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Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.

McGill MR, Jaeschke H.

Expert Opin Drug Metab Toxicol. 2014 Jul;10(7):1005-17. doi: 10.1517/17425255.2014.920823. Epub 2014 May 16. Review.


Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients.

Jaeschke H.

Dig Dis. 2015;33(4):464-71. doi: 10.1159/000374090. Epub 2015 Jul 6. Review.


The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation.

McGill MR, Sharpe MR, Williams CD, Taha M, Curry SC, Jaeschke H.

J Clin Invest. 2012 Apr;122(4):1574-83. doi: 10.1172/JCI59755. Epub 2012 Mar 1.


Pathophysiological significance of c-jun N-terminal kinase in acetaminophen hepatotoxicity.

Du K, Xie Y, McGill MR, Jaeschke H.

Expert Opin Drug Metab Toxicol. 2015;11(11):1769-79. doi: 10.1517/17425255.2015.1071353. Epub 2015 Jul 20. Review.


Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans.

McGill MR, Li F, Sharpe MR, Williams CD, Curry SC, Ma X, Jaeschke H.

Arch Toxicol. 2014 Feb;88(2):391-401. doi: 10.1007/s00204-013-1118-1. Epub 2013 Aug 25.


Acetaminophen-related hepatotoxicity.

Bunchorntavakul C, Reddy KR.

Clin Liver Dis. 2013 Nov;17(4):587-607, viii. doi: 10.1016/j.cld.2013.07.005. Epub 2013 Sep 4. Review.


Serum mitochondrial biomarkers and damage-associated molecular patterns are higher in acetaminophen overdose patients with poor outcome.

McGill MR, Staggs VS, Sharpe MR, Lee WM, Jaeschke H; Acute Liver Failure Study Group.

Hepatology. 2014 Oct;60(4):1336-45. doi: 10.1002/hep.27265. Epub 2014 Aug 25.


Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity.

Jaeschke H, McGill MR, Ramachandran A.

Drug Metab Rev. 2012 Feb;44(1):88-106. doi: 10.3109/03602532.2011.602688. Epub 2012 Jan 10. Review.


Risk Factors, Clinical Presentation, and Outcomes in Overdose With Acetaminophen Alone or With Combination Products: Results From the Acute Liver Failure Study Group.

Serper M, Wolf MS, Parikh NA, Tillman H, Lee WM, Ganger DR.

J Clin Gastroenterol. 2016 Jan;50(1):85-91. doi: 10.1097/MCG.0000000000000378.


Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity.

Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, Craig DG, Simpson KJ, Jaeschke H, Park BK.

J Hepatol. 2012 May;56(5):1070-9. doi: 10.1016/j.jhep.2011.12.019. Epub 2012 Jan 17.


Gab1 adaptor protein acts as a gatekeeper to balance hepatocyte death and proliferation during acetaminophen-induced liver injury in mice.

Furuta K, Yoshida Y, Ogura S, Kurahashi T, Kizu T, Maeda S, Egawa M, Chatani N, Nishida K, Nakaoka Y, Kiso S, Kamada Y, Takehara T.

Hepatology. 2016 Apr;63(4):1340-55. doi: 10.1002/hep.28410. Epub 2016 Jan 22.


Reversal of bioenergetics dysfunction by diphenyl diselenide is critical to protection against the acetaminophen-induced acute liver failure.

Carvalho NR, Tassi CC, Dobraschinski F, Amaral GP, Zemolin AP, Golombieski RM, Dalla Corte CL, Franco JL, Mauriz JL, González-Gallego J, Soares FA.

Life Sci. 2017 Jul 1;180:42-50. doi: 10.1016/j.lfs.2017.05.012. Epub 2017 May 10.


Resveratrol prevents protein nitration and release of endonucleases from mitochondria during acetaminophen hepatotoxicity.

Du K, McGill MR, Xie Y, Bajt ML, Jaeschke H.

Food Chem Toxicol. 2015 Jul;81:62-70. doi: 10.1016/j.fct.2015.04.014. Epub 2015 Apr 9.


Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice.

Lin Z, Wu F, Lin S, Pan X, Jin L, Lu T, Shi L, Wang Y, Xu A, Li X.

J Hepatol. 2014 Oct;61(4):825-31. doi: 10.1016/j.jhep.2014.05.033. Epub 2014 Jun 2.


The protective role of NAD(P)H:quinone oxidoreductase 1 on acetaminophen-induced liver injury is associated with prevention of adenosine triphosphate depletion and improvement of mitochondrial dysfunction.

Hwang JH, Kim YH, Noh JR, Gang GT, Kim KS, Chung HK, Tadi S, Yim YH, Shong M, Lee CH.

Arch Toxicol. 2015 Nov;89(11):2159-66. doi: 10.1007/s00204-014-1340-5. Epub 2014 Sep 17.


The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.

Ramachandran A, Lebofsky M, Weinman SA, Jaeschke H.

Toxicol Appl Pharmacol. 2011 Mar 15;251(3):226-33. doi: 10.1016/j.taap.2011.01.004. Epub 2011 Jan 15.


Stratification of paracetamol overdose patients using new toxicity biomarkers: current candidates and future challenges.

Dear JW, Antoine DJ.

Expert Rev Clin Pharmacol. 2014 Mar;7(2):181-9. doi: 10.1586/17512433.2014.880650. Epub 2014 Jan 22. Review.


Application of high-throughput sequencing to circulating microRNAs reveals novel biomarkers for drug-induced liver injury.

Krauskopf J, Caiment F, Claessen SM, Johnson KJ, Warner RL, Schomaker SJ, Burt DA, Aubrecht J, Kleinjans JC.

Toxicol Sci. 2015 Feb;143(2):268-76. doi: 10.1093/toxsci/kfu232. Epub 2014 Oct 29.


Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.

Bajt ML, Ramachandran A, Yan HM, Lebofsky M, Farhood A, Lemasters JJ, Jaeschke H.

Toxicol Sci. 2011 Aug;122(2):598-605. doi: 10.1093/toxsci/kfr116. Epub 2011 May 13.


Neutrophil activation during acetaminophen hepatotoxicity and repair in mice and humans.

Williams CD, Bajt ML, Sharpe MR, McGill MR, Farhood A, Jaeschke H.

Toxicol Appl Pharmacol. 2014 Mar 1;275(2):122-33. doi: 10.1016/j.taap.2014.01.004. Epub 2014 Jan 15.

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