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Items: 1 to 20 of 84

1.

Squalene mono-oxygenase, a key enzyme in cholesterol synthesis, is stabilized by unsaturated fatty acids.

Stevenson J, Luu W, Kristiana I, Brown AJ.

Biochem J. 2014 Aug 1;461(3):435-42. doi: 10.1042/BJ20131404.

PMID:
24840124
2.

The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.

Zelcer N, Sharpe LJ, Loregger A, Kristiana I, Cook EC, Phan L, Stevenson J, Brown AJ.

Mol Cell Biol. 2014 Apr;34(7):1262-70. doi: 10.1128/MCB.01140-13. Epub 2014 Jan 21.

3.

The Regulatory Domain of Squalene Monooxygenase Contains a Re-entrant Loop and Senses Cholesterol via a Conformational Change.

Howe V, Chua NK, Stevenson J, Brown AJ.

J Biol Chem. 2015 Nov 13;290(46):27533-44. doi: 10.1074/jbc.M115.675181. Epub 2015 Oct 3.

4.

Cholesterol-dependent degradation of squalene monooxygenase, a control point in cholesterol synthesis beyond HMG-CoA reductase.

Gill S, Stevenson J, Kristiana I, Brown AJ.

Cell Metab. 2011 Mar 2;13(3):260-73. doi: 10.1016/j.cmet.2011.01.015.

5.

Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.

Mokashi V, Singh DK, Porter TD.

Arch Biochem Biophys. 2005 Jan 15;433(2):474-80.

PMID:
15581604
6.

Unsaturated fatty acids inhibit proteasomal degradation of Insig-1 at a postubiquitination step.

Lee JN, Zhang X, Feramisco JD, Gong Y, Ye J.

J Biol Chem. 2008 Nov 28;283(48):33772-83. doi: 10.1074/jbc.M806108200. Epub 2008 Oct 3.

7.

A MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.

Loregger A, Cook EC, Nelson JK, Moeton M, Sharpe LJ, Engberg S, Karimova M, Lambert G, Brown AJ, Zelcer N.

Mol Cell Biol. 2015 Nov 2;36(2):285-94. doi: 10.1128/MCB.00890-15.

8.
9.

Ubiquitin-specific protease 19 regulates the stability of the E3 ubiquitin ligase MARCH6.

Nakamura N, Harada K, Kato M, Hirose S.

Exp Cell Res. 2014 Oct 15;328(1):207-16. doi: 10.1016/j.yexcr.2014.07.025. Epub 2014 Aug 1.

PMID:
25088257
10.

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis.

Honsho M, Abe Y, Fujiki Y.

J Biol Chem. 2015 Nov 27;290(48):28822-33. doi: 10.1074/jbc.M115.656983. Epub 2015 Oct 13.

11.
12.

Evidence for adipose-muscle cross talk: opposing regulation of muscle proteolysis by adiponectin and Fatty acids.

Zhou Q, Du J, Hu Z, Walsh K, Wang XH.

Endocrinology. 2007 Dec;148(12):5696-705. Epub 2007 Aug 30.

PMID:
17761767
13.

A role for MGA2, but not SPT23, in activation of transcription of ERG1 in Saccharomyces cerevisiae.

Rice C, Cooke M, Treloar N, Vollbrecht P, Stukey J, McDonough V.

Biochem Biophys Res Commun. 2010 Dec 17;403(3-4):293-7. doi: 10.1016/j.bbrc.2010.11.020. Epub 2010 Nov 12.

PMID:
21075079
14.

Regulation of squalene epoxidase activity by membrane fatty acid composition in yeast.

Buttke TM, Brint SL, Lowe MR.

Lipids. 1988 Jan;23(1):68-71.

PMID:
3280941
16.

A Conserved Degron Containing an Amphipathic Helix Regulates the Cholesterol-Mediated Turnover of Human Squalene Monooxygenase, a Rate-Limiting Enzyme in Cholesterol Synthesis.

Chua NK, Howe V, Jatana N, Thukral L, Brown AJ.

J Biol Chem. 2017 Sep 27. pii: jbc.M117.794230. doi: 10.1074/jbc.M117.794230. [Epub ahead of print]

17.

Protein turnover regulated by cholesterol.

Kim MJ, Jessup W.

Curr Opin Lipidol. 2012 Feb;23(1):76-7. doi: 10.1097/MOL.0b013e32834f42b3. No abstract available.

PMID:
22241328
18.

Rat long chain acyl-CoA synthetase 5 increases fatty acid uptake and partitioning to cellular triacylglycerol in McArdle-RH7777 cells.

Mashek DG, McKenzie MA, Van Horn CG, Coleman RA.

J Biol Chem. 2006 Jan 13;281(2):945-50. Epub 2005 Nov 1.

19.

Modulation of phosphatidylcholine biosynthesis in celery by exogenous fatty acids.

Parkin ET, Rolph CE.

Phytochemistry. 1999 Jan;50(1):47-51.

PMID:
9891932

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