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The downregulation of GFI1 by the EZH2-NDY1/KDM2B-JARID2 axis and by human cytomegalovirus (HCMV) associated factors allows the activation of the HCMV major IE promoter and the transition to productive infection.

Sourvinos G, Morou A, Sanidas I, Codruta I, Ezell SA, Doxaki C, Kampranis SC, Kottakis F, Tsichlis PN.

PLoS Pathog. 2014 May 15;10(5):e1004136. doi: 10.1371/journal.ppat.1004136. eCollection 2014 May.


FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway.

Kottakis F, Polytarchou C, Foltopoulou P, Sanidas I, Kampranis SC, Tsichlis PN.

Mol Cell. 2011 Jul 22;43(2):285-98. doi: 10.1016/j.molcel.2011.06.020.


Chromatin-Remodeling Factor SPOC1 Acts as a Cellular Restriction Factor against Human Cytomegalovirus by Repressing the Major Immediate Early Promoter.

Reichel A, Stilp AC, Scherer M, Reuter N, Lukassen S, Kasmapour B, Schreiner S, Cicin-Sain L, Winterpacht A, Stamminger T.

J Virol. 2018 Jun 29;92(14). pii: e00342-18. doi: 10.1128/JVI.00342-18. Print 2018 Jul 15.


NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.

Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN.

Cancer Res. 2014 Jul 15;74(14):3935-46. doi: 10.1158/0008-5472.CAN-13-2733. Epub 2014 May 22.


Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.

Tzatsos A, Paskaleva P, Lymperi S, Contino G, Stoykova S, Chen Z, Wong KK, Bardeesy N.

J Biol Chem. 2011 Sep 23;286(38):33061-9. doi: 10.1074/jbc.M111.257667. Epub 2011 Jul 11.


The KDM2B- let-7b -EZH2 axis in myelodysplastic syndromes as a target for combined epigenetic therapy.

Karoopongse E, Yeung C, Byon J, Ramakrishnan A, Holman ZJ, Jiang PY, Yu Q, Deeg HJ, Marcondes AM.

PLoS One. 2014 Sep 16;9(9):e107817. doi: 10.1371/journal.pone.0107817. eCollection 2014.


Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus.

Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2641-6. doi: 10.1073/pnas.0813139106. Epub 2009 Feb 6.


RNA interference-mediated targeting of human cytomegalovirus immediate-early or early gene products inhibits viral replication with differential effects on cellular functions.

Xiaofei E, Stadler BM, Debatis M, Wang S, Lu S, Kowalik TF.

J Virol. 2012 May;86(10):5660-73. doi: 10.1128/JVI.06338-11. Epub 2012 Mar 21.


E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection.

Wade M, Kowalik TF, Mudryj M, Huang ES, Azizkhan JC.

Mol Cell Biol. 1992 Oct;12(10):4364-74.


CTCF binding to the first intron of the major immediate early (MIE) gene of human cytomegalovirus (HCMV) negatively regulates MIE gene expression and HCMV replication.

Martínez FP, Cruz R, Lu F, Plasschaert R, Deng Z, Rivera-Molina YA, Bartolomei MS, Lieberman PM, Tang Q.

J Virol. 2014 Jul;88(13):7389-401. doi: 10.1128/JVI.00845-14. Epub 2014 Apr 16.


Polycomb recruitment at the Class II transactivator gene.

Boyd NH, Morgan JE, Greer SF.

Mol Immunol. 2015 Oct;67(2 Pt B):482-91. doi: 10.1016/j.molimm.2015.08.003. Epub 2015 Aug 15.


Role of the cellular protein hDaxx in human cytomegalovirus immediate-early gene expression.

Preston CM, Nicholl MJ.

J Gen Virol. 2006 May;87(Pt 5):1113-21.


Histone deacetylase inhibitors deplete enhancer of zeste 2 and associated polycomb repressive complex 2 proteins in human acute leukemia cells.

Fiskus W, Pranpat M, Balasis M, Herger B, Rao R, Chinnaiyan A, Atadja P, Bhalla K.

Mol Cancer Ther. 2006 Dec;5(12):3096-104.


Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma.

Vo BT, Li C, Morgan MA, Theurillat I, Finkelstein D, Wright S, Hyle J, Smith SMC, Fan Y, Wang YD, Wu G, Orr BA, Northcott PA, Shilatifard A, Sherr CJ, Roussel MF.

Cell Rep. 2017 Mar 21;18(12):2907-2917. doi: 10.1016/j.celrep.2017.02.073.


Biphasic regulation of A20 gene expression during human cytomegalovirus infection.

Gu SY, Kim YE, Kwon KM, Han TH, Ahn JH.

Virol J. 2014 Jul 8;11:124. doi: 10.1186/1743-422X-11-124.


Two gamma interferon-activated site-like elements in the human cytomegalovirus major immediate-early promoter/enhancer are important for viral replication.

Netterwald J, Yang S, Wang W, Ghanny S, Cody M, Soteropoulos P, Tian B, Dunn W, Liu F, Zhu H.

J Virol. 2005 Apr;79(8):5035-46.

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