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Items: 1 to 20 of 114

1.

Narrowing the gap between the promise and reality of polyketide synthases as a synthetic biology platform.

Poust S, Hagen A, Katz L, Keasling JD.

Curr Opin Biotechnol. 2014 Dec;30:32-9. doi: 10.1016/j.copbio.2014.04.011. Epub 2014 May 6. Review.

PMID:
24816568
2.

Heterologous production of polyketides by modular type I polyketide synthases in Escherichia coli.

Yuzawa S, Kim W, Katz L, Keasling JD.

Curr Opin Biotechnol. 2012 Oct;23(5):727-35. doi: 10.1016/j.copbio.2011.12.029. Epub 2012 Jan 13. Review.

PMID:
22244790
3.

Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes.

Menzella HG, Reid R, Carney JR, Chandran SS, Reisinger SJ, Patel KG, Hopwood DA, Santi DV.

Nat Biotechnol. 2005 Sep;23(9):1171-6. Epub 2005 Aug 14.

PMID:
16116420
4.

Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future.

Stewart C Jr, Vickery CR, Burkart MD, Noel JP.

Curr Opin Plant Biol. 2013 Jun;16(3):365-72. doi: 10.1016/j.pbi.2013.02.004. Epub 2013 Mar 5. Review.

PMID:
23481348
5.

Comprehensive in Vitro Analysis of Acyltransferase Domain Exchanges in Modular Polyketide Synthases and Its Application for Short-Chain Ketone Production.

Yuzawa S, Deng K, Wang G, Baidoo EE, Northen TR, Adams PD, Katz L, Keasling JD.

ACS Synth Biol. 2017 Jan 20;6(1):139-147. doi: 10.1021/acssynbio.6b00176. Epub 2016 Sep 6.

PMID:
27548700
6.

Engineering a Polyketide Synthase for In Vitro Production of Adipic Acid.

Hagen A, Poust S, Rond Td, Fortman JL, Katz L, Petzold CJ, Keasling JD.

ACS Synth Biol. 2016 Jan 15;5(1):21-7. doi: 10.1021/acssynbio.5b00153. Epub 2015 Nov 10.

PMID:
26501439
7.

Using chemobiosynthesis and synthetic mini-polyketide synthases to produce pharmaceutical intermediates in Escherichia coli.

Menzella HG, Carney JR, Li Y, Santi DV.

Appl Environ Microbiol. 2010 Aug;76(15):5221-7. doi: 10.1128/AEM.02961-09. Epub 2010 Jun 11.

8.

Rational design and assembly of synthetic trimodular polyketide synthases.

Menzella HG, Carney JR, Santi DV.

Chem Biol. 2007 Feb;14(2):143-51.

9.
10.

Developing tools for engineering hybrid polyketide synthetic pathways.

Kittendorf JD, Sherman DH.

Curr Opin Biotechnol. 2006 Dec;17(6):597-605. Epub 2006 Oct 12. Review.

PMID:
17046237
11.

Progress challenges and opportunities for the re-engineering of trans-AT polyketide synthases.

Till M, Race PR.

Biotechnol Lett. 2014 May;36(5):877-88. doi: 10.1007/s10529-013-1449-2. Epub 2014 Feb 21. Review.

PMID:
24557077
12.

Towards prediction of metabolic products of polyketide synthases: an in silico analysis.

Yadav G, Gokhale RS, Mohanty D.

PLoS Comput Biol. 2009 Apr;5(4):e1000351. doi: 10.1371/journal.pcbi.1000351. Epub 2009 Apr 10.

13.

Functional analysis of the aureothin iterative type I polyketide synthase.

He J, Hertweck C.

Chembiochem. 2005 May;6(5):908-12.

PMID:
15812854
14.

ASMPKS: an analysis system for modular polyketide synthases.

Tae H, Kong EB, Park K.

BMC Bioinformatics. 2007 Sep 3;8:327.

15.

Engineered polyketide biosynthesis and biocatalysis in Escherichia coli.

Gao X, Wang P, Tang Y.

Appl Microbiol Biotechnol. 2010 Dec;88(6):1233-42. doi: 10.1007/s00253-010-2860-4. Epub 2010 Sep 19. Review.

16.

Insights into multienzyme docking in hybrid PKS-NRPS megasynthetases revealed by heterologous expression and genetic engineering.

Li Y, Weissman KJ, Müller R.

Chembiochem. 2010 May 17;11(8):1069-75. doi: 10.1002/cbic.201000103. No abstract available.

PMID:
20391455
17.

Computational identification and analysis of orphan assembly-line polyketide synthases.

O'Brien RV, Davis RW, Khosla C, Hillenmeyer ME.

J Antibiot (Tokyo). 2014 Jan;67(1):89-97. doi: 10.1038/ja.2013.125. Epub 2013 Dec 4.

18.

Modular construction of a functional artificial epothilone polyketide pathway.

Osswald C, Zipf G, Schmidt G, Maier J, Bernauer HS, Müller R, Wenzel SC.

ACS Synth Biol. 2014 Oct 17;3(10):759-72. doi: 10.1021/sb300080t. Epub 2012 Nov 5.

PMID:
23654254
19.

Mutagenesis of a modular polyketide synthase enoylreductase domain reveals insights into catalysis and stereospecificity.

Kwan DH, Leadlay PF.

ACS Chem Biol. 2010 Sep 17;5(9):829-38. doi: 10.1021/cb100175a.

PMID:
20666435
20.

Rational design of macrolides by virtual screening of combinatorial libraries generated through in silico manipulation of polyketide synthases.

Zotchev SB, Stepanchikova AV, Sergeyko AP, Sobolev BN, Filimonov DA, Poroikov VV.

J Med Chem. 2006 Mar 23;49(6):2077-87.

PMID:
16539396

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