Biochemistry. 2007 Feb 6;46(5):1380-8.

PMID:
17260967
11.

The Parkinson disease gene LRRK2: evolutionary and structural insights.

Marín I.

Mol Biol Evol. 2006 Dec;23(12):2423-33. Epub 2006 Sep 11.

PMID:
16966681
12.

LRRK2 in Parkinson's disease: in vivo models and approaches for understanding pathogenic roles.

Yue Z.

FEBS J. 2009 Nov;276(22):6445-54. doi: 10.1111/j.1742-4658.2009.07343.x. Epub 2009 Oct 5. Review.

13.

The biology and pathobiology of LRRK2: implications for Parkinson's disease.

Moore DJ.

Parkinsonism Relat Disord. 2008;14 Suppl 2:S92-8. doi: 10.1016/j.parkreldis.2008.04.010. Epub 2008 Jul 7. Review.

PMID:
18602856
14.

Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease.

Gómez-Suaga P, Fdez E, Fernández B, Martínez-Salvador M, Blanca Ramírez M, Madero-Pérez J, Rivero-Ríos P, Fuentes JM, Hilfiker S.

Neuropharmacology. 2014 Oct;85:45-56. doi: 10.1016/j.neuropharm.2014.05.020. Epub 2014 May 24. Review.

PMID:
24863040
15.

Conformational heterogeneity of the Roc domains in C. tepidum Roc-COR and implications for human LRRK2 Parkinson mutations.

Rudi K, Ho FY, Gilsbach BK, Pots H, Wittinghofer A, Kortholt A, Klare JP.

Biosci Rep. 2015 Aug 26;35(5). pii: e00254. doi: 10.1042/BSR20150128.

16.

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity.

Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M.

Hum Mol Genet. 2006 Jan 15;15(2):223-32. Epub 2005 Dec 1.

PMID:
16321986
17.

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.

Sancho RM, Law BM, Harvey K.

Hum Mol Genet. 2009 Oct 15;18(20):3955-68. doi: 10.1093/hmg/ddp337. Epub 2009 Jul 22.

18.

Prediction of the repeat domain structures and impact of parkinsonism-associated variations on structure and function of all functional domains of leucine-rich repeat kinase 2 (LRRK2).

Mills RD, Mulhern TD, Liu F, Culvenor JG, Cheng HC.

Hum Mutat. 2014 Apr;35(4):395-412. doi: 10.1002/humu.22515. Epub 2014 Feb 24. Review.

PMID:
24470158
19.

ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.

Verma M, Steer EK, Chu CT.

Biochim Biophys Acta. 2014 Aug;1842(8):1273-81. doi: 10.1016/j.bbadis.2013.11.005. Epub 2013 Nov 10. Review.

20.

LRRK2 and vesicle trafficking.

Sanna G, Del Giudice MG, Crosio C, Iaccarino C.

Biochem Soc Trans. 2012 Oct;40(5):1117-22. Review.

PMID:
22988875

Supplemental Content

Support Center