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Items: 1 to 20 of 184

1.

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S.

Hum Mol Genet. 2014 Oct 1;23(19):5052-60. doi: 10.1093/hmg/ddu217. Epub 2014 May 12.

PMID:
24821705
2.

WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.

Susa K, Sohara E, Takahashi D, Okado T, Rai T, Uchida S.

Biochem Biophys Res Commun. 2017 Sep 23;491(3):727-732. doi: 10.1016/j.bbrc.2017.07.121. Epub 2017 Jul 22.

PMID:
28743496
3.

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.

4.

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension.

Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S.

Cell Rep. 2013 Mar 28;3(3):858-68. doi: 10.1016/j.celrep.2013.02.024. Epub 2013 Feb 28.

5.

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.

Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7838-43. doi: 10.1073/pnas.1304592110. Epub 2013 Apr 1.

6.

KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.

Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00508-16. doi: 10.1128/MCB.00508-16. Print 2017 Apr 1.

7.

Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.

Sohara E, Uchida S.

Nephrol Dial Transplant. 2016 Sep;31(9):1417-24. doi: 10.1093/ndt/gfv259. Epub 2015 Jul 6. Review.

PMID:
26152401
8.

Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.

Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2013 Sep 13;439(1):30-4. doi: 10.1016/j.bbrc.2013.08.035. Epub 2013 Aug 17.

PMID:
23962426
9.

Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice.

Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E.

Biochem Biophys Res Commun. 2017 May 27;487(2):368-374. doi: 10.1016/j.bbrc.2017.04.068. Epub 2017 Apr 14.

PMID:
28414128
10.

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S.

J Cell Sci. 2011 May 1;124(Pt 9):1391-5. doi: 10.1242/jcs.084111. Epub 2011 Apr 12.

11.

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation.

Wu G, Peng JB.

FEBS Lett. 2013 Jun 19;587(12):1717-22. doi: 10.1016/j.febslet.2013.04.032. Epub 2013 May 9.

12.

KLHL2 interacts with and ubiquitinates WNK kinases.

Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.

Biochem Biophys Res Commun. 2013 Aug 2;437(3):457-62. doi: 10.1016/j.bbrc.2013.06.104. Epub 2013 Jul 6.

PMID:
23838290
13.

ROMK expression remains unaltered in a mouse model of familial hyperkalemic hypertension caused by the CUL3Δ403-459 mutation.

Murthy M, Kurz T, O'Shaughnessy KM.

Physiol Rep. 2016 Jul;4(13). pii: e12850. doi: 10.14814/phy2.12850.

14.

WNK kinases regulate thiazide-sensitive Na-Cl cotransport.

Yang CL, Angell J, Mitchell R, Ellison DH.

J Clin Invest. 2003 Apr;111(7):1039-45.

15.

Potassium depletion stimulates Na-Cl cotransporter via phosphorylation and inactivation of the ubiquitin ligase Kelch-like 3.

Ishizawa K, Xu N, Loffing J, Lifton RP, Fujita T, Uchida S, Shibata S.

Biochem Biophys Res Commun. 2016 Nov;480(4):745-751. doi: 10.1016/j.bbrc.2016.10.127. Epub 2016 Oct 29.

16.

SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.

Chu PY, Cheng CJ, Wu YC, Fang YW, Chau T, Uchida S, Sasaki S, Yang SS, Lin SH.

PLoS One. 2013 Sep 11;8(9):e72969. doi: 10.1371/journal.pone.0072969. eCollection 2013.

17.

Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.

Zhang C, Meermeier NP, Terker AS, Blankenstein KI, Singer JD, Hadchouel J, Ellison DH, Yang CL.

Biochem Biophys Res Commun. 2016 Jan 1;469(1):44-48. doi: 10.1016/j.bbrc.2015.11.067. Epub 2015 Nov 23.

18.

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.

Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S.

Cell Metab. 2007 May;5(5):331-44.

19.

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.

Chávez-Canales M, Zhang C, Soukaseum C, Moreno E, Pacheco-Alvarez D, Vidal-Petiot E, Castañeda-Bueno M, Vázquez N, Rojas-Vega L, Meermeier NP, Rogers S, Jeunemaitre X, Yang CL, Ellison DH, Gamba G, Hadchouel J.

Hypertension. 2014 Nov;64(5):1047-53. doi: 10.1161/HYPERTENSIONAHA.114.04036. Epub 2014 Aug 11.

20.

Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL3.

Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.

Biochem Biophys Res Commun. 2015 Nov 13;467(2):229-34. doi: 10.1016/j.bbrc.2015.09.184. Epub 2015 Oct 3.

PMID:
26435498

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