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Items: 1 to 20 of 107

1.

Improving the stability and catalyst lifetime of the halogenase RebH by directed evolution.

Poor CB, Andorfer MC, Lewis JC.

Chembiochem. 2014 Jun 16;15(9):1286-9. doi: 10.1002/cbic.201300780. Epub 2014 May 21.

2.

Directed evolution of RebH for site-selective halogenation of large biologically active molecules.

Payne JT, Poor CB, Lewis JC.

Angew Chem Int Ed Engl. 2015 Mar 27;54(14):4226-30. doi: 10.1002/anie.201411901. Epub 2015 Feb 9.

3.

Halogenase Engineering for the Generation of New Natural Product Analogues.

Brown S, O'Connor SE.

Chembiochem. 2015 Oct 12;16(15):2129-35. doi: 10.1002/cbic.201500338. Epub 2015 Sep 4. Review.

PMID:
26256103
4.

Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor.

Glenn WS, Nims E, O'Connor SE.

J Am Chem Soc. 2011 Dec 7;133(48):19346-9. doi: 10.1021/ja2089348. Epub 2011 Nov 11.

PMID:
22050348
5.
6.

Regioselective arene halogenation using the FAD-dependent halogenase RebH.

Payne JT, Andorfer MC, Lewis JC.

Angew Chem Int Ed Engl. 2013 May 10;52(20):5271-4. doi: 10.1002/anie.201300762. Epub 2013 Apr 16. No abstract available.

7.

Structure and action of the myxobacterial chondrochloren halogenase CndH: a new variant of FAD-dependent halogenases.

Buedenbender S, Rachid S, Müller R, Schulz GE.

J Mol Biol. 2009 Jan 16;385(2):520-30. doi: 10.1016/j.jmb.2008.10.057. Epub 2008 Oct 30.

PMID:
19000696
8.

Directed Evolution of RebH for Catalyst-Controlled Halogenation of Indole C-H Bonds.

Andorfer MC, Park HJ, Vergara-Coll J, Lewis JC.

Chem Sci. 2016 Jun 1;7(6):3720-3729. Epub 2016 Feb 19.

9.

A Structure-Guided Switch in the Regioselectivity of a Tryptophan Halogenase.

Shepherd SA, Menon BR, Fisk H, Struck AW, Levy C, Leys D, Micklefield J.

Chembiochem. 2016 May 3;17(9):821-4. doi: 10.1002/cbic.201600051. Epub 2016 Mar 30.

10.

Enzymatic halogenation of tryptophan on a gram scale.

Frese M, Sewald N.

Angew Chem Int Ed Engl. 2015 Jan 2;54(1):298-301. doi: 10.1002/anie.201408561. Epub 2014 Nov 12.

PMID:
25394328
11.

Structural insights into regioselectivity in the enzymatic chlorination of tryptophan.

Zhu X, De Laurentis W, Leang K, Herrmann J, Ihlefeld K, van Pée KH, Naismith JH.

J Mol Biol. 2009 Aug 7;391(1):74-85. doi: 10.1016/j.jmb.2009.06.008. Epub 2009 Jun 6.

12.

The structure of flavin-dependent tryptophan 7-halogenase RebH.

Bitto E, Huang Y, Bingman CA, Singh S, Thorson JS, Phillips GN Jr.

Proteins. 2008 Jan 1;70(1):289-93. No abstract available.

PMID:
17876823
13.

Chloramphenicol biosynthesis: the structure of CmlS, a flavin-dependent halogenase showing a covalent flavin-aspartate bond.

Podzelinska K, Latimer R, Bhattacharya A, Vining LC, Zechel DL, Jia Z.

J Mol Biol. 2010 Mar 19;397(1):316-31. doi: 10.1016/j.jmb.2010.01.020. Epub 2010 Jan 18.

PMID:
20080101
14.

Changing the regioselectivity of the tryptophan 7-halogenase PrnA by site-directed mutagenesis.

Lang A, Polnick S, Nicke T, William P, Patallo EP, Naismith JH, van Pée KH.

Angew Chem Int Ed Engl. 2011 Mar 21;50(13):2951-3. doi: 10.1002/anie.201007896. Epub 2011 Feb 25. No abstract available.

PMID:
21404376
15.

Flavin redox chemistry precedes substrate chlorination during the reaction of the flavin-dependent halogenase RebH.

Yeh E, Cole LJ, Barr EW, Bollinger JM Jr, Ballou DP, Walsh CT.

Biochemistry. 2006 Jun 27;45(25):7904-12.

PMID:
16784243
16.

Chlorination by a long-lived intermediate in the mechanism of flavin-dependent halogenases.

Yeh E, Blasiak LC, Koglin A, Drennan CL, Walsh CT.

Biochemistry. 2007 Feb 6;46(5):1284-92.

PMID:
17260957
17.

Improving and repurposing biocatalysts via directed evolution.

Denard CA, Ren H, Zhao H.

Curr Opin Chem Biol. 2015 Apr;25:55-64. doi: 10.1016/j.cbpa.2014.12.036. Epub 2015 Jan 8. Review.

PMID:
25579451
18.

Directed evolution of enzymes for applied biocatalysis.

Turner NJ.

Trends Biotechnol. 2003 Nov;21(11):474-8.

PMID:
14573359
19.

Structure-Guided Reprogramming of a Hydroxylase To Halogenate Its Small Molecule Substrate.

Mitchell AJ, Dunham NP, Bergman JA, Wang B, Zhu Q, Chang WC, Liu X, Boal AK.

Biochemistry. 2017 Jan 24;56(3):441-444. doi: 10.1021/acs.biochem.6b01173. Epub 2017 Jan 11.

PMID:
28029241
20.

Elucidation of the Fe(IV)=O intermediate in the catalytic cycle of the halogenase SyrB2.

Wong SD, Srnec M, Matthews ML, Liu LV, Kwak Y, Park K, Bell CB 3rd, Alp EE, Zhao J, Yoda Y, Kitao S, Seto M, Krebs C, Bollinger JM Jr, Solomon EI.

Nature. 2013 Jul 18;499(7458):320-3. doi: 10.1038/nature12304.

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