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Items: 1 to 20 of 94

1.

Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.

Jiang H, He P, Xie J, Staufenbiel M, Li R, Shen Y.

Hum Mol Genet. 2014 Sep 15;23(18):4906-18. doi: 10.1093/hmg/ddu206. Epub 2014 May 13.

2.

Deletion of tumor necrosis factor death receptor inhibits amyloid beta generation and prevents learning and memory deficits in Alzheimer's mice.

He P, Zhong Z, Lindholm K, Berning L, Lee W, Lemere C, Staufenbiel M, Li R, Shen Y.

J Cell Biol. 2007 Aug 27;178(5):829-41.

3.

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

Chen CH, Zhou W, Liu S, Deng Y, Cai F, Tone M, Tone Y, Tong Y, Song W.

Int J Neuropsychopharmacol. 2012 Feb;15(1):77-90. doi: 10.1017/S1461145711000149. Epub 2011 Feb 18.

PMID:
21329555
4.

Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.

Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M.

Neurobiol Dis. 2016 Jan;85:187-205. doi: 10.1016/j.nbd.2015.11.005. Epub 2015 Nov 10.

PMID:
26563932
5.

BACE1 elevation is involved in amyloid plaque development in the triple transgenic model of Alzheimer's disease: differential Aβ antibody labeling of early-onset axon terminal pathology.

Cai Y, Zhang XM, Macklin LN, Cai H, Luo XG, Oddo S, Laferla FM, Struble RG, Rose GM, Patrylo PR, Yan XX.

Neurotox Res. 2012 Feb;21(2):160-74. doi: 10.1007/s12640-011-9256-9. Epub 2011 Jul 2.

6.

Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer's disease.

He P, Cheng X, Staufenbiel M, Li R, Shen Y.

PLoS One. 2013;8(2):e55091. doi: 10.1371/journal.pone.0055091. Epub 2013 Feb 6.

7.

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.

Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R.

PLoS One. 2014 Jul 3;9(7):e101643. doi: 10.1371/journal.pone.0101643. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e110914.

8.

Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.

PMID:
23773065
9.

Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment.

McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R.

J Neurosci. 2010 May 26;30(21):7326-34. doi: 10.1523/JNEUROSCI.1180-10.2010.

10.

Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level.

Sadleir KR, Eimer WA, Cole SL, Vassar R.

Mol Neurodegener. 2015 Jan 7;10:1. doi: 10.1186/1750-1326-10-1.

11.

Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells.

Marwarha G, Raza S, Prasanthi JR, Ghribi O.

PLoS One. 2013 Aug 9;8(8):e70773. doi: 10.1371/journal.pone.0070773. eCollection 2013.

12.

A combination Alzheimer's therapy targeting BACE1 and neprilysin in 5XFAD transgenic mice.

Devi L, Ohno M.

Mol Brain. 2015 Mar 25;8:19. doi: 10.1186/s13041-015-0110-5.

13.

Systemic administration of fibroblast growth factor-2 (FGF2) reduces BACE1 expression and amyloid pathology in APP23 mice.

Katsouri L, Ashraf A, Birch AM, Lee KK, Mirzaei N, Sastre M.

Neurobiol Aging. 2015 Feb;36(2):821-31. doi: 10.1016/j.neurobiolaging.2014.10.004. Epub 2014 Oct 13.

PMID:
25457554
14.

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice.

McConlogue L, Buttini M, Anderson JP, Brigham EF, Chen KS, Freedman SB, Games D, Johnson-Wood K, Lee M, Zeller M, Liu W, Motter R, Sinha S.

J Biol Chem. 2007 Sep 7;282(36):26326-34. Epub 2007 Jul 6.

15.

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.

Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT.

J Biol Chem. 2004 Dec 10;279(50):52535-42. Epub 2004 Sep 27.

16.

Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development.

Zhang XM, Cai Y, Xiong K, Cai H, Luo XG, Feng JC, Clough RW, Struble RG, Patrylo PR, Yan XX.

Eur J Neurosci. 2009 Dec;30(12):2271-83. doi: 10.1111/j.1460-9568.2009.07017.x. Epub 2009 Dec 10.

17.

Calpain activation promotes BACE1 expression, amyloid precursor protein processing, and amyloid plaque formation in a transgenic mouse model of Alzheimer disease.

Liang B, Duan BY, Zhou XP, Gong JX, Luo ZG.

J Biol Chem. 2010 Sep 3;285(36):27737-44. doi: 10.1074/jbc.M110.117960. Epub 2010 Jul 1.

18.
19.

NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.

20.

Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis.

O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, Vassar R.

Neuron. 2008 Dec 26;60(6):988-1009. doi: 10.1016/j.neuron.2008.10.047.

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