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Items: 1 to 20 of 110

1.

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility.

Cruz-Orengo L, Daniels BP, Dorsey D, Basak SA, Grajales-Reyes JG, McCandless EE, Piccio L, Schmidt RE, Cross AH, Crosby SD, Klein RS.

J Clin Invest. 2014 Jun;124(6):2571-84. doi: 10.1172/JCI73408. Epub 2014 May 8.

2.

A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression.

Yue X, Jin H, Liu H, Rosenberg AJ, Klein RS, Tu Z.

Org Biomol Chem. 2015 Aug 7;13(29):7928-39. doi: 10.1039/c5ob00951k. Epub 2015 Jun 25.

3.

Blockade of the kinin receptor B1 protects from autoimmune CNS disease by reducing leukocyte trafficking.

Göbel K, Pankratz S, Schneider-Hohendorf T, Bittner S, Schuhmann MK, Langer HF, Stoll G, Wiendl H, Kleinschnitz C, Meuth SG.

J Autoimmun. 2011 Mar;36(2):106-14. doi: 10.1016/j.jaut.2010.11.004. Epub 2011 Jan 8.

PMID:
21216565
4.

IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis.

McCandless EE, Budde M, Lees JR, Dorsey D, Lyng E, Klein RS.

J Immunol. 2009 Jul 1;183(1):613-20. doi: 10.4049/jimmunol.0802258. Epub 2009 Jun 17.

5.
6.

Identification of genetic determinants of the sexual dimorphism in CNS autoimmunity.

Bearoff F, Case LK, Krementsov DN, Wall EH, Saligrama N, Blankenhorn EP, Teuscher C.

PLoS One. 2015 Feb 11;10(2):e0117993. doi: 10.1371/journal.pone.0117993. eCollection 2015.

7.

Endothelial histamine H1 receptor signaling reduces blood-brain barrier permeability and susceptibility to autoimmune encephalomyelitis.

Lu C, Diehl SA, Noubade R, Ledoux J, Nelson MT, Spach K, Zachary JF, Blankenhorn EP, Teuscher C.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18967-72. doi: 10.1073/pnas.1008816107. Epub 2010 Oct 18.

8.

Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice.

Cui H, Okamoto Y, Yoshioka K, Du W, Takuwa N, Zhang W, Asano M, Shibamoto T, Takuwa Y.

J Allergy Clin Immunol. 2013 Nov;132(5):1205-1214.e9. doi: 10.1016/j.jaci.2013.07.026. Epub 2013 Sep 8.

PMID:
24021572
9.

Blood-brain barrier changes and cell invasion differ between therapeutic immune clearance of neurotrophic virus and CNS autoimmunity.

Fabis MJ, Phares TW, Kean RB, Koprowski H, Hooper DC.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15511-6. doi: 10.1073/pnas.0807656105. Epub 2008 Sep 30.

10.

FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation.

Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):751-6. doi: 10.1073/pnas.1014154108. Epub 2010 Dec 21.

11.

Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.

Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH.

Nat Immunol. 2013 Nov;14(11):1166-72. doi: 10.1038/ni.2730. Epub 2013 Sep 29.

12.

Exacerbation of autoimmune neuroinflammation by dietary sodium is genetically controlled and sex specific.

Krementsov DN, Case LK, Hickey WF, Teuscher C.

FASEB J. 2015 Aug;29(8):3446-57. doi: 10.1096/fj.15-272542. Epub 2015 Apr 27.

13.

Inhibition of hyaluronan synthesis protects against central nervous system (CNS) autoimmunity and increases CXCL12 expression in the inflamed CNS.

Mueller AM, Yoon BH, Sadiq SA.

J Biol Chem. 2014 Aug 15;289(33):22888-99. doi: 10.1074/jbc.M114.559583. Epub 2014 Jun 27.

14.

DARC shuttles inflammatory chemokines across the blood-brain barrier during autoimmune central nervous system inflammation.

Minten C, Alt C, Gentner M, Frei E, Deutsch U, Lyck R, Schaeren-Wiemers N, Rot A, Engelhardt B.

Brain. 2014 May;137(Pt 5):1454-69. doi: 10.1093/brain/awu045. Epub 2014 Mar 12.

15.

Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility.

Krementsov DN, Wall EH, Martin RA, Subramanian M, Noubade R, Del Rio R, Mawe GM, Bond JP, Poynter ME, Blankenhorn EP, Teuscher C.

PLoS One. 2013 Jul 22;8(7):e62743. doi: 10.1371/journal.pone.0062743. Print 2013.

16.

Sphingosine 1-phosphate Receptor 2 Signaling Suppresses Macrophage Phagocytosis and Impairs Host Defense against Sepsis.

Hou J, Chen Q, Zhang K, Cheng B, Xie G, Wu X, Luo C, Chen L, Liu H, Zhao B, Dai K, Fang X.

Anesthesiology. 2015 Aug;123(2):409-22. doi: 10.1097/ALN.0000000000000725.

PMID:
26200183
17.

B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity.

Klotz L, Kuzmanov I, Hucke S, Gross CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth SG, Kuhlmann T, Wiendl H.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):E6182-E6191. Epub 2016 Sep 26.

18.

Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis.

Pfeiffer F, Schäfer J, Lyck R, Makrides V, Brunner S, Schaeren-Wiemers N, Deutsch U, Engelhardt B.

Acta Neuropathol. 2011 Nov;122(5):601-14. doi: 10.1007/s00401-011-0883-2. Epub 2011 Oct 9.

19.

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice.

Wang F, Okamoto Y, Inoki I, Yoshioka K, Du W, Qi X, Takuwa N, Gonda K, Yamamoto Y, Ohkawa R, Nishiuchi T, Sugimoto N, Yatomi Y, Mitsumori K, Asano M, Kinoshita M, Takuwa Y.

J Clin Invest. 2010 Nov;120(11):3979-95. doi: 10.1172/JCI42315. Epub 2010 Oct 18. Erratum in: J Clin Invest. 2012 Jan;122(1):419. Retraction in: J Clin Invest. 2012 Mar;122(3):1131.

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