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Items: 1 to 20 of 112

1.

ROS-mediated autophagy induced by dysregulation of lipid metabolism plays a protective role in colorectal cancer cells treated with gambogic acid.

Zhang H, Lei Y, Yuan P, Li L, Luo C, Gao R, Tian J, Feng Z, Nice EC, Sun J.

PLoS One. 2014 May 8;9(5):e96418. doi: 10.1371/journal.pone.0096418. eCollection 2014.

2.

Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway.

Yang Y, Sun X, Yang Y, Yang X, Zhu H, Dai S, Chen X, Zhang H, Guo Q, Song Y, Wang F, Cheng H, Sun X.

Tumour Biol. 2016 Feb;37(2):1853-62. doi: 10.1007/s13277-015-3974-1. Epub 2015 Aug 30.

PMID:
26318432
3.

Reactive oxygen species accumulation contributes to gambogic acid-induced apoptosis in human hepatoma SMMC-7721 cells.

Nie F, Zhang X, Qi Q, Yang L, Yang Y, Liu W, Lu N, Wu Z, You Q, Guo Q.

Toxicology. 2009 Jun 16;260(1-3):60-7. doi: 10.1016/j.tox.2009.03.010. Epub 2009 Mar 24.

PMID:
19464570
4.

Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression.

Wang S, Wang L, Chen M, Wang Y.

Chem Biol Interact. 2015 Jun 25;235:76-84. doi: 10.1016/j.cbi.2015.03.017. Epub 2015 Mar 27.

PMID:
25824409
5.

Gambogic acid induces apoptosis and inhibits colorectal tumor growth via mitochondrial pathways.

Huang GM, Sun Y, Ge X, Wan X, Li CB.

World J Gastroenterol. 2015 May 28;21(20):6194-205. doi: 10.3748/wjg.v21.i20.6194.

6.

Gambogic acid promotes apoptosis and resistance to metastatic potential in MDA-MB-231 human breast carcinoma cells.

Li C, Qi Q, Lu N, Dai Q, Li F, Wang X, You Q, Guo Q.

Biochem Cell Biol. 2012 Dec;90(6):718-30. doi: 10.1139/o2012-030. Epub 2012 Oct 30.

PMID:
23194187
7.
8.

Gambogic acid induces apoptotic cell death in T98G glioma cells.

Thida M, Kim DW, Tran TTT, Pham MQ, Lee H, Kim I, Lee JW.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):1097-1101. doi: 10.1016/j.bmcl.2015.11.043. Epub 2015 Nov 14.

PMID:
26631318
9.

Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.

Liang L, Zhang Z.

Cell Physiol Biochem. 2016;38(4):1618-30. doi: 10.1159/000443102. Epub 2016 Apr 28.

10.

Gambogic acid synergistically potentiates cisplatin-induced apoptosis in non-small-cell lung cancer through suppressing NF-κB and MAPK/HO-1 signalling.

Wang LH, Li Y, Yang SN, Wang FY, Hou Y, Cui W, Chen K, Cao Q, Wang S, Zhang TY, Wang ZZ, Xiao W, Yang JY, Wu CF.

Br J Cancer. 2014 Jan 21;110(2):341-52. doi: 10.1038/bjc.2013.752. Epub 2013 Dec 3.

11.

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma.

He D, Xu Q, Yan M, Zhang P, Zhou X, Zhang Z, Duan W, Zhong L, Ye D, Chen W.

BMC Cancer. 2009 Sep 25;9:343. doi: 10.1186/1471-2407-9-343.

12.

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Niu NK, Wang ZL, Pan ST, Ding HQ, Au GH, He ZX, Zhou ZW, Xiao G, Yang YX, Zhang X, Yang T, Chen XW, Qiu JX, Zhou SF.

Drug Des Devel Ther. 2015 Mar 12;9:1555-84. doi: 10.2147/DDDT.S74197. eCollection 2015.

13.

Gambogic acid induces death of K562 cells through autophagy and apoptosis mechanisms.

Chen J, Zhou M, Zhang Q, Xu J, Ouyang J.

Leuk Lymphoma. 2015;56(10):2953-8. doi: 10.3109/10428194.2015.1018251. Epub 2015 May 20.

PMID:
25699654
14.

New targets for the antitumor activity of gambogic acid in hematologic malignancies.

Yang LJ, Chen Y.

Acta Pharmacol Sin. 2013 Feb;34(2):191-8. doi: 10.1038/aps.2012.163. Epub 2012 Dec 31. Review.

15.

Calcium channel blocker verapamil accelerates gambogic acid-induced cytotoxicity via enhancing proteasome inhibition and ROS generation.

Liu N, Huang H, Liu S, Li X, Yang C, Dou QP, Liu J.

Toxicol In Vitro. 2014 Apr;28(3):419-25. doi: 10.1016/j.tiv.2013.12.008. Epub 2013 Dec 27.

PMID:
24373880
16.

P38 MAP kinase functions as a switch in MS-275-induced reactive oxygen species-dependent autophagy and apoptosis in human colon cancer cells.

Zhan Y, Gong K, Chen C, Wang H, Li W.

Free Radic Biol Med. 2012 Aug 1;53(3):532-43. doi: 10.1016/j.freeradbiomed.2012.05.018. Epub 2012 May 23.

PMID:
22634147
17.

Juglanin induces apoptosis and autophagy in human breast cancer progression via ROS/JNK promotion.

Sun ZL, Dong JL, Wu J.

Biomed Pharmacother. 2017 Jan;85:303-312. doi: 10.1016/j.biopha.2016.11.030. Epub 2016 Nov 26.

PMID:
27899257
18.

Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines.

Zou Z, Xie L, Wei J, Yu L, Qian X, Chen J, Wang T, Liu B.

BMC Complement Altern Med. 2012 Apr 30;12:58. doi: 10.1186/1472-6882-12-58.

19.

FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.

Zhang L, Wang H, Ding K, Xu J.

Toxicol Lett. 2015 Jul 2;236(1):43-59. doi: 10.1016/j.toxlet.2015.04.015. Epub 2015 May 1.

PMID:
25939952
20.

Inhibition of Autophagy Potentiated the Antitumor Effect of Nedaplatin in Cisplatin-Resistant Nasopharyngeal Carcinoma Cells.

Liu Z, Liu J, Li L, Nie D, Tao Q, Wu J, Fan J, Lin C, Zhao S, Ju D.

PLoS One. 2015 Aug 19;10(8):e0135236. doi: 10.1371/journal.pone.0135236. eCollection 2015.

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