Format
Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 131

1.

Rational design of berberine-based FtsZ inhibitors with broad-spectrum antibacterial activity.

Sun N, Chan FY, Lu YJ, Neves MA, Lui HK, Wang Y, Chow KY, Chan KF, Yan SC, Leung YC, Abagyan R, Chan TH, Wong KY.

PLoS One. 2014 May 13;9(5):e97514. doi: 10.1371/journal.pone.0097514. eCollection 2014.

2.

Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria.

Keffer JL, Huecas S, Hammill JT, Wipf P, Andreu JM, Bewley CA.

Bioorg Med Chem. 2013 Sep 15;21(18):5673-8. doi: 10.1016/j.bmc.2013.07.033. Epub 2013 Jul 25.

3.

Genetic evidence for inhibition of bacterial division protein FtsZ by berberine.

Boberek JM, Stach J, Good L.

PLoS One. 2010 Oct 29;5(10):e13745. doi: 10.1371/journal.pone.0013745.

4.

Antimicrobial activity of a quinuclidine-based FtsZ inhibitor and its synergistic potential with β-lactam antibiotics.

Chan FY, Sun N, Leung YC, Wong KY.

J Antibiot (Tokyo). 2015 Apr;68(4):253-8. doi: 10.1038/ja.2014.140. Epub 2014 Oct 8.

PMID:
25293977
5.

Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ.

Plaza A, Keffer JL, Bifulco G, Lloyd JR, Bewley CA.

J Am Chem Soc. 2010 Jul 7;132(26):9069-77. doi: 10.1021/ja102100h.

6.

Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity.

Rai D, Singh JK, Roy N, Panda D.

Biochem J. 2008 Feb 15;410(1):147-55.

PMID:
17953519
7.

Inhibition of RND-type efflux pumps confers the FtsZ-directed prodrug TXY436 with activity against Gram-negative bacteria.

Kaul M, Zhang Y, Parhi AK, Lavoie EJ, Pilch DS.

Biochem Pharmacol. 2014 Jun 1;89(3):321-8. doi: 10.1016/j.bcp.2014.03.002. Epub 2014 Mar 14.

PMID:
24637241
8.

Synthesis and antibacterial activity of novel 4-bromo-1H-indazole derivatives as FtsZ inhibitors.

Wang Y, Yan M, Ma R, Ma S.

Arch Pharm (Weinheim). 2015 Apr;348(4):266-74. doi: 10.1002/ardp.201400412. Epub 2015 Mar 13.

PMID:
25773717
9.

Characterization and in vitro inhibition studies of Bacillus anthracis FtsZ: a potential antibacterial target.

Park HC, Gedi V, Cho JH, Hyun JW, Lee KJ, Kang J, So B, Yoon MY.

Appl Biochem Biotechnol. 2014 Mar;172(6):3263-70. doi: 10.1007/s12010-014-0752-2. Epub 2014 Feb 9.

PMID:
24510482
10.

Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics.

Wang J, Galgoci A, Kodali S, Herath KB, Jayasuriya H, Dorso K, Vicente F, González A, Cully D, Bramhill D, Singh S.

J Biol Chem. 2003 Nov 7;278(45):44424-8. Epub 2003 Sep 2.

11.

Plumbagin inhibits cytokinesis in Bacillus subtilis by inhibiting FtsZ assembly--a mechanistic study of its antibacterial activity.

Bhattacharya A, Jindal B, Singh P, Datta A, Panda D.

FEBS J. 2013 Sep;280(18):4585-99. doi: 10.1111/febs.12429. Epub 2013 Aug 2.

12.

Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.

Parhi A, Lu S, Kelley C, Kaul M, Pilch DS, LaVoie EJ.

Bioorg Med Chem Lett. 2012 Nov 15;22(22):6962-6. doi: 10.1016/j.bmcl.2012.08.123. Epub 2012 Sep 20.

13.

Berberine targets assembly of Escherichia coli cell division protein FtsZ.

Domadia PN, Bhunia A, Sivaraman J, Swarup S, Dasgupta D.

Biochemistry. 2008 Mar 11;47(10):3225-34. doi: 10.1021/bi7018546. Epub 2008 Feb 15.

PMID:
18275156
14.

Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality.

Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D.

Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11821-6. Epub 2004 Aug 2. Erratum in: Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13969.

15.

Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of action.

Artola M, Ruiz-Avila LB, Vergoñós A, Huecas S, Araujo-Bazán L, Martín-Fontecha M, Vázquez-Villa H, Turrado C, Ramírez-Aportela E, Hoegl A, Nodwell M, Barasoain I, Chacón P, Sieber SA, Andreu JM, López-Rodríguez ML.

ACS Chem Biol. 2015 Mar 20;10(3):834-43. doi: 10.1021/cb500974d. Epub 2014 Dec 30.

PMID:
25486266
16.

An improved small-molecule inhibitor of FtsZ with superior in vitro potency, drug-like properties, and in vivo efficacy.

Stokes NR, Baker N, Bennett JM, Berry J, Collins I, Czaplewski LG, Logan A, Macdonald R, Macleod L, Peasley H, Mitchell JP, Nayal N, Yadav A, Srivastava A, Haydon DJ.

Antimicrob Agents Chemother. 2013 Jan;57(1):317-25. doi: 10.1128/AAC.01580-12. Epub 2012 Oct 31.

17.

BT-benzo-29 inhibits bacterial cell proliferation by perturbing FtsZ assembly.

Ray S, Jindal B, Kunal K, Surolia A, Panda D.

FEBS J. 2015 Oct;282(20):4015-33. doi: 10.1111/febs.13403. Epub 2015 Sep 18.

PMID:
26258635
18.

Design, synthesis and structure-activity relationships of substituted oxazole-benzamide antibacterial inhibitors of FtsZ.

Stokes NR, Baker N, Bennett JM, Chauhan PK, Collins I, Davies DT, Gavade M, Kumar D, Lancett P, Macdonald R, Macleod L, Mahajan A, Mitchell JP, Nayal N, Nayal YN, Pitt GR, Singh M, Yadav A, Srivastava A, Czaplewski LG, Haydon DJ.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):353-9. doi: 10.1016/j.bmcl.2013.11.002. Epub 2013 Nov 13.

PMID:
24287381
19.

Identification of a new class of FtsZ inhibitors by structure-based design and in vitro screening.

Chan FY, Sun N, Neves MA, Lam PC, Chung WH, Wong LK, Chow HY, Ma DL, Chan PH, Leung YC, Chan TH, Abagyan R, Wong KY.

J Chem Inf Model. 2013 Aug 26;53(8):2131-40. doi: 10.1021/ci400203f. Epub 2013 Jul 25.

PMID:
23848971
20.

A combined CoMFA and CoMSIA 3D-QSAR study of benzamide type antibacterial inhibitors of the FtsZ protein in drug-resistant Staphylococcus aureus.

Andrades J, Campanini J, Vásquez D, Silvestri C, Morales C, Romero J, Mella J.

SAR QSAR Environ Res. 2015;26(11):925-42. doi: 10.1080/1062936X.2015.1095798. Epub 2015 Oct 27.

PMID:
26505124
Items per page

Supplemental Content

Write to the Help Desk