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Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma.

Attar-Schneider O, Drucker L, Zismanov V, Tartakover-Matalon S, Lishner M.

Cell Signal. 2014 Sep;26(9):1878-87. doi: 10.1016/j.cellsig.2014.05.005. Epub 2014 May 9.


NAD(P)H quinone-oxydoreductase 1 protects eukaryotic translation initiation factor 4GI from degradation by the proteasome.

Alard A, Fabre B, Anesia R, Marboeuf C, Pierre P, Susini C, Bousquet C, Pyronnet S.

Mol Cell Biol. 2010 Feb;30(4):1097-105. doi: 10.1128/MCB.00868-09. Epub 2009 Dec 22.


Migration and epithelial-to-mesenchymal transition of lung cancer can be targeted via translation initiation factors eIF4E and eIF4GI.

Attar-Schneider O, Drucker L, Gottfried M.

Lab Invest. 2016 Sep;96(9):1004-15. doi: 10.1038/labinvest.2016.77. Epub 2016 Aug 8.


Bevacizumab attenuates major signaling cascades and eIF4E translation initiation factor in multiple myeloma cells.

Attar-Schneider O, Drucker L, Zismanov V, Tartakover-Matalon S, Rashid G, Lishner M.

Lab Invest. 2012 Feb;92(2):178-90. doi: 10.1038/labinvest.2011.162. Epub 2011 Nov 14.


eIF4E and eIF4GI have distinct and differential imprints on multiple myeloma's proteome and signaling.

Attar-Schneider O, Pasmanik-Chor M, Tartakover-Matalon S, Drucker L, Lishner M.

Oncotarget. 2015 Feb 28;6(6):4315-29.


Multiple myeloma cells promote migration of bone marrow mesenchymal stem cells by altering their translation initiation.

Dabbah M, Attar-Schneider O, Zismanov V, Tartakover Matalon S, Lishner M, Drucker L.

J Leukoc Biol. 2016 Oct;100(4):761-770. Epub 2016 Jun 6.


Multiple myeloma and bone marrow mesenchymal stem cells' crosstalk: Effect on translation initiation.

Attar-Schneider O, Zismanov V, Dabbah M, Tartakover-Matalon S, Drucker L, Lishner M.

Mol Carcinog. 2016 Sep;55(9):1343-54. doi: 10.1002/mc.22378. Epub 2015 Aug 21.


The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction.

Descamps G, Gomez-Bougie P, Tamburini J, Green A, Bouscary D, Maïga S, Moreau P, Le Gouill S, Pellat-Deceunynck C, Amiot M.

Br J Cancer. 2012 May 8;106(10):1660-7. doi: 10.1038/bjc.2012.139. Epub 2012 Apr 17.


Mesenchymal stem cells secretomes' affect multiple myeloma translation initiation.

Marcus H, Attar-Schneider O, Dabbah M, Zismanov V, Tartakover-Matalon S, Lishner M, Drucker L.

Cell Signal. 2016 Jun;28(6):620-30. doi: 10.1016/j.cellsig.2016.03.003. Epub 2016 Mar 11.


Specific isoforms of translation initiation factor 4GI show differences in translational activity.

Coldwell MJ, Morley SJ.

Mol Cell Biol. 2006 Nov;26(22):8448-60. Epub 2006 Sep 18.


SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G.

Chen LZ, Li XY, Huang H, Xing W, Guo W, He J, Sun ZY, Luo AX, Liang HP, Hu J, Wang ZG, Xu YS, Xu X.

PLoS One. 2014 Jun 27;9(6):e100457. doi: 10.1371/journal.pone.0100457. eCollection 2014. Erratum in: PLoS One. 2014;9(9):e108832.


Translation of mRNAs from vesicular stomatitis virus and vaccinia virus is differentially blocked in cells with depletion of eIF4GI and/or eIF4GII.

Welnowska E, Castelló A, Moral P, Carrasco L.

J Mol Biol. 2009 Dec 4;394(3):506-21. doi: 10.1016/j.jmb.2009.09.036. Epub 2009 Sep 19.


Equol, an isoflavone metabolite, regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF4G.

de la Parra C, Borrero-Garcia LD, Cruz-Collazo A, Schneider RJ, Dharmawardhane S.

J Biol Chem. 2015 Mar 6;290(10):6047-57. doi: 10.1074/jbc.M114.617415. Epub 2015 Jan 15.


Elevated Translation Initiation Factor eIF4E Is an Attractive Therapeutic Target in Multiple Myeloma.

Li S, Fu J, Lu C, Mapara MY, Raza S, Hengst U, Lentzsch S.

Mol Cancer Ther. 2016 Apr;15(4):711-9. doi: 10.1158/1535-7163.MCT-15-0798. Epub 2016 Mar 3.

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