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Items: 1 to 20 of 132

1.

Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity.

Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid T, Guedes RC, dos Santos DJ, Rosenthal PJ, Moreira R.

Eur J Med Chem. 2014 Jun 10;80:523-34. doi: 10.1016/j.ejmech.2014.04.076. Epub 2014 Apr 28.

PMID:
24813880
2.

In vitro activity of aurones against Plasmodium falciparum strains K1 and NF54.

Kayser O, Kiderlen AF, Brun R.

Planta Med. 2001 Nov;67(8):718-21.

PMID:
11731912
3.

1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs.

Souard F, Okombi S, Beney C, Chevalley S, Valentin A, Boumendjel A.

Bioorg Med Chem. 2010 Aug 1;18(15):5724-31. doi: 10.1016/j.bmc.2010.06.008. Epub 2010 Jun 9.

PMID:
20630767
4.

Design, economical synthesis and antiplasmodial evaluation of vanillin derived allylated chalcones and their marked synergism with artemisinin against chloroquine resistant strains of Plasmodium falciparum.

Sharma N, Mohanakrishnan D, Sharma UK, Kumar R, Richa, Sinha AK, Sahal D.

Eur J Med Chem. 2014 May 22;79:350-68. doi: 10.1016/j.ejmech.2014.03.079. Epub 2014 Apr 1.

PMID:
24747290
5.

Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials.

Praveen Kumar S, Gut J, Guedes RC, Rosenthal PJ, Santos MM, Moreira R.

Eur J Med Chem. 2011 Mar;46(3):927-33. doi: 10.1016/j.ejmech.2011.01.008. Epub 2011 Jan 15.

PMID:
21295887
6.

N-cinnamoylation of antimalarial classics: quinacrine analogues with decreased toxicity and dual-stage activity.

Gomes A, Pérez B, Albuquerque I, Machado M, Prudêncio M, Nogueira F, Teixeira C, Gomes P.

ChemMedChem. 2014 Feb;9(2):305-10. doi: 10.1002/cmdc.201300459. Epub 2013 Dec 27.

PMID:
24474655
7.

Indolone-N-oxide derivatives: in vitro activity against fresh clinical isolates of Plasmodium falciparum, stage specificity and in vitro interactions with established antimalarial drugs.

Tahar R, Vivas L, Basco L, Thompson E, Ibrahim H, Boyer J, Nepveu F.

J Antimicrob Chemother. 2011 Nov;66(11):2566-72. doi: 10.1093/jac/dkr320. Epub 2011 Aug 22.

PMID:
21862474
8.

Synthesis and in vitro evaluation of new chloroquine-chalcone hybrids against chloroquine-resistant strain of Plasmodium falciparum.

Sashidhara KV, Avula SR, Palnati GR, Singh SV, Srivastava K, Puri SK, Saxena JK.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5455-9. doi: 10.1016/j.bmcl.2012.07.028. Epub 2012 Jul 14.

PMID:
22850213
9.

Synthetic indole and melatonin derivatives exhibit antimalarial activity on the cell cycle of the human malaria parasite Plasmodium falciparum.

Schuck DC, Jordão AK, Nakabashi M, Cunha AC, Ferreira VF, Garcia CR.

Eur J Med Chem. 2014 May 6;78:375-82. doi: 10.1016/j.ejmech.2014.03.055. Epub 2014 Mar 18.

PMID:
24699367
10.

Microwave-assisted ring opening of epoxides: a general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities.

Robin A, Brown F, Bahamontes-Rosa N, Wu B, Beitz E, Kun JF, Flitsch SL.

J Med Chem. 2007 Aug 23;50(17):4243-9. Epub 2007 Aug 1.

PMID:
17665900
11.

Aminonaphthoquinones--a novel class of compounds with potent antimalarial activity against Plasmodium falciparum.

Kapadia GJ, Azuine MA, Balasubramanian V, Sridhar R.

Pharmacol Res. 2001 Apr;43(4):363-7.

PMID:
11352541
12.

Synthesis, in vitro antimalarial activity and cytotoxicity of novel 4-aminoquinolinyl-chalcone amides.

Smit FJ, N'da DD.

Bioorg Med Chem. 2014 Feb 1;22(3):1128-38. doi: 10.1016/j.bmc.2013.12.032. Epub 2013 Dec 22.

PMID:
24411478
13.

Evaluation of substituted phenalenone analogues as antiplasmodial agents.

Gutiérrez D, Flores N, Abad-Grillo T, McNaughton-Smith G.

Exp Parasitol. 2013 Oct;135(2):456-8. doi: 10.1016/j.exppara.2013.08.008. Epub 2013 Aug 25.

PMID:
23985373
14.

Design, synthesis, and evaluation of 10-N-substituted acridones as novel chemosensitizers in Plasmodium falciparum.

Kelly JX, Smilkstein MJ, Cooper RA, Lane KD, Johnson RA, Janowsky A, Dodean RA, Hinrichs DJ, Winter R, Riscoe M.

Antimicrob Agents Chemother. 2007 Nov;51(11):4133-40. Epub 2007 Sep 10.

15.

Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity.

Clarkson C, Musonda CC, Chibale K, Campbell WE, Smith P.

Bioorg Med Chem. 2003 Oct 1;11(20):4417-22.

PMID:
13129578
16.

Synthesis, structural characterization and biological evaluation of novel stilbene derivatives as potential antimalarial agents.

Jung M, Park WH, Jung JC, Lim E, Lee Y, Oh S, Moon HI.

Chem Biol Drug Des. 2009 Mar;73(3):346-54. doi: 10.1111/j.1747-0285.2009.00775.x.

PMID:
19207471
17.

Targeting the human malaria parasite Plasmodium falciparum: in vitro identification of a new antiplasmodial hit in 4-phenoxy-2-trichloromethylquinazoline series.

Castera-Ducros C, Azas N, Verhaeghe P, Hutter S, Garrigue P, Dumètre A, Mbatchi L, Laget M, Remusat V, Sifredi F, Rault S, Rathelot P, Vanelle P.

Eur J Med Chem. 2011 Sep;46(9):4184-91. doi: 10.1016/j.ejmech.2011.06.021. Epub 2011 Jun 23.

PMID:
21741131
18.

3,5-bis(benzylidene)-4-piperidones and related N-acyl analogs: a novel cluster of antimalarials targeting the liver stage of Plasmodium falciparum.

Das U, Singh RS, Alcorn J, Hickman MR, Sciotti RJ, Leed SE, Lee PJ, Roncal N, Dimmock JR.

Bioorg Med Chem. 2013 Dec 1;21(23):7250-6. doi: 10.1016/j.bmc.2013.09.065. Epub 2013 Oct 8.

PMID:
24139941
19.

Ligand based validated comparative chemometric modeling and pharmacophore mapping of aurone derivatives as antimalarial agents.

Adhikari N, Halder AK, Mondal C, Jha T.

Curr Comput Aided Drug Des. 2013 Sep;9(3):417-32.

PMID:
24010937
20.

Synthesis and antimalarial activity of new atovaquone derivatives.

El Hage S, Ane M, Stigliani JL, Marjorie M, Vial H, Baziard-Mouysset G, Payard M.

Eur J Med Chem. 2009 Nov;44(11):4778-82. doi: 10.1016/j.ejmech.2009.07.021. Epub 2009 Jul 30.

PMID:
19747753

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